Non-invasive computed fractional flow reserve from computed tomography (Ct) for diagnosing coronary artery disease; japanese results from nxt trial (analysis of coronary blood flow using ct angiography: Next steps)

Toru Miyoshi, Kazuhiro Osawa, Hiroshi Ito, Susumu Kanazawa, Takeshi Kimura, Hiroki Shiomi, Sachio Kuribayashi, Masahiro Jinzaki, Akio Kawamura, Hiram Bezerra, Hiram Bezerra, Bjarne L. Nørgaard

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Background: Recently, a non-invasive method using computational fluid dynamics to calculate vessel-specific fractional flow reserve (FFRct) from routinely acquired coronary computed tomography angiography (CTA) was described. The Analysis of Coronary Blood Flow Using CT Angiography: Next Steps (NXT) trial, which was a prospective, multicenter trial including 254 patients with suspected coronary artery disease, noted high diagnostic performance of FFRct compared with invasive FFR. The aim of this post-hoc analysis was to assess the diagnostic performance of non-invasive FFRct vs. standard stenosis quantification on coronary CTA in the Japanese subset of the NXT trial.

Conclusions: FFRct has high diagnostic performance compared with invasive FFR in the Japanese subset of patients in the NXT trial.

Methods and Results: A total of 57 Japanese participants were included from Okayama University (n=36), Kyoto University (n=17), and Keio University (n=4) Hospitals. Per-patient diagnostic accuracy of FFRct (74%; 95% confidence interval [CI]: 60–85%) was higher than for coronary CTA (47%; 95% CI: 34–61%, P<0.001) arising from improved specificity (63% vs. 27%, P<0.001). FFRct correctly reclassified 53% of patients and 63% of vessels with coronary CTA false positives as true negatives. When patients with Agatston score >1,000 were excluded, per-pa-tient accuracy of FFRct was 83% with a high specificity of 76%, similar to the overall NXT trial findings.

Original languageEnglish
Pages (from-to)406-412
Number of pages7
JournalCirculation Journal
Volume79
Issue number2
DOIs
Publication statusPublished - 2015 Jan 16

Keywords

  • Computed tomography
  • Coronary artery disease
  • Fractional flow reserve

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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