TY - JOUR
T1 - Novel autoantibodies to a voltage-gated potassium channel KV1.4 in a severe form of myasthenia gravis
AU - Suzuki, Shigeaki
AU - Satoh, Takashi
AU - Yasuoka, Hidekata
AU - Hamaguchi, Yasuhito
AU - Tanaka, Kortaro
AU - Kawakami, Yutaka
AU - Suzuki, Norihiro
AU - Kuwana, Masataka
N1 - Funding Information:
This work was supported by grants from the Japanese Ministry of Education, Science, Sports and Culture (to S.S., M.K.) and the Japanese Ministry of Health, Labor, and Welfare (to M.K.).
PY - 2005/12/30
Y1 - 2005/12/30
N2 - Sera from patients with myasthenia gravis (MG) were screened for autoantibodies to skeletal muscle-specific antigens by immunoprecipitation assay, using rhabdomyosarcoma and leukemia cell lines. Eleven of 61 MG sera immunoprecipitated a rhabdomyosarcoma-specific 70-kDa protein, which was identified as the voltage-gated K+ channel 1.4 (KV1.4). This antibody specificity was not detected in 30 patients with polymyositis/dermatomyositis, 9 with thymoma alone, or 30 healthy controls. Clinical features associated with anti-KV1.4 antibody included bulbar involvement, myasthenic crisis, thymoma, myocarditis, and QT prolongation on electrocardiogram. These findings suggest that anti-KV1.4 antibody is a novel autoantibody associated with a severe MG subset and thymoma.
AB - Sera from patients with myasthenia gravis (MG) were screened for autoantibodies to skeletal muscle-specific antigens by immunoprecipitation assay, using rhabdomyosarcoma and leukemia cell lines. Eleven of 61 MG sera immunoprecipitated a rhabdomyosarcoma-specific 70-kDa protein, which was identified as the voltage-gated K+ channel 1.4 (KV1.4). This antibody specificity was not detected in 30 patients with polymyositis/dermatomyositis, 9 with thymoma alone, or 30 healthy controls. Clinical features associated with anti-KV1.4 antibody included bulbar involvement, myasthenic crisis, thymoma, myocarditis, and QT prolongation on electrocardiogram. These findings suggest that anti-KV1.4 antibody is a novel autoantibody associated with a severe MG subset and thymoma.
KW - Autoantibodies
KW - Immunoprecipitation
KW - Myasthenia gravis
KW - Voltage-gated potassium channel
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U2 - 10.1016/j.jneuroim.2005.08.017
DO - 10.1016/j.jneuroim.2005.08.017
M3 - Article
C2 - 16182377
AN - SCOPUS:28444436590
SN - 0165-5728
VL - 170
SP - 141
EP - 149
JO - Advances in Neuroimmunology
JF - Advances in Neuroimmunology
IS - 1-2
ER -