Noncoding RNAs in cardiovascular disease

Masaharu Kataoka; Da Zhi Wang

doi:10.1007/978-4-431-54628-3_44

Noncoding RNAs in cardiovascular disease

Masaharu Kataoka, Da Zhi Wang

Research output: Chapter in Book/Report/Conference proceeding › Chapter

5 Citations (Scopus)

Abstract

For decades, it has been recognized that proteins, which are encoded by our genomes via transcription and translation, are building blocks that play vital roles in almost all biological processes. Mutations identified in many proteincoding genes are linked to various human diseases. However, this "proteincentered" dogma has been challenged in recent years with the discovery that majority of our genome is "noncoding" yet transcribed. Noncoding RNA has become the focus of "next generation" biology. Here, we review the emerging field of noncoding RNAs, including microRNAs (miRNAs) and long noncoding RNAs (lncRNAs), and their function in cardiovascular biology and disease.

Original language	English
Title of host publication	Etiology and Morphogenesis of Congenital Heart Disease
Subtitle of host publication	From Gene Function and Cellular Interaction to Morphology
Publisher	Springer Japan
Pages	313-317
Number of pages	5
ISBN (Electronic)	9784431546283
ISBN (Print)	9784431546276
DOIs	https://doi.org/10.1007/978-4-431-54628-3_44
Publication status	Published - 2016 Jan 1
Externally published	Yes

Keywords

Cardiac disease
Heart development
Long noncoding RNAs
MicroRNAs

ASJC Scopus subject areas

Medicine(all)
Biochemistry, Genetics and Molecular Biology(all)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/978-4-431-54628-3_44

Cite this

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AB - For decades, it has been recognized that proteins, which are encoded by our genomes via transcription and translation, are building blocks that play vital roles in almost all biological processes. Mutations identified in many proteincoding genes are linked to various human diseases. However, this "proteincentered" dogma has been challenged in recent years with the discovery that majority of our genome is "noncoding" yet transcribed. Noncoding RNA has become the focus of "next generation" biology. Here, we review the emerging field of noncoding RNAs, including microRNAs (miRNAs) and long noncoding RNAs (lncRNAs), and their function in cardiovascular biology and disease.

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KW - Heart development

KW - Long noncoding RNAs

KW - MicroRNAs

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ER -

Noncoding RNAs in cardiovascular disease

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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