Novel autoantibodies to a voltage-gated potassium channel KV1.4 in a severe form of myasthenia gravis

Shigeaki Suzuki, Takashi Satoh, Hidekata Yasuoka, Yasuhito Hamaguchi, Kortaro Tanaka, Yutaka Kawakami, Norihiro Suzuki, Masataka Kuwana

Research output: Contribution to journalArticle

58 Citations (Scopus)

Abstract

Sera from patients with myasthenia gravis (MG) were screened for autoantibodies to skeletal muscle-specific antigens by immunoprecipitation assay, using rhabdomyosarcoma and leukemia cell lines. Eleven of 61 MG sera immunoprecipitated a rhabdomyosarcoma-specific 70-kDa protein, which was identified as the voltage-gated K+ channel 1.4 (KV1.4). This antibody specificity was not detected in 30 patients with polymyositis/dermatomyositis, 9 with thymoma alone, or 30 healthy controls. Clinical features associated with anti-KV1.4 antibody included bulbar involvement, myasthenic crisis, thymoma, myocarditis, and QT prolongation on electrocardiogram. These findings suggest that anti-KV1.4 antibody is a novel autoantibody associated with a severe MG subset and thymoma.

Original languageEnglish
Pages (from-to)141-149
Number of pages9
JournalJournal of Neuroimmunology
Volume170
Issue number1-2
DOIs
Publication statusPublished - 2005 Dec 30

Keywords

  • Autoantibodies
  • Immunoprecipitation
  • Myasthenia gravis
  • Voltage-gated potassium channel

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Neurology
  • Clinical Neurology

Fingerprint Dive into the research topics of 'Novel autoantibodies to a voltage-gated potassium channel K<sub>V</sub>1.4 in a severe form of myasthenia gravis'. Together they form a unique fingerprint.

  • Cite this

    Suzuki, S., Satoh, T., Yasuoka, H., Hamaguchi, Y., Tanaka, K., Kawakami, Y., Suzuki, N., & Kuwana, M. (2005). Novel autoantibodies to a voltage-gated potassium channel KV1.4 in a severe form of myasthenia gravis. Journal of Neuroimmunology, 170(1-2), 141-149. https://doi.org/10.1016/j.jneuroim.2005.08.017