Notch signaling functions as a binary switch for the determination of glandular and luminal fates of endodermal epithelium during chicken stomach development

Yoshimasa Matsuda, Yoshio Wakamatsu, Jun Kohyama, Hideyuki Okano, Kimiko Fukuda, Sadao Yasugi

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

During development of the chicken proventriculus (glandular stomach), gut endoderm differentiates into glandular and luminal epithelium. We found that Delta1-expressing cells, undifferentiated cells and Notch-activated cells colocalize within the endodermal epithelium during early gland formation. Inhibition of Notch signaling using Numb or dominant-negative form of Su(H) resulted in a luminal differentiation, while forced activation of Notch signaling promoted the specification of immature glandular cells, but prevented the subsequent differentiation and the imagination of the glands. These results suggest that Delta1-mediated Notch signaling among endodermal cells functions as a binary switch for determination of glandular and luminal fates, and regulates patterned differentiation of glands in the chicken proventriculus.

Original languageEnglish
Pages (from-to)2783-2793
Number of pages11
JournalDevelopment
Volume132
Issue number12
DOIs
Publication statusPublished - 2005 Jun

Fingerprint

Chickens
Stomach
Epithelium
Proventriculus
Imagination
Endoderm

Keywords

  • Chicken
  • Delta
  • Gland
  • Notch
  • Proventriculus
  • Stomach
  • Su(H)

ASJC Scopus subject areas

  • Anatomy
  • Cell Biology

Cite this

Notch signaling functions as a binary switch for the determination of glandular and luminal fates of endodermal epithelium during chicken stomach development. / Matsuda, Yoshimasa; Wakamatsu, Yoshio; Kohyama, Jun; Okano, Hideyuki; Fukuda, Kimiko; Yasugi, Sadao.

In: Development, Vol. 132, No. 12, 06.2005, p. 2783-2793.

Research output: Contribution to journalArticle

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