Abstract
Background: Nonfunctioning islet cell tumors (NFICTs) usually reach a large size prior to detection, at which stage patients have some symptoms or signs. Recently, NFICTs have been discovered in asymptomatic patients with increasing frequency owing to advances in diagnostic imaging techniques. This study investigated clinical, imaging and pathological features in recent cases of NFICT. Methods: The medical records, radiographs and pathological specimens of 16 patients with NFICT who were evaluated between April 1991 and March 1996 were reviewed. Results: Tumor sizes ranged from 0.8 to 17 cm (average, 5.2 cm). Five patients (31%) had some symptoms or signs at the time of diagnosis; however, the other 11 (69%) had no symptoms. Of 10 patients with a tumor of size 5 cm or less, nine were asymptomatic and all tumors were histologically benign. In contrast, in six patients with a tumor larger than 5 cm, four had some symptoms and five tumors were malignant. The detection rates of pancreatic tumor mass on ultrasonography and computed tomography were 94% (15/16) each. All 14 patients in whom the tumor was completely resected survived without recurrence; however, the remaining two patients with liver metastases died following recurrence. Conclusions: US and CT are useful in detecting NFICTs even if the tumor is small and the patient is asymptomatic. The detection of NFICTs of small size and their complete removal are essential for a successful cure.
| Original language | English |
|---|---|
| Pages (from-to) | 255-261 |
| Number of pages | 7 |
| Journal | Japanese Journal of Clinical Oncology |
| Volume | 28 |
| Issue number | 4 |
| Publication status | Published - 1998 |
| Externally published | Yes |
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Keywords
- Diagnosis
- Endocrine tumor of the pancreas
- Pancreatic neoplasm
- Pathology
- Prognosis
ASJC Scopus subject areas
- Oncology
Cite this
Nonfunctioning Islet Cell Tumors of the Pancreas : Clinical, Imaging and Pathological Aspects in 16 Patients. / Furukawa, Hiroyoshi; Mukai, Kiyoshi; Kosuge, Tomoo; Kanai, Yae; Shimada, Kazuaki; Yamamoto, Junji; Mizuguchi, Yasunori; Ushio, Kyosuke.
In: Japanese Journal of Clinical Oncology, Vol. 28, No. 4, 1998, p. 255-261.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Nonfunctioning Islet Cell Tumors of the Pancreas
T2 - Clinical, Imaging and Pathological Aspects in 16 Patients
AU - Furukawa, Hiroyoshi
AU - Mukai, Kiyoshi
AU - Kosuge, Tomoo
AU - Kanai, Yae
AU - Shimada, Kazuaki
AU - Yamamoto, Junji
AU - Mizuguchi, Yasunori
AU - Ushio, Kyosuke
PY - 1998
Y1 - 1998
N2 - Background: Nonfunctioning islet cell tumors (NFICTs) usually reach a large size prior to detection, at which stage patients have some symptoms or signs. Recently, NFICTs have been discovered in asymptomatic patients with increasing frequency owing to advances in diagnostic imaging techniques. This study investigated clinical, imaging and pathological features in recent cases of NFICT. Methods: The medical records, radiographs and pathological specimens of 16 patients with NFICT who were evaluated between April 1991 and March 1996 were reviewed. Results: Tumor sizes ranged from 0.8 to 17 cm (average, 5.2 cm). Five patients (31%) had some symptoms or signs at the time of diagnosis; however, the other 11 (69%) had no symptoms. Of 10 patients with a tumor of size 5 cm or less, nine were asymptomatic and all tumors were histologically benign. In contrast, in six patients with a tumor larger than 5 cm, four had some symptoms and five tumors were malignant. The detection rates of pancreatic tumor mass on ultrasonography and computed tomography were 94% (15/16) each. All 14 patients in whom the tumor was completely resected survived without recurrence; however, the remaining two patients with liver metastases died following recurrence. Conclusions: US and CT are useful in detecting NFICTs even if the tumor is small and the patient is asymptomatic. The detection of NFICTs of small size and their complete removal are essential for a successful cure.
AB - Background: Nonfunctioning islet cell tumors (NFICTs) usually reach a large size prior to detection, at which stage patients have some symptoms or signs. Recently, NFICTs have been discovered in asymptomatic patients with increasing frequency owing to advances in diagnostic imaging techniques. This study investigated clinical, imaging and pathological features in recent cases of NFICT. Methods: The medical records, radiographs and pathological specimens of 16 patients with NFICT who were evaluated between April 1991 and March 1996 were reviewed. Results: Tumor sizes ranged from 0.8 to 17 cm (average, 5.2 cm). Five patients (31%) had some symptoms or signs at the time of diagnosis; however, the other 11 (69%) had no symptoms. Of 10 patients with a tumor of size 5 cm or less, nine were asymptomatic and all tumors were histologically benign. In contrast, in six patients with a tumor larger than 5 cm, four had some symptoms and five tumors were malignant. The detection rates of pancreatic tumor mass on ultrasonography and computed tomography were 94% (15/16) each. All 14 patients in whom the tumor was completely resected survived without recurrence; however, the remaining two patients with liver metastases died following recurrence. Conclusions: US and CT are useful in detecting NFICTs even if the tumor is small and the patient is asymptomatic. The detection of NFICTs of small size and their complete removal are essential for a successful cure.
KW - Diagnosis
KW - Endocrine tumor of the pancreas
KW - Pancreatic neoplasm
KW - Pathology
KW - Prognosis
UR - http://www.scopus.com/inward/record.url?scp=0032038272&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0032038272&partnerID=8YFLogxK
M3 - Article
C2 - 9657011
AN - SCOPUS:0032038272
VL - 28
SP - 255
EP - 261
JO - Japanese Journal of Clinical Oncology
JF - Japanese Journal of Clinical Oncology
SN - 0368-2811
IS - 4
ER -