Nomogram Prediction of Metachronous Colorectal Neoplasms in Patients with Colorectal Cancer

Kazushige Kawai, Soichiro Ishihara, Hironori Yamaguchi, Eiji Sunami, Joji Kitayama, Hiroaki Miyata, Toshiaki Watanabe

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Objective: To construct a predictive model of postoperative colorectal neoplasm development using a nomogram. Background: Although patients with colorectal cancer (CRC) are known to be at high risk of developing metachronous adenoma or CRC, no statistical model for predicting the incidence of postoperative colorectal lesions has been reported. Methods: A total of 309 CRC patients who underwent surgical resection received regular endoscopic follow-up to detect the development of metachronous adenoma or adenocarcinoma. The patients were divided into the derivation set (n = 209) and the validation set (n = 100). The nomogram to predict the 3-and 5-year adenoma-free survival rates was constructed using the derivation set, and a calibration plot and concordance index (c-index) were calculated. The predictive utility of the nomogram was validated in the validation set. Results: Sex, age, and number of synchronous lesions at the time of surgery for primary CRC were adopted as variables for the nomogram. The nomogram showed moderate calibration, with a c-index of 0.709 in the derivation set and 0.712 in the validation set. Conclusions: A nomogram based on sex, age, and number of synchronous lesions at the time of surgery has the ability to predict postoperative adenoma-free survival.

Original languageEnglish
Pages (from-to)926-932
Number of pages7
JournalAnnals of Surgery
Volume261
Issue number5
DOIs
Publication statusPublished - 2015 May 1
Externally publishedYes

Fingerprint

Nomograms
Second Primary Neoplasms
Colorectal Neoplasms
Adenoma
Calibration
Statistical Models
Adenocarcinoma
Survival Rate
Survival
Incidence

Keywords

  • colonoscopy
  • colorectal adenoma
  • colorectal cancer
  • nomogram
  • postoperative surveillance

ASJC Scopus subject areas

  • Surgery
  • Medicine(all)

Cite this

Kawai, K., Ishihara, S., Yamaguchi, H., Sunami, E., Kitayama, J., Miyata, H., & Watanabe, T. (2015). Nomogram Prediction of Metachronous Colorectal Neoplasms in Patients with Colorectal Cancer. Annals of Surgery, 261(5), 926-932. https://doi.org/10.1097/SLA.0000000000000881

Nomogram Prediction of Metachronous Colorectal Neoplasms in Patients with Colorectal Cancer. / Kawai, Kazushige; Ishihara, Soichiro; Yamaguchi, Hironori; Sunami, Eiji; Kitayama, Joji; Miyata, Hiroaki; Watanabe, Toshiaki.

In: Annals of Surgery, Vol. 261, No. 5, 01.05.2015, p. 926-932.

Research output: Contribution to journalArticle

Kawai, K, Ishihara, S, Yamaguchi, H, Sunami, E, Kitayama, J, Miyata, H & Watanabe, T 2015, 'Nomogram Prediction of Metachronous Colorectal Neoplasms in Patients with Colorectal Cancer', Annals of Surgery, vol. 261, no. 5, pp. 926-932. https://doi.org/10.1097/SLA.0000000000000881
Kawai, Kazushige ; Ishihara, Soichiro ; Yamaguchi, Hironori ; Sunami, Eiji ; Kitayama, Joji ; Miyata, Hiroaki ; Watanabe, Toshiaki. / Nomogram Prediction of Metachronous Colorectal Neoplasms in Patients with Colorectal Cancer. In: Annals of Surgery. 2015 ; Vol. 261, No. 5. pp. 926-932.
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