Normal predicted values of CT indices reflect emphysematous alterations in the lung

K. Yamaguchi, Kenzo Soejima, H. Matsubara, T. Oguma, T. Inoue, H. Shimada, Masaaki Mori, K. Suzuki, E. Koda

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

In order to obtain normal values and 95% confidence limits of various CT indices, healthy adult subjects with no history of smoking (n = 36) underwent CT scanning under a variety of conditions. By then applying the normal limits thus obtained to CT images of COPD patients (n=45), we examined the sensitivity for detecting abnormal emphysematous changes in the lung fields. To measure emphysematous alterations, we used the average value of lung CT densities (ROI), the maximally appearing value in a CT histogram (Hist. Peak), the relative area with low CT densities below -910 HU (%LDA) and the total cross-sectional area (Area) in each lung section. Regardless of the section thickness (10 mm or 1 mm), the lung volume level at which the breath was held or the site from which CT images were taken (upper, middle or lower lung field), no significant correlation was observed between the CT indices associated with emphysematous changes and the subjects age. This allowed us to define, independently of the subjects age, normal values and 95% confidence limits for the CT indices. Among the CT indices surveyed, %LDA was found to be the most sensitive indicator for detecting emphysematous abnormalities. In so far as the extent of emphysema may be determined by lung CT density, classical CT images of 10-mm section thickness appear to have a sufficiently high sensitivity for the detection of emphysematous abnormalities, such that high-resolution CT may be unnecessary.

Original languageEnglish
Pages (from-to)1060-1066
Number of pages7
JournalJapanese Journal of Thoracic Diseases
Volume35
Issue number10
Publication statusPublished - 1997

Fingerprint

Reference Values
Lung
Emphysema
Chronic Obstructive Pulmonary Disease
Healthy Volunteers
Smoking

Keywords

  • Computed tomography
  • Emphysematous changes
  • High-resolution CT
  • Normal limits

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

Cite this

Yamaguchi, K., Soejima, K., Matsubara, H., Oguma, T., Inoue, T., Shimada, H., ... Koda, E. (1997). Normal predicted values of CT indices reflect emphysematous alterations in the lung. Japanese Journal of Thoracic Diseases, 35(10), 1060-1066.

Normal predicted values of CT indices reflect emphysematous alterations in the lung. / Yamaguchi, K.; Soejima, Kenzo; Matsubara, H.; Oguma, T.; Inoue, T.; Shimada, H.; Mori, Masaaki; Suzuki, K.; Koda, E.

In: Japanese Journal of Thoracic Diseases, Vol. 35, No. 10, 1997, p. 1060-1066.

Research output: Contribution to journalArticle

Yamaguchi, K, Soejima, K, Matsubara, H, Oguma, T, Inoue, T, Shimada, H, Mori, M, Suzuki, K & Koda, E 1997, 'Normal predicted values of CT indices reflect emphysematous alterations in the lung', Japanese Journal of Thoracic Diseases, vol. 35, no. 10, pp. 1060-1066.
Yamaguchi, K. ; Soejima, Kenzo ; Matsubara, H. ; Oguma, T. ; Inoue, T. ; Shimada, H. ; Mori, Masaaki ; Suzuki, K. ; Koda, E. / Normal predicted values of CT indices reflect emphysematous alterations in the lung. In: Japanese Journal of Thoracic Diseases. 1997 ; Vol. 35, No. 10. pp. 1060-1066.
@article{aa87bf8299a54795bf45c0ea378db833,
title = "Normal predicted values of CT indices reflect emphysematous alterations in the lung",
abstract = "In order to obtain normal values and 95{\%} confidence limits of various CT indices, healthy adult subjects with no history of smoking (n = 36) underwent CT scanning under a variety of conditions. By then applying the normal limits thus obtained to CT images of COPD patients (n=45), we examined the sensitivity for detecting abnormal emphysematous changes in the lung fields. To measure emphysematous alterations, we used the average value of lung CT densities (ROI), the maximally appearing value in a CT histogram (Hist. Peak), the relative area with low CT densities below -910 HU ({\%}LDA) and the total cross-sectional area (Area) in each lung section. Regardless of the section thickness (10 mm or 1 mm), the lung volume level at which the breath was held or the site from which CT images were taken (upper, middle or lower lung field), no significant correlation was observed between the CT indices associated with emphysematous changes and the subjects age. This allowed us to define, independently of the subjects age, normal values and 95{\%} confidence limits for the CT indices. Among the CT indices surveyed, {\%}LDA was found to be the most sensitive indicator for detecting emphysematous abnormalities. In so far as the extent of emphysema may be determined by lung CT density, classical CT images of 10-mm section thickness appear to have a sufficiently high sensitivity for the detection of emphysematous abnormalities, such that high-resolution CT may be unnecessary.",
keywords = "Computed tomography, Emphysematous changes, High-resolution CT, Normal limits",
author = "K. Yamaguchi and Kenzo Soejima and H. Matsubara and T. Oguma and T. Inoue and H. Shimada and Masaaki Mori and K. Suzuki and E. Koda",
year = "1997",
language = "English",
volume = "35",
pages = "1060--1066",
journal = "Respiratory Investigation",
issn = "2212-5345",
publisher = "Elsevier BV",
number = "10",

}

TY - JOUR

T1 - Normal predicted values of CT indices reflect emphysematous alterations in the lung

AU - Yamaguchi, K.

AU - Soejima, Kenzo

AU - Matsubara, H.

AU - Oguma, T.

AU - Inoue, T.

AU - Shimada, H.

AU - Mori, Masaaki

AU - Suzuki, K.

AU - Koda, E.

PY - 1997

Y1 - 1997

N2 - In order to obtain normal values and 95% confidence limits of various CT indices, healthy adult subjects with no history of smoking (n = 36) underwent CT scanning under a variety of conditions. By then applying the normal limits thus obtained to CT images of COPD patients (n=45), we examined the sensitivity for detecting abnormal emphysematous changes in the lung fields. To measure emphysematous alterations, we used the average value of lung CT densities (ROI), the maximally appearing value in a CT histogram (Hist. Peak), the relative area with low CT densities below -910 HU (%LDA) and the total cross-sectional area (Area) in each lung section. Regardless of the section thickness (10 mm or 1 mm), the lung volume level at which the breath was held or the site from which CT images were taken (upper, middle or lower lung field), no significant correlation was observed between the CT indices associated with emphysematous changes and the subjects age. This allowed us to define, independently of the subjects age, normal values and 95% confidence limits for the CT indices. Among the CT indices surveyed, %LDA was found to be the most sensitive indicator for detecting emphysematous abnormalities. In so far as the extent of emphysema may be determined by lung CT density, classical CT images of 10-mm section thickness appear to have a sufficiently high sensitivity for the detection of emphysematous abnormalities, such that high-resolution CT may be unnecessary.

AB - In order to obtain normal values and 95% confidence limits of various CT indices, healthy adult subjects with no history of smoking (n = 36) underwent CT scanning under a variety of conditions. By then applying the normal limits thus obtained to CT images of COPD patients (n=45), we examined the sensitivity for detecting abnormal emphysematous changes in the lung fields. To measure emphysematous alterations, we used the average value of lung CT densities (ROI), the maximally appearing value in a CT histogram (Hist. Peak), the relative area with low CT densities below -910 HU (%LDA) and the total cross-sectional area (Area) in each lung section. Regardless of the section thickness (10 mm or 1 mm), the lung volume level at which the breath was held or the site from which CT images were taken (upper, middle or lower lung field), no significant correlation was observed between the CT indices associated with emphysematous changes and the subjects age. This allowed us to define, independently of the subjects age, normal values and 95% confidence limits for the CT indices. Among the CT indices surveyed, %LDA was found to be the most sensitive indicator for detecting emphysematous abnormalities. In so far as the extent of emphysema may be determined by lung CT density, classical CT images of 10-mm section thickness appear to have a sufficiently high sensitivity for the detection of emphysematous abnormalities, such that high-resolution CT may be unnecessary.

KW - Computed tomography

KW - Emphysematous changes

KW - High-resolution CT

KW - Normal limits

UR - http://www.scopus.com/inward/record.url?scp=0031458845&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0031458845&partnerID=8YFLogxK

M3 - Article

VL - 35

SP - 1060

EP - 1066

JO - Respiratory Investigation

JF - Respiratory Investigation

SN - 2212-5345

IS - 10

ER -