Normalization of phospholipids concentration of the gastric mucosa was observed in patients with peptic ulcer after eradication of Helicobacter pylori

Sadatoshi Ishibashi, Ryuichi Iwakiri, Ryo Shimoda, Hibiki Ootani, Seiji Kawasaki, Jutarou Tadano, Atsushi Kikkawa, Akifumi Ootani, Kayoko Oda, Takehiro Fujise, Toshifumi Yoshida, Seiji Tsunada, Hiroyuki Sakata, Kazuma Fujimoto

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Background. Phospholipids concentration in the gastric mucosa decreased in patients with Helicobacter pylori infection. The aim of this study is to examine the effects of eradication of H. pylori on decreasing the phospholipids concentration in the gastric mucosa in patients with gastric or duodenal ulcer. Materials and Methods. Phospholipids (phosphatidylcholine, phosphatidylethanolamine, and sphingonomyeline) were measured in biopsy specimens from the antrum and corpus using thin-layer chromatography. In H. pylori positive patients with gastric ulcer (n = 26) and duodenal ulcer (n = 13), and H. pylori negative controls (n = 20), the biopsy specimens were obtained before and 3 months after eradication. Eradication was performed using lansoprazole, amoxycillin, and clarithromycin. Results. Compared with the H. pylori negative control group, the concentrations of phosphatidylcholine and phosphatidylethanolamine decreased significantly in the gastric ulcer group in both antrum and corpus mucosa, and in the duodenal ulcer group in antrum mucosa. This decrease returned to the control level after eradication. Conclusions. This study demonstrates that the eradication of H. pylori in patients with peptic ulcer normalized the decrease of phosphatidylcholine and phosphatidylethanolamine in the gastric mucosa.

Original languageEnglish
Pages (from-to)245-249
Number of pages5
JournalHelicobacter
Volume7
Issue number4
DOIs
Publication statusPublished - 2002
Externally publishedYes

Fingerprint

Gastric Mucosa
Peptic Ulcer
Helicobacter pylori
Phospholipids
Stomach Ulcer
Duodenal Ulcer
Phosphatidylcholines
Mucous Membrane
Lansoprazole
Biopsy
Clarithromycin
Amoxicillin
Helicobacter Infections
Thin Layer Chromatography
Control Groups
phosphatidylethanolamine

Keywords

  • Duodenal ulcer
  • Gastric ulcer
  • Lansoprazole
  • Phosphatidylcholine
  • Phosphatidylethanolamine
  • Teprenone

ASJC Scopus subject areas

  • Gastroenterology
  • Microbiology

Cite this

Normalization of phospholipids concentration of the gastric mucosa was observed in patients with peptic ulcer after eradication of Helicobacter pylori. / Ishibashi, Sadatoshi; Iwakiri, Ryuichi; Shimoda, Ryo; Ootani, Hibiki; Kawasaki, Seiji; Tadano, Jutarou; Kikkawa, Atsushi; Ootani, Akifumi; Oda, Kayoko; Fujise, Takehiro; Yoshida, Toshifumi; Tsunada, Seiji; Sakata, Hiroyuki; Fujimoto, Kazuma.

In: Helicobacter, Vol. 7, No. 4, 2002, p. 245-249.

Research output: Contribution to journalArticle

Ishibashi, S, Iwakiri, R, Shimoda, R, Ootani, H, Kawasaki, S, Tadano, J, Kikkawa, A, Ootani, A, Oda, K, Fujise, T, Yoshida, T, Tsunada, S, Sakata, H & Fujimoto, K 2002, 'Normalization of phospholipids concentration of the gastric mucosa was observed in patients with peptic ulcer after eradication of Helicobacter pylori', Helicobacter, vol. 7, no. 4, pp. 245-249. https://doi.org/10.1046/j.1523-5378.2002.00086.x
Ishibashi, Sadatoshi ; Iwakiri, Ryuichi ; Shimoda, Ryo ; Ootani, Hibiki ; Kawasaki, Seiji ; Tadano, Jutarou ; Kikkawa, Atsushi ; Ootani, Akifumi ; Oda, Kayoko ; Fujise, Takehiro ; Yoshida, Toshifumi ; Tsunada, Seiji ; Sakata, Hiroyuki ; Fujimoto, Kazuma. / Normalization of phospholipids concentration of the gastric mucosa was observed in patients with peptic ulcer after eradication of Helicobacter pylori. In: Helicobacter. 2002 ; Vol. 7, No. 4. pp. 245-249.
@article{77bed30682b447d198ca54d2a2a173e9,
title = "Normalization of phospholipids concentration of the gastric mucosa was observed in patients with peptic ulcer after eradication of Helicobacter pylori",
abstract = "Background. Phospholipids concentration in the gastric mucosa decreased in patients with Helicobacter pylori infection. The aim of this study is to examine the effects of eradication of H. pylori on decreasing the phospholipids concentration in the gastric mucosa in patients with gastric or duodenal ulcer. Materials and Methods. Phospholipids (phosphatidylcholine, phosphatidylethanolamine, and sphingonomyeline) were measured in biopsy specimens from the antrum and corpus using thin-layer chromatography. In H. pylori positive patients with gastric ulcer (n = 26) and duodenal ulcer (n = 13), and H. pylori negative controls (n = 20), the biopsy specimens were obtained before and 3 months after eradication. Eradication was performed using lansoprazole, amoxycillin, and clarithromycin. Results. Compared with the H. pylori negative control group, the concentrations of phosphatidylcholine and phosphatidylethanolamine decreased significantly in the gastric ulcer group in both antrum and corpus mucosa, and in the duodenal ulcer group in antrum mucosa. This decrease returned to the control level after eradication. Conclusions. This study demonstrates that the eradication of H. pylori in patients with peptic ulcer normalized the decrease of phosphatidylcholine and phosphatidylethanolamine in the gastric mucosa.",
keywords = "Duodenal ulcer, Gastric ulcer, Lansoprazole, Phosphatidylcholine, Phosphatidylethanolamine, Teprenone",
author = "Sadatoshi Ishibashi and Ryuichi Iwakiri and Ryo Shimoda and Hibiki Ootani and Seiji Kawasaki and Jutarou Tadano and Atsushi Kikkawa and Akifumi Ootani and Kayoko Oda and Takehiro Fujise and Toshifumi Yoshida and Seiji Tsunada and Hiroyuki Sakata and Kazuma Fujimoto",
year = "2002",
doi = "10.1046/j.1523-5378.2002.00086.x",
language = "English",
volume = "7",
pages = "245--249",
journal = "Helicobacter",
issn = "1083-4389",
publisher = "Wiley-Blackwell",
number = "4",

}

TY - JOUR

T1 - Normalization of phospholipids concentration of the gastric mucosa was observed in patients with peptic ulcer after eradication of Helicobacter pylori

AU - Ishibashi, Sadatoshi

AU - Iwakiri, Ryuichi

AU - Shimoda, Ryo

AU - Ootani, Hibiki

AU - Kawasaki, Seiji

AU - Tadano, Jutarou

AU - Kikkawa, Atsushi

AU - Ootani, Akifumi

AU - Oda, Kayoko

AU - Fujise, Takehiro

AU - Yoshida, Toshifumi

AU - Tsunada, Seiji

AU - Sakata, Hiroyuki

AU - Fujimoto, Kazuma

PY - 2002

Y1 - 2002

N2 - Background. Phospholipids concentration in the gastric mucosa decreased in patients with Helicobacter pylori infection. The aim of this study is to examine the effects of eradication of H. pylori on decreasing the phospholipids concentration in the gastric mucosa in patients with gastric or duodenal ulcer. Materials and Methods. Phospholipids (phosphatidylcholine, phosphatidylethanolamine, and sphingonomyeline) were measured in biopsy specimens from the antrum and corpus using thin-layer chromatography. In H. pylori positive patients with gastric ulcer (n = 26) and duodenal ulcer (n = 13), and H. pylori negative controls (n = 20), the biopsy specimens were obtained before and 3 months after eradication. Eradication was performed using lansoprazole, amoxycillin, and clarithromycin. Results. Compared with the H. pylori negative control group, the concentrations of phosphatidylcholine and phosphatidylethanolamine decreased significantly in the gastric ulcer group in both antrum and corpus mucosa, and in the duodenal ulcer group in antrum mucosa. This decrease returned to the control level after eradication. Conclusions. This study demonstrates that the eradication of H. pylori in patients with peptic ulcer normalized the decrease of phosphatidylcholine and phosphatidylethanolamine in the gastric mucosa.

AB - Background. Phospholipids concentration in the gastric mucosa decreased in patients with Helicobacter pylori infection. The aim of this study is to examine the effects of eradication of H. pylori on decreasing the phospholipids concentration in the gastric mucosa in patients with gastric or duodenal ulcer. Materials and Methods. Phospholipids (phosphatidylcholine, phosphatidylethanolamine, and sphingonomyeline) were measured in biopsy specimens from the antrum and corpus using thin-layer chromatography. In H. pylori positive patients with gastric ulcer (n = 26) and duodenal ulcer (n = 13), and H. pylori negative controls (n = 20), the biopsy specimens were obtained before and 3 months after eradication. Eradication was performed using lansoprazole, amoxycillin, and clarithromycin. Results. Compared with the H. pylori negative control group, the concentrations of phosphatidylcholine and phosphatidylethanolamine decreased significantly in the gastric ulcer group in both antrum and corpus mucosa, and in the duodenal ulcer group in antrum mucosa. This decrease returned to the control level after eradication. Conclusions. This study demonstrates that the eradication of H. pylori in patients with peptic ulcer normalized the decrease of phosphatidylcholine and phosphatidylethanolamine in the gastric mucosa.

KW - Duodenal ulcer

KW - Gastric ulcer

KW - Lansoprazole

KW - Phosphatidylcholine

KW - Phosphatidylethanolamine

KW - Teprenone

UR - http://www.scopus.com/inward/record.url?scp=20244385420&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=20244385420&partnerID=8YFLogxK

U2 - 10.1046/j.1523-5378.2002.00086.x

DO - 10.1046/j.1523-5378.2002.00086.x

M3 - Article

C2 - 12165032

AN - SCOPUS:20244385420

VL - 7

SP - 245

EP - 249

JO - Helicobacter

JF - Helicobacter

SN - 1083-4389

IS - 4

ER -