TY - JOUR
T1 - Nonthermal cardiac catheter ablation using photodynamic therapy
AU - Kimura, Takehiro
AU - Takatsuki, Seiji
AU - Miyoshi, Shunichiro
AU - Fukumoto, Kotaro
AU - Takahashi, Mei
AU - Ogawa, Emiyu
AU - Ito, Arisa
AU - Arai, Tsunenori
AU - Ogawa, Satoshi
AU - Fukuda, Keiichi
PY - 2013/10
Y1 - 2013/10
N2 - Background: Radiofrequency ablation has limitations, largely related to creation of lesions by heating. Here, we report the first nonthermal ablation by applying photodynamic therapy (PDT) to cardiac tissues using a custom-made deflectable laser catheter. The present study investigated the feasibility of PDT for cavotricuspid isthmus ablation in a canine model. Methods and Results: We evaluated the pharmacokinetic profiles of 17 canines after administration of a photosensitizer (talaporfin sodium) by various protocols. We succeeded in maintaining the photosensitizer concentration at a level in excess of the clinically effective dose for humans. Using a 4-polar 7-French deflectable laser catheter, we performed PDT-mediated cavotricuspid isthmus ablation in 8 canines. PDT caused oxidative injury only to the irradiated area and successfully produced a persistent electric conduction block. No acute, gross changes such as edematous degeneration, thrombus formation, steam pops, or traumatic injury were observed after irradiation. Hematoxylin and eosin staining of tissues samples also showed well-preserved endothelial layers. Testing of the blood samples taken before and after the procedure revealed no remarkable changes. Lesion size at 2 weeks after the procedure and the temperature data collected during irradiation were compared between the PDT and irrigated radiofrequency ablation procedures. A ventricular crosssection revealed a solid PDT lesion, which was as deep as a radiofrequency lesion. In addition, endocardial, surficial, and intramural temperature monitoring during the PDT irradiation clearly demonstrated the nonthermal nature of the ablation technique. Conclusions: Nonthermal PDT-mediated catheter ablation is a potentially novel treatment for cardiac arrhythmias.
AB - Background: Radiofrequency ablation has limitations, largely related to creation of lesions by heating. Here, we report the first nonthermal ablation by applying photodynamic therapy (PDT) to cardiac tissues using a custom-made deflectable laser catheter. The present study investigated the feasibility of PDT for cavotricuspid isthmus ablation in a canine model. Methods and Results: We evaluated the pharmacokinetic profiles of 17 canines after administration of a photosensitizer (talaporfin sodium) by various protocols. We succeeded in maintaining the photosensitizer concentration at a level in excess of the clinically effective dose for humans. Using a 4-polar 7-French deflectable laser catheter, we performed PDT-mediated cavotricuspid isthmus ablation in 8 canines. PDT caused oxidative injury only to the irradiated area and successfully produced a persistent electric conduction block. No acute, gross changes such as edematous degeneration, thrombus formation, steam pops, or traumatic injury were observed after irradiation. Hematoxylin and eosin staining of tissues samples also showed well-preserved endothelial layers. Testing of the blood samples taken before and after the procedure revealed no remarkable changes. Lesion size at 2 weeks after the procedure and the temperature data collected during irradiation were compared between the PDT and irrigated radiofrequency ablation procedures. A ventricular crosssection revealed a solid PDT lesion, which was as deep as a radiofrequency lesion. In addition, endocardial, surficial, and intramural temperature monitoring during the PDT irradiation clearly demonstrated the nonthermal nature of the ablation technique. Conclusions: Nonthermal PDT-mediated catheter ablation is a potentially novel treatment for cardiac arrhythmias.
KW - Atrial flutter
KW - Catheter ablation
KW - Photochemotherapy
KW - Talaporfin
UR - http://www.scopus.com/inward/record.url?scp=84891500702&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84891500702&partnerID=8YFLogxK
U2 - 10.1161/CIRCEP.113.000810
DO - 10.1161/CIRCEP.113.000810
M3 - Article
C2 - 23995252
AN - SCOPUS:84891500702
VL - 6
SP - 1025
EP - 1031
JO - Circulation: Arrhythmia and Electrophysiology
JF - Circulation: Arrhythmia and Electrophysiology
SN - 1941-3149
IS - 5
ER -