Non-pharmacological management for patients with frontotemporal dementia

A systematic review

Shunichiro Shinagawa, Shinichiro Nakajima, Eric Plitman, Ariel Graff-Guerrero, Masaru Mimura, Kazuhiko Nakayama, Bruce L. Miller

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Frontotemporal dementia (FTD) is a neurodegenerative disorder characterized by changes in behavior and language caused by focal degeneration of the frontal and anterior temporal lobes. The behavioral symptoms are distressing to patients and their caregivers. Non-pharmacological management is important as no disease-specific pharmacological treatment for FTD is currently available. The primary objective is to review the literature on non-pharmacological management for FTD and to propose directions for future research, with reference to findings. A search was performed using PubMed, MEDLINE, and EMBASE. Search terms included 'frontotemporal dementia', and words related to non-pharmacological management, and it identified a total of 858 articles. Results revealed that very few randomized controlled trials exist on non-pharmacological management interventions for FTD. These interventions have been proposed by literature based on clinical experience. A small number of studies have supported behavioral management techniques that exploit disease-specific behaviors and preserved functions in patients with FTD, along with the management of caregivers' distress. These limitations warrant well-designed large-scale research to examine effects of non-pharmacological interventions on behavioral symptoms of FTD.

Original languageEnglish
Pages (from-to)283-293
Number of pages11
JournalJournal of Alzheimer's Disease
Volume45
Issue number1
DOIs
Publication statusPublished - 2015

Fingerprint

Frontotemporal Dementia
Behavioral Symptoms
Caregivers
Temporal Lobe
PubMed
MEDLINE
Neurodegenerative Diseases
Language
Randomized Controlled Trials
Pharmacology
Research

Keywords

  • Behavioral management
  • caregiver support
  • environmental strategies
  • non-pharmacological interventions in frontotemporal dementia

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Geriatrics and Gerontology
  • Clinical Psychology

Cite this

Non-pharmacological management for patients with frontotemporal dementia : A systematic review. / Shinagawa, Shunichiro; Nakajima, Shinichiro; Plitman, Eric; Graff-Guerrero, Ariel; Mimura, Masaru; Nakayama, Kazuhiko; Miller, Bruce L.

In: Journal of Alzheimer's Disease, Vol. 45, No. 1, 2015, p. 283-293.

Research output: Contribution to journalArticle

Shinagawa, Shunichiro ; Nakajima, Shinichiro ; Plitman, Eric ; Graff-Guerrero, Ariel ; Mimura, Masaru ; Nakayama, Kazuhiko ; Miller, Bruce L. / Non-pharmacological management for patients with frontotemporal dementia : A systematic review. In: Journal of Alzheimer's Disease. 2015 ; Vol. 45, No. 1. pp. 283-293.
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