Non-myeloablative stem cell transplant using 2-chlorodeoxyadenosine (2- CdA) in a patient with myelodysplastic syndrome (MDS)

T. Saito, S. Seo, Ryuji Tanosaki, Y. Takaue, S. Mineishi

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Non-myeloablative conditioning regimens for allogeneic stem cell transplant have become popular recently. With non-myeloablative conditioning, regimen-related toxicities (RRT) are mild and engraftment of allogeneic graft can be achieved consistently. We performed non-myeloablative allogeneic peripheral blood stem cell transplant using 2-chlorodeoxyadenosine (Cladribine; 2-CdA), busulfan, and anti-thymocyte globulin (ATG) for a patient with myelodysplastic syndrome (MDS). He also had hemochromatosis in the liver due to blood transfusions. His post-transplant clinical course was uncomplicated. Non-myeloablative conditioning regimen containing 2-CdA facilitates engraftment with minimal toxicity.

Original languageEnglish
Pages (from-to)88-90
Number of pages3
JournalExperimental Oncology
Volume22
Issue number1-2
Publication statusPublished - 2000
Externally publishedYes

Fingerprint

Cladribine
Myelodysplastic Syndromes
Stem Cells
Transplants
Busulfan
Antilymphocyte Serum
Hemochromatosis
Blood Transfusion
Liver

Keywords

  • Cladribine
  • Myelodysplastic syndrome
  • Non-myeloablative stem cell transplant
  • Organ dysfunction

ASJC Scopus subject areas

  • Cancer Research

Cite this

Non-myeloablative stem cell transplant using 2-chlorodeoxyadenosine (2- CdA) in a patient with myelodysplastic syndrome (MDS). / Saito, T.; Seo, S.; Tanosaki, Ryuji; Takaue, Y.; Mineishi, S.

In: Experimental Oncology, Vol. 22, No. 1-2, 2000, p. 88-90.

Research output: Contribution to journalArticle

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