TY - JOUR
T1 - Noninvasive Interference Tear Meniscometry in Dry Eye Patients With Sjögren Syndrome
AU - Uchida, Atsuro
AU - Uchino, Miki
AU - Goto, Eiki
AU - Hosaka, Eri
AU - Kasuya, Yuko
AU - Fukagawa, Kazumi
AU - Dogru, Murat
AU - Ogawa, Yoko
AU - Tsubota, Kazuo
N1 - Funding Information:
This study was supported by Grant no. 18070501 from the Japanese Ministry of Health, Labour, and Welfare, Tokyo, Japan. The authors indicate no financial conflict of interest. Involved in design of study (A.U., M.U., E.G.); conduct of study (E.G., K.F., M.D., Y.O., K.T.); collection and analysis of the data (A.U., M.U., E.G., E.H., Y.K.); and approval of the manuscript (E.G., M.D., Y.O., K.T.). Drs Uchida, Uchino, and Goto contributed equally to this study and therefore should be considered equivalent first authors. This research followed the Tenets of the Declaration of Helsinki and informed consent was obtained from all the subjects after explanation of the nature and possible consequences of the study. Institutional Review Board (IRB) committee approval was obtained at Tsurumi University. This clinical trial was registered to Japan Pharmaceutical Information Center, Tokyo, Japan, JapacCTI-060313.
PY - 2007/8
Y1 - 2007/8
N2 - Purpose: To compare noninvasive tear meniscus height (NI-TMH) using a tear interference device in normal subjects and dry eye patients with Sjögren syndrome (SS), and to investigate the applicability of this new method before and after the punctal occlusion procedure. Design: Prospective case control study. Methods: Tear meniscus was visualized noninvasively using a tear interference device (Tearscope plus, Keeler, Windsor, United Kingdom). Tear interference image was captured with digital video camera (SP-321, JFC Sales Plan Co, Tokyo, Japan) attached to the slit-lamp. Lower lid margin NI-TMH was measured using image analysis software. NI-TMH of 28 eyes from 17 normal subjects and 46 eyes from 27 aqueous tear deficiency (ATD) dry eye patients with SS were compared. The change of NI-TMH three weeks after the successful punctal occlusion was examined in 11 eyes of eight dry eye subjects. Results: Tear meniscus was well visualized with the tear interference device in all cases. Lower lid margin NI-TMH was 0.22 ± 0.065 mm in normal subjects, and 0.13 ± 0.042 mm in SS subjects, respectively (P < .0001). After the punctal occlusion, lower lid margin NI-TMH increased significantly from 0.12 ± 0.026 mm to 0.42 ± 0.21 mm (P = .001). Conclusions: NI-TMH was substantially lower in SS subjects and also significantly improved after punctal occlusion. This method is expected to be helpful in the diagnosis and in the evaluation of the efficacy of punctal occlusion in ATD dry eyes such as SS.
AB - Purpose: To compare noninvasive tear meniscus height (NI-TMH) using a tear interference device in normal subjects and dry eye patients with Sjögren syndrome (SS), and to investigate the applicability of this new method before and after the punctal occlusion procedure. Design: Prospective case control study. Methods: Tear meniscus was visualized noninvasively using a tear interference device (Tearscope plus, Keeler, Windsor, United Kingdom). Tear interference image was captured with digital video camera (SP-321, JFC Sales Plan Co, Tokyo, Japan) attached to the slit-lamp. Lower lid margin NI-TMH was measured using image analysis software. NI-TMH of 28 eyes from 17 normal subjects and 46 eyes from 27 aqueous tear deficiency (ATD) dry eye patients with SS were compared. The change of NI-TMH three weeks after the successful punctal occlusion was examined in 11 eyes of eight dry eye subjects. Results: Tear meniscus was well visualized with the tear interference device in all cases. Lower lid margin NI-TMH was 0.22 ± 0.065 mm in normal subjects, and 0.13 ± 0.042 mm in SS subjects, respectively (P < .0001). After the punctal occlusion, lower lid margin NI-TMH increased significantly from 0.12 ± 0.026 mm to 0.42 ± 0.21 mm (P = .001). Conclusions: NI-TMH was substantially lower in SS subjects and also significantly improved after punctal occlusion. This method is expected to be helpful in the diagnosis and in the evaluation of the efficacy of punctal occlusion in ATD dry eyes such as SS.
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U2 - 10.1016/j.ajo.2007.04.006
DO - 10.1016/j.ajo.2007.04.006
M3 - Article
C2 - 17533107
AN - SCOPUS:34447622127
VL - 144
SP - 232-237.e1
JO - American Journal of Ophthalmology
JF - American Journal of Ophthalmology
SN - 0002-9394
IS - 2
ER -