Nonactin and related compounds found in a screening program for wnt signal inhibitory activity

Yuuya Tamai, Kazufumi Toume, Midori A. Arai, Akinori Hayashida, Hikaru Kato, Yoshikazu Shizuri, Sachiko Tsukamoto, Masami Ishibashi

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

A screening study using a luciferase assay to identify natural products with inhibitory activity against Wnt signaling was carried out. Fractionation of the culture extract of an actinomycete, strain CKK179, led to the identification of nonactin (1), monactin (2), and dinactin (3) as active compounds. We examined the effects of dimeric dinactin (4), isolated from another actinomycete, Streptomyces sp. (YM09-028), on Wnt signaling activity and found that 1 - 4 inhibited TCF/β-catenin transcriptional activity with IC50 values of 0.6 - 7.4 nM.

Original languageEnglish
Pages (from-to)1245-1250
Number of pages6
JournalHeterocycles
Volume84
Issue number2
DOIs
Publication statusPublished - 2012 Feb 7
Externally publishedYes

ASJC Scopus subject areas

  • Analytical Chemistry
  • Pharmacology
  • Organic Chemistry

Fingerprint Dive into the research topics of 'Nonactin and related compounds found in a screening program for wnt signal inhibitory activity'. Together they form a unique fingerprint.

  • Cite this

    Tamai, Y., Toume, K., Arai, M. A., Hayashida, A., Kato, H., Shizuri, Y., Tsukamoto, S., & Ishibashi, M. (2012). Nonactin and related compounds found in a screening program for wnt signal inhibitory activity. Heterocycles, 84(2), 1245-1250. https://doi.org/10.3987/COM-11-S(P)18