Abstract
For decades, it has been recognized that proteins, which are encoded by our genomes via transcription and translation, are building blocks that play vital roles in almost all biological processes. Mutations identified in many proteincoding genes are linked to various human diseases. However, this "proteincentered" dogma has been challenged in recent years with the discovery that majority of our genome is "noncoding" yet transcribed. Noncoding RNA has become the focus of "next generation" biology. Here, we review the emerging field of noncoding RNAs, including microRNAs (miRNAs) and long noncoding RNAs (lncRNAs), and their function in cardiovascular biology and disease.
Original language | English |
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Title of host publication | Etiology and Morphogenesis of Congenital Heart Disease |
Subtitle of host publication | From Gene Function and Cellular Interaction to Morphology |
Publisher | Springer Japan |
Pages | 313-317 |
Number of pages | 5 |
ISBN (Electronic) | 9784431546283 |
ISBN (Print) | 9784431546276 |
DOIs | |
Publication status | Published - 2016 Jan 1 |
Externally published | Yes |
Keywords
- Cardiac disease
- Heart development
- Long noncoding RNAs
- MicroRNAs
ASJC Scopus subject areas
- Medicine(all)
- Biochemistry, Genetics and Molecular Biology(all)