Non-sentinel lymph node status and prognosis of breast cancer patients with micrometastatic sentinel lymph nodes

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9 Citations (Scopus)

Abstract

Background: The prognostic significance of sentinel lymph node (SLN) micrometastases and the need for axillary lymph node dissection (ALND) on patients with micrometastases in SLNs remain controversial. Methods: A prospective database of 657 breast cancer patients who underwent SLN biopsy (SLNB) was analyzed. SLNs were detected using a combined method of isosulfan blue dye and small-sized technetium-99m-labeled tin colloid. Results: Micrometastases in SLNs were found in 50 (7.6%) of 657 patients. Twenty-nine (58.0%) of 50 patients with micrometastatic SLNs underwent ALND and no further metastases were found in non-sentinel lymph nodes. Among 21 patients (42.0%) with micrometastatic SLNs who decided to forego ALND, no axillary lymph node recurrence has been observed during a median follow-up time of 47 months. There is no significant difference in recurrence-free survival between the patients with micrometastatic and negative SLNs (p = 0.90). Conclusions: These data suggest that it may not be necessary to perform ALND on patients with micrometastases in SLNs and that the presence of micrometastases in SLNs may not be associated with prognosis.

Original languageEnglish
Pages (from-to)344-349
Number of pages6
JournalEuropean Surgical Research
Volume45
Issue number3-4
DOIs
Publication statusPublished - 2010 Dec

Fingerprint

Neoplasm Micrometastasis
Lymph Nodes
Breast Neoplasms
Lymph Node Excision
Recurrence
Sentinel Lymph Node Biopsy
Tin
Technetium
Colloids
Sentinel Lymph Node
Coloring Agents
Databases
Neoplasm Metastasis
Survival

Keywords

  • Micrometastasis
  • Prognosis
  • Sentinel lymph node

ASJC Scopus subject areas

  • Surgery

Cite this

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title = "Non-sentinel lymph node status and prognosis of breast cancer patients with micrometastatic sentinel lymph nodes",
abstract = "Background: The prognostic significance of sentinel lymph node (SLN) micrometastases and the need for axillary lymph node dissection (ALND) on patients with micrometastases in SLNs remain controversial. Methods: A prospective database of 657 breast cancer patients who underwent SLN biopsy (SLNB) was analyzed. SLNs were detected using a combined method of isosulfan blue dye and small-sized technetium-99m-labeled tin colloid. Results: Micrometastases in SLNs were found in 50 (7.6{\%}) of 657 patients. Twenty-nine (58.0{\%}) of 50 patients with micrometastatic SLNs underwent ALND and no further metastases were found in non-sentinel lymph nodes. Among 21 patients (42.0{\%}) with micrometastatic SLNs who decided to forego ALND, no axillary lymph node recurrence has been observed during a median follow-up time of 47 months. There is no significant difference in recurrence-free survival between the patients with micrometastatic and negative SLNs (p = 0.90). Conclusions: These data suggest that it may not be necessary to perform ALND on patients with micrometastases in SLNs and that the presence of micrometastases in SLNs may not be associated with prognosis.",
keywords = "Micrometastasis, Prognosis, Sentinel lymph node",
author = "T. Onishi and H. Jinno and Maiko Takahashi and Tetsu Hayashida and M. Sakata and Tadaki Nakahara and Naoyuki Shigematsu and M. Mukai and Yuukou Kitagawa",
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TY - JOUR

T1 - Non-sentinel lymph node status and prognosis of breast cancer patients with micrometastatic sentinel lymph nodes

AU - Onishi, T.

AU - Jinno, H.

AU - Takahashi, Maiko

AU - Hayashida, Tetsu

AU - Sakata, M.

AU - Nakahara, Tadaki

AU - Shigematsu, Naoyuki

AU - Mukai, M.

AU - Kitagawa, Yuukou

PY - 2010/12

Y1 - 2010/12

N2 - Background: The prognostic significance of sentinel lymph node (SLN) micrometastases and the need for axillary lymph node dissection (ALND) on patients with micrometastases in SLNs remain controversial. Methods: A prospective database of 657 breast cancer patients who underwent SLN biopsy (SLNB) was analyzed. SLNs were detected using a combined method of isosulfan blue dye and small-sized technetium-99m-labeled tin colloid. Results: Micrometastases in SLNs were found in 50 (7.6%) of 657 patients. Twenty-nine (58.0%) of 50 patients with micrometastatic SLNs underwent ALND and no further metastases were found in non-sentinel lymph nodes. Among 21 patients (42.0%) with micrometastatic SLNs who decided to forego ALND, no axillary lymph node recurrence has been observed during a median follow-up time of 47 months. There is no significant difference in recurrence-free survival between the patients with micrometastatic and negative SLNs (p = 0.90). Conclusions: These data suggest that it may not be necessary to perform ALND on patients with micrometastases in SLNs and that the presence of micrometastases in SLNs may not be associated with prognosis.

AB - Background: The prognostic significance of sentinel lymph node (SLN) micrometastases and the need for axillary lymph node dissection (ALND) on patients with micrometastases in SLNs remain controversial. Methods: A prospective database of 657 breast cancer patients who underwent SLN biopsy (SLNB) was analyzed. SLNs were detected using a combined method of isosulfan blue dye and small-sized technetium-99m-labeled tin colloid. Results: Micrometastases in SLNs were found in 50 (7.6%) of 657 patients. Twenty-nine (58.0%) of 50 patients with micrometastatic SLNs underwent ALND and no further metastases were found in non-sentinel lymph nodes. Among 21 patients (42.0%) with micrometastatic SLNs who decided to forego ALND, no axillary lymph node recurrence has been observed during a median follow-up time of 47 months. There is no significant difference in recurrence-free survival between the patients with micrometastatic and negative SLNs (p = 0.90). Conclusions: These data suggest that it may not be necessary to perform ALND on patients with micrometastases in SLNs and that the presence of micrometastases in SLNs may not be associated with prognosis.

KW - Micrometastasis

KW - Prognosis

KW - Sentinel lymph node

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