Nonnatural glycosyl anthraquinones as DNA binding and photocleaving agents

Research output: Chapter in Book/Report/Conference proceedingChapter

3 Citations (Scopus)

Abstract

Several artificial anthraquinone-carbohydrate hybrids were designed and synthesized. A selectednumber of hybrids did bind to DNA via intercalation in a sequence-selective manner, leading to inhibitionof DNA cleavage by DNase I, whereas other hybrids cleaved DNA with base selectivity upon photoirradiation.This hybrid system was found to be very important for both DNA binding and photocleaving.

Original languageEnglish
Title of host publicationAnthracycline Chemistry and Biology I
Subtitle of host publicationBiological Occurence and Biosynthesis, Synthesis and Chemistry
EditorsKarsten Krohn
Pages285-298
Number of pages14
DOIs
Publication statusPublished - 2008 Dec 1

Publication series

NameTopics in Current Chemistry
Volume282
ISSN (Print)0340-1022

Keywords

  • Anthraquinone
  • Carbohydrate
  • DNA
  • Intercalation
  • Photocleavage

ASJC Scopus subject areas

  • Chemistry(all)

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  • Cite this

    Toshima, K. (2008). Nonnatural glycosyl anthraquinones as DNA binding and photocleaving agents. In K. Krohn (Ed.), Anthracycline Chemistry and Biology I: Biological Occurence and Biosynthesis, Synthesis and Chemistry (pp. 285-298). (Topics in Current Chemistry; Vol. 282). https://doi.org/10.1007/128-2007-147