Nonactic Acid Derivatives Isolated from Streptomyces werraensis IFM12104 in a Screening Program for BMI1 Promoter Inhibitory Activity

Yusuke Yokoyama; Midori A. Arai; Yasumasa Hara; Masami Ishibashi

doi:10.1177/1934578X19866583

Nonactic Acid Derivatives Isolated from Streptomyces werraensis IFM12104 in a Screening Program for BMI1 Promoter Inhibitory Activity

Yusuke Yokoyama, Midori A. Arai, Yasumasa Hara, Masami Ishibashi

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Abstract

Upon screening for compounds with B cell-specific Moloney murine leukemia virus region 1 (BMI1) promoter inhibitory activity, 3 nonactic acid derivatives (1-3) were isolated from Streptomyces werraensis IFM12104. Although spectral data of compound 1 were identical with those reported in literature for 4α-(3, 5-dihydroxy-heptyl)-3α-methyl-2-oxetanone (4), compound 1 was revealed to be homononactic acid by X-ray analysis. Compounds 2 and 3 were identified as bishomononactic acid and nonactic acid using spectral data. The 3 compounds 1 to 3 inhibited BMI1 promoter activities with IC₅₀ values of 240, 160, and 180 μM, respectively.

Original language	English
Journal	Natural product communications
Volume	14
Issue number	7
DOIs	https://doi.org/10.1177/1934578X19866583
Publication status	Published - 2019
Externally published	Yes

Keywords

Actinomycetes
BMI1
Nonactic acid
Screening
Streptomyces

ASJC Scopus subject areas

Pharmacology
Plant Science
Drug Discovery
Complementary and alternative medicine

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10.1177/1934578X19866583

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title = "Nonactic Acid Derivatives Isolated from Streptomyces werraensis IFM12104 in a Screening Program for BMI1 Promoter Inhibitory Activity",

abstract = "Upon screening for compounds with B cell-specific Moloney murine leukemia virus region 1 (BMI1) promoter inhibitory activity, 3 nonactic acid derivatives (1-3) were isolated from Streptomyces werraensis IFM12104. Although spectral data of compound 1 were identical with those reported in literature for 4α-(3, 5-dihydroxy-heptyl)-3α-methyl-2-oxetanone (4), compound 1 was revealed to be homononactic acid by X-ray analysis. Compounds 2 and 3 were identified as bishomononactic acid and nonactic acid using spectral data. The 3 compounds 1 to 3 inhibited BMI1 promoter activities with IC50 values of 240, 160, and 180 μM, respectively.",

keywords = "Actinomycetes, BMI1, Nonactic acid, Screening, Streptomyces",

author = "Yusuke Yokoyama and Arai, {Midori A.} and Yasumasa Hara and Masami Ishibashi",

note = "Funding Information: The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This work was supported by KAKENHI grant nos. 17H03992 and 19H04640 from the Japan Society for the Promotion of Science. Publisher Copyright: {\textcopyright} The Author(s) 2019",

year = "2019",

doi = "10.1177/1934578X19866583",

language = "English",

volume = "14",

journal = "Natural Product Communications",

issn = "1934-578X",

publisher = "Natural Product Communications",

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T1 - Nonactic Acid Derivatives Isolated from Streptomyces werraensis IFM12104 in a Screening Program for BMI1 Promoter Inhibitory Activity

AU - Yokoyama, Yusuke

AU - Arai, Midori A.

AU - Hara, Yasumasa

AU - Ishibashi, Masami

N1 - Funding Information: The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This work was supported by KAKENHI grant nos. 17H03992 and 19H04640 from the Japan Society for the Promotion of Science. Publisher Copyright: © The Author(s) 2019

PY - 2019

Y1 - 2019

N2 - Upon screening for compounds with B cell-specific Moloney murine leukemia virus region 1 (BMI1) promoter inhibitory activity, 3 nonactic acid derivatives (1-3) were isolated from Streptomyces werraensis IFM12104. Although spectral data of compound 1 were identical with those reported in literature for 4α-(3, 5-dihydroxy-heptyl)-3α-methyl-2-oxetanone (4), compound 1 was revealed to be homononactic acid by X-ray analysis. Compounds 2 and 3 were identified as bishomononactic acid and nonactic acid using spectral data. The 3 compounds 1 to 3 inhibited BMI1 promoter activities with IC50 values of 240, 160, and 180 μM, respectively.

AB - Upon screening for compounds with B cell-specific Moloney murine leukemia virus region 1 (BMI1) promoter inhibitory activity, 3 nonactic acid derivatives (1-3) were isolated from Streptomyces werraensis IFM12104. Although spectral data of compound 1 were identical with those reported in literature for 4α-(3, 5-dihydroxy-heptyl)-3α-methyl-2-oxetanone (4), compound 1 was revealed to be homononactic acid by X-ray analysis. Compounds 2 and 3 were identified as bishomononactic acid and nonactic acid using spectral data. The 3 compounds 1 to 3 inhibited BMI1 promoter activities with IC50 values of 240, 160, and 180 μM, respectively.

KW - Actinomycetes

KW - BMI1

KW - Nonactic acid

KW - Screening

KW - Streptomyces

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Nonactic Acid Derivatives Isolated from Streptomyces werraensis IFM12104 in a Screening Program for BMI1 Promoter Inhibitory Activity

Abstract

Keywords

ASJC Scopus subject areas

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