Nosocomial BK Polyomavirus Infection Causing Hemorrhagic Cystitis Among Patients With Hematological Malignancies After Hematopoietic Stem Cell Transplantation

J. Kato, T. Mori, T. Suzuki, M. Ito, T. C. Li, M. Sakurai, Y. Yamane, R. Yamazaki, Y. Koda, T. Toyama, N. Hasegawa, S. Okamoto

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

BK polyomavirus (BKPyV) is recognized as a pathogen that causes diseases such as hemorrhagic cystitis and nephritis after allogeneic hematopoietic stem cell transplantation (HSCT) or renal transplantation. BKPyV-associated disease is thought to occur through reactivation under immunosuppression. However, the possibility of its nosocomial transmission and the clinical significance of such transmission have not been elucidated. During a 6-month period, nine adult patients (median age: 47 years) who had hematological disorders and who were treated with HSCT (n = 7) or chemotherapy (n = 2) in a single hematology department developed hemorrhagic cystitis due to BKPyV infection. The polymerase chain reaction products of BKPyV DNA obtained from each patient were sequenced. Of the nine patients, six had subtype I, 2 had subtype IV, and 1 had subtype II or III. In the alignment of sequences, four and two of the six subtype I strains were completely homologous (100%). These results strongly suggest that BKPyV has the potential to cause nosocomial infection within a medical facility, especially among recipients of HSCT. Further studies are clearly warranted to elucidate the route(s) of BKPyV transmission in order to establish optimal infection control.

Original languageEnglish
Pages (from-to)2428-2433
Number of pages6
JournalAmerican Journal of Transplantation
Volume17
Issue number9
DOIs
Publication statusPublished - 2017 Sep

Keywords

  • clinical research/practice
  • infection and infectious agents
  • infection and infectious agents
  • infectious disease
  • viral: BK/JC/polyoma

ASJC Scopus subject areas

  • Immunology and Allergy
  • Transplantation
  • Pharmacology (medical)

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