Nonfunctioning Islet Cell Tumors of the Pancreas: Clinical, Imaging and Pathological Aspects in 16 Patients

Hiroyoshi Furukawa, Kiyoshi Mukai, Tomoo Kosuge, Yae Kanai, Kazuaki Shimada, Junji Yamamoto, Yasunori Mizuguchi, Kyosuke Ushio

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

Background: Nonfunctioning islet cell tumors (NFICTs) usually reach a large size prior to detection, at which stage patients have some symptoms or signs. Recently, NFICTs have been discovered in asymptomatic patients with increasing frequency owing to advances in diagnostic imaging techniques. This study investigated clinical, imaging and pathological features in recent cases of NFICT. Methods: The medical records, radiographs and pathological specimens of 16 patients with NFICT who were evaluated between April 1991 and March 1996 were reviewed. Results: Tumor sizes ranged from 0.8 to 17 cm (average, 5.2 cm). Five patients (31%) had some symptoms or signs at the time of diagnosis; however, the other 11 (69%) had no symptoms. Of 10 patients with a tumor of size 5 cm or less, nine were asymptomatic and all tumors were histologically benign. In contrast, in six patients with a tumor larger than 5 cm, four had some symptoms and five tumors were malignant. The detection rates of pancreatic tumor mass on ultrasonography and computed tomography were 94% (15/16) each. All 14 patients in whom the tumor was completely resected survived without recurrence; however, the remaining two patients with liver metastases died following recurrence. Conclusions: US and CT are useful in detecting NFICTs even if the tumor is small and the patient is asymptomatic. The detection of NFICTs of small size and their complete removal are essential for a successful cure.

Original languageEnglish
Pages (from-to)255-261
Number of pages7
JournalJapanese Journal of Clinical Oncology
Volume28
Issue number4
Publication statusPublished - 1998
Externally publishedYes

Fingerprint

Islet Cell Adenoma
Pancreas
Neoplasms
Signs and Symptoms
Recurrence
Diagnostic Imaging
Medical Records
Ultrasonography
Tomography
Neoplasm Metastasis

Keywords

  • Diagnosis
  • Endocrine tumor of the pancreas
  • Pancreatic neoplasm
  • Pathology
  • Prognosis

ASJC Scopus subject areas

  • Oncology

Cite this

Furukawa, H., Mukai, K., Kosuge, T., Kanai, Y., Shimada, K., Yamamoto, J., ... Ushio, K. (1998). Nonfunctioning Islet Cell Tumors of the Pancreas: Clinical, Imaging and Pathological Aspects in 16 Patients. Japanese Journal of Clinical Oncology, 28(4), 255-261.

Nonfunctioning Islet Cell Tumors of the Pancreas : Clinical, Imaging and Pathological Aspects in 16 Patients. / Furukawa, Hiroyoshi; Mukai, Kiyoshi; Kosuge, Tomoo; Kanai, Yae; Shimada, Kazuaki; Yamamoto, Junji; Mizuguchi, Yasunori; Ushio, Kyosuke.

In: Japanese Journal of Clinical Oncology, Vol. 28, No. 4, 1998, p. 255-261.

Research output: Contribution to journalArticle

Furukawa, H, Mukai, K, Kosuge, T, Kanai, Y, Shimada, K, Yamamoto, J, Mizuguchi, Y & Ushio, K 1998, 'Nonfunctioning Islet Cell Tumors of the Pancreas: Clinical, Imaging and Pathological Aspects in 16 Patients', Japanese Journal of Clinical Oncology, vol. 28, no. 4, pp. 255-261.
Furukawa, Hiroyoshi ; Mukai, Kiyoshi ; Kosuge, Tomoo ; Kanai, Yae ; Shimada, Kazuaki ; Yamamoto, Junji ; Mizuguchi, Yasunori ; Ushio, Kyosuke. / Nonfunctioning Islet Cell Tumors of the Pancreas : Clinical, Imaging and Pathological Aspects in 16 Patients. In: Japanese Journal of Clinical Oncology. 1998 ; Vol. 28, No. 4. pp. 255-261.
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