Nosocomial infection by human bocavirus and human rhinovirus among paediatric patients with respiratory risks

H. Kobayashi, Masayoshi Shinjo(H), K. Sudo, S. Kato, Miyuki Morozumi, G. Koinuma, Takao Takahashi, Y. Takano, Y. Tamura, Naoki Hasegawa

Research output: Contribution to journalArticle

Abstract

Background: Nosocomial infections by respiratory viruses undetected by rapid tests are not often diagnosed. For paediatric patients with background diseases, nosocomial infection could be fatal. Aim: To determine the relationship between developing symptoms by respiratory viruses undetectable by rapid tests and respiratory risks and to improve the management of infection control. Methods: Two episodes of nosocomial infection by human bocavirus (HBoV) and human rhinovirus (HRV) were retrospectively investigated in a tertiary hospital paediatric ward in Japan. Viruses were identified by polymerase chain reaction to determine infection control management. When viruses of the same species were detected from different patients, the virus homology was investigated. The relationship between respiratory risks and developing symptoms was statistically investigated. Findings: Three and four patients with respiratory risks in the HBoV and HRV outbreaks, respectively, developed respiratory symptoms. The nucleotide sequences of two patients in the HBoV outbreak and all four patients in the HRV outbreak were phylogenetically close. In both outbreaks, the patients with respiratory risks developed significantly more symptoms than those without any risk (P = 0.035 and 0.018, respectively). After the patients with respiratory infection were separated from those with respiratory risks, no additional nosocomial infection occurred. Conclusion: Patients with respiratory risks easily develop respiratory symptoms and acquire severe symptoms of nosocomial infection by those viruses. In a paediatric ward, we should adopt not only standard precautions but also isolation management of the patients with respiratory symptoms, even if they have negative results in rapid tests.

Original languageEnglish
JournalJournal of Hospital Infection
DOIs
Publication statusPublished - 2019 Jan 1

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Human bocavirus
Rhinovirus
Cross Infection
Pediatrics
Viruses
Disease Outbreaks
Infection Control
Patient Isolation
Tertiary Care Centers
Respiratory Tract Infections
Japan

Keywords

  • Human bocavirus
  • Human rhinovirus
  • Infection control
  • Nosocomial infection
  • Polymerase chain reaction
  • Respiratory risks

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases

Cite this

Nosocomial infection by human bocavirus and human rhinovirus among paediatric patients with respiratory risks. / Kobayashi, H.; Shinjo(H), Masayoshi; Sudo, K.; Kato, S.; Morozumi, Miyuki; Koinuma, G.; Takahashi, Takao; Takano, Y.; Tamura, Y.; Hasegawa, Naoki.

In: Journal of Hospital Infection, 01.01.2019.

Research output: Contribution to journalArticle

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AU - Kato, S.

AU - Morozumi, Miyuki

AU - Koinuma, G.

AU - Takahashi, Takao

AU - Takano, Y.

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AU - Hasegawa, Naoki

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AB - Background: Nosocomial infections by respiratory viruses undetected by rapid tests are not often diagnosed. For paediatric patients with background diseases, nosocomial infection could be fatal. Aim: To determine the relationship between developing symptoms by respiratory viruses undetectable by rapid tests and respiratory risks and to improve the management of infection control. Methods: Two episodes of nosocomial infection by human bocavirus (HBoV) and human rhinovirus (HRV) were retrospectively investigated in a tertiary hospital paediatric ward in Japan. Viruses were identified by polymerase chain reaction to determine infection control management. When viruses of the same species were detected from different patients, the virus homology was investigated. The relationship between respiratory risks and developing symptoms was statistically investigated. Findings: Three and four patients with respiratory risks in the HBoV and HRV outbreaks, respectively, developed respiratory symptoms. The nucleotide sequences of two patients in the HBoV outbreak and all four patients in the HRV outbreak were phylogenetically close. In both outbreaks, the patients with respiratory risks developed significantly more symptoms than those without any risk (P = 0.035 and 0.018, respectively). After the patients with respiratory infection were separated from those with respiratory risks, no additional nosocomial infection occurred. Conclusion: Patients with respiratory risks easily develop respiratory symptoms and acquire severe symptoms of nosocomial infection by those viruses. In a paediatric ward, we should adopt not only standard precautions but also isolation management of the patients with respiratory symptoms, even if they have negative results in rapid tests.

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