Nomimicins B-D, new tetronate-class polyketides from a marine-derived actinomycete of the genus Actinomadura

Zhiwei Zhang, Tao Zhou, Taehui Yang, Keisuke Fukaya, Enjuro Harunari, Shun Saito, Katsuhisa Yamada, Chiaki Imada, Daisuke Urabe, Yasuhiro Igarashi

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)

Abstract

Three new tetronate-class polyketides, nomimicins B, C, and D, along with nomimicin, hereafter named nomimicin A, were isolated from the culture extract of Actinomadura sp. AKA43 collected from floating particles in the deep-sea water of Sagami Bay, Japan. The structures of nomimicins B, C, and D were elucidated through the interpretation of NMR and MS analytical data, and the absolute configuration was determined by combination of NOESY/ROESY and ECD analyses. Nomimicins B, C, and D showed antimicrobial activity against Gram-positive bacteria, Kocuria rhizophila and Bacillus subtilis, with MIC values in the range of 6.5 to 12.5 μg/mL. Nomimicins B and C also displayed cytotoxicity against P388 murine leukemia cells with IC50 values of 33 and 89 μM, respectively.

Original languageEnglish
Pages (from-to)2194-2202
Number of pages9
JournalBeilstein Journal of Organic Chemistry
Volume17
DOIs
Publication statusPublished - 2021
Externally publishedYes

Keywords

  • Actinomadura
  • Nomimicin
  • Polyketide
  • Spirotetronate

ASJC Scopus subject areas

  • Organic Chemistry

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