Non-thermal myocardial electrical conduction block by photosensitization reaction with catheterization in right atrium isthmus of porcine heart in vivo

Arisa Ito, Takuro Kajihara, Tsukasa Suenari, Mei Takahashi, Takehiro Kimura, Kotaro Fukumoto, Seiji Takatsuki, Shunichiro Miyoshi, Tsunenori Arai

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

We have studied a new type of myocardial catheter ablation with photosensitization reaction to realize non-thermal therapy for atrial arrhythmia, such as atrial fibrillation. Photochemically-generated reactive oxygen species may induce myocardial electrophysiological damage without heat generation. In this study, to demonstrate photosensitization reaction-induced myocardial electrical conduction block, the inferior vena cava to tricuspid annulus (IVC-TA) isthmus linear ablation was conducted with photosensitization reaction in porcine heart in vivo, using a newly developed laser catheter (7 Fr.). The end point of the procedure was the production of IVC-TA isthmus block under the electrophysiological analysis by diagnostic catheter with 10-bipole electrodes placed in right atrium along the isthmus. Talaporfin sodium (NPe6) as a photosensitizer was injected intravenously to pigs at 2.5-5.0 mg/kg. About 15 min after the injection, the laser light at the wavelength of 663 nm with a catheter output power density of 40-60 W/cm2 in about 1.4 mm spot size was irradiated through the laser catheter point by point in line crossing the isthmus under the fluoroscopic guidance. Before the photosensitization procedure, pacing signal from the distal electrodes of the diagnostic catheter, propagated through the isthmus in order. During the irradiation, electrical potential at the irradiated area was diminished. After the completion of the irradiation line, the bidirectional conduction block on the IVC-TA isthmus was validated by pacing from the distal and proximal bipole. These results indicated that photosensitization reaction could achieve the electrical conduction block of myocardial tissue immediately after the irradiation. We think that photosensitization reaction could become a novel therapy for atrial arrhythmia.

Original languageEnglish
Title of host publicationProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume7883
DOIs
Publication statusPublished - 2011
EventPhotonic Therapeutics and Diagnostics VII - San Francisco, CA, United States
Duration: 2011 Jan 222011 Jan 24

Other

OtherPhotonic Therapeutics and Diagnostics VII
CountryUnited States
CitySan Francisco, CA
Period11/1/2211/1/24

Fingerprint

isthmuses
catheterization
Photosensitivity Disorders
Catheters
Heart Atria
Catheterization
Swine
conduction
annuli
Inferior Vena Cava
arrhythmia
Lasers
Irradiation
Ablation
ablation
irradiation
Cardiac Arrhythmias
therapy
Electrodes
fibrillation

Keywords

  • atrial Arrhythmia
  • cardiac ablation
  • electrical conduction block
  • myocardial tissue
  • photodynamic therapy
  • photosensitization reaction
  • talaporfin sodium

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics
  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Radiology Nuclear Medicine and imaging

Cite this

Ito, A., Kajihara, T., Suenari, T., Takahashi, M., Kimura, T., Fukumoto, K., ... Arai, T. (2011). Non-thermal myocardial electrical conduction block by photosensitization reaction with catheterization in right atrium isthmus of porcine heart in vivo. In Progress in Biomedical Optics and Imaging - Proceedings of SPIE (Vol. 7883). [78833K] https://doi.org/10.1117/12.872621

Non-thermal myocardial electrical conduction block by photosensitization reaction with catheterization in right atrium isthmus of porcine heart in vivo. / Ito, Arisa; Kajihara, Takuro; Suenari, Tsukasa; Takahashi, Mei; Kimura, Takehiro; Fukumoto, Kotaro; Takatsuki, Seiji; Miyoshi, Shunichiro; Arai, Tsunenori.

Progress in Biomedical Optics and Imaging - Proceedings of SPIE. Vol. 7883 2011. 78833K.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Ito, A, Kajihara, T, Suenari, T, Takahashi, M, Kimura, T, Fukumoto, K, Takatsuki, S, Miyoshi, S & Arai, T 2011, Non-thermal myocardial electrical conduction block by photosensitization reaction with catheterization in right atrium isthmus of porcine heart in vivo. in Progress in Biomedical Optics and Imaging - Proceedings of SPIE. vol. 7883, 78833K, Photonic Therapeutics and Diagnostics VII, San Francisco, CA, United States, 11/1/22. https://doi.org/10.1117/12.872621
Ito A, Kajihara T, Suenari T, Takahashi M, Kimura T, Fukumoto K et al. Non-thermal myocardial electrical conduction block by photosensitization reaction with catheterization in right atrium isthmus of porcine heart in vivo. In Progress in Biomedical Optics and Imaging - Proceedings of SPIE. Vol. 7883. 2011. 78833K https://doi.org/10.1117/12.872621
Ito, Arisa ; Kajihara, Takuro ; Suenari, Tsukasa ; Takahashi, Mei ; Kimura, Takehiro ; Fukumoto, Kotaro ; Takatsuki, Seiji ; Miyoshi, Shunichiro ; Arai, Tsunenori. / Non-thermal myocardial electrical conduction block by photosensitization reaction with catheterization in right atrium isthmus of porcine heart in vivo. Progress in Biomedical Optics and Imaging - Proceedings of SPIE. Vol. 7883 2011.
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