Nonactic Acid Derivatives Isolated from Streptomyces werraensis IFM12104 in a Screening Program for BMI1 Promoter Inhibitory Activity

Yusuke Yokoyama, Midori A. Arai, Yasumasa Hara, Masami Ishibashi

Research output: Contribution to journalArticle

Abstract

Upon screening for compounds with B cell-specific Moloney murine leukemia virus region 1 (BMI1) promoter inhibitory activity, 3 nonactic acid derivatives (1-3) were isolated from Streptomyces werraensis IFM12104. Although spectral data of compound 1 were identical with those reported in literature for 4α-(3, 5-dihydroxy-heptyl)-3α-methyl-2-oxetanone (4), compound 1 was revealed to be homononactic acid by X-ray analysis. Compounds 2 and 3 were identified as bishomononactic acid and nonactic acid using spectral data. The 3 compounds 1 to 3 inhibited BMI1 promoter activities with IC50 values of 240, 160, and 180 μM, respectively.

Original languageEnglish
JournalNatural product communications
Volume14
Issue number7
DOIs
Publication statusPublished - 2019 Jan 1
Externally publishedYes

Keywords

  • Actinomycetes
  • BMI1
  • Nonactic acid
  • Screening
  • Streptomyces

ASJC Scopus subject areas

  • Pharmacology
  • Plant Science
  • Drug Discovery
  • Complementary and alternative medicine

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