Notch3 gene polymorphism and ischaemic cerebrovascular disease

Daisuke Ito, N. Tanahashi, Mitsuru Murata, H. Sato, I. Saito, K. Watanabe, Y. Fukuuchi

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is a type of hereditary stroke and dementia. More than 90% of patients with CADASIL have mutations in the Notch3 gene. All mutations either create or destroy a cysteine residue in the epidermal growth factor-like repeats. In addition, five polymorphisms, which lead to amino acid substitutions, have been identified within the Notch3 coding sequence. However, whether these polymorphisms affect Notch signalling or are involved in cerebrovascular diseases is unknown. In the present study, we investigated a possible association between a T6746C polymorphism in the Notch3 coding region and the occurrence of symptomatic ischaemic cerebrovascular disease (CVD) was investigated. Two hundred and thirty five patients with CVD, as confirmed by brain CT or MRI, and 315 age and sex matched control subjects were analyzed for genotype frequencies of the T6746C polymorphism in Notch3. The genotype distributions were: patients with CVD, C/C 14.0%, C/T 45.5%, and T/T 40.4%; controls, C/C, 14.3%; C/T, 47.9%; T/T, 37.8%. The Japanese population has a higher C allele frequency of the T6746C polymorphism than European populations. There was no significant difference between the T6746C polymorphism in patients with CVD and controls (X2=0.414, p=0.813). This was confirmed by the results of multiple logistic regression analysis including established risk factors (X2 =4.65, p=0.311). In conclusion, the results indicate that T6746C polymorphism in the intracellular domain of the Notch3 gene is not associated with an increased risk for CVD.

Original languageEnglish
Pages (from-to)382-384
Number of pages3
JournalJournal of Neurology Neurosurgery and Psychiatry
Volume72
Issue number3
DOIs
Publication statusPublished - 2002

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Cerebrovascular Disorders
CADASIL
Genes
Genotype
Mutation
Amino Acid Substitution
Epidermal Growth Factor
Gene Frequency
Population
Cysteine
Dementia
Logistic Models
Stroke
Regression Analysis
Brain

ASJC Scopus subject areas

  • Neuropsychology and Physiological Psychology
  • Neuroscience(all)
  • Psychiatry and Mental health

Cite this

Notch3 gene polymorphism and ischaemic cerebrovascular disease. / Ito, Daisuke; Tanahashi, N.; Murata, Mitsuru; Sato, H.; Saito, I.; Watanabe, K.; Fukuuchi, Y.

In: Journal of Neurology Neurosurgery and Psychiatry, Vol. 72, No. 3, 2002, p. 382-384.

Research output: Contribution to journalArticle

Ito, Daisuke ; Tanahashi, N. ; Murata, Mitsuru ; Sato, H. ; Saito, I. ; Watanabe, K. ; Fukuuchi, Y. / Notch3 gene polymorphism and ischaemic cerebrovascular disease. In: Journal of Neurology Neurosurgery and Psychiatry. 2002 ; Vol. 72, No. 3. pp. 382-384.
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