Novel autoantibodies to a voltage-gated potassium channel KV1.4 in a severe form of myasthenia gravis

Shigeaki Suzuki, Takashi Satoh, Hidekata Yasuoka, Yasuhito Hamaguchi, Kortaro Tanaka, Yutaka Kawakami, Norihiro Suzuki, Masataka Kuwana

Research output: Contribution to journalArticle

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Abstract

Sera from patients with myasthenia gravis (MG) were screened for autoantibodies to skeletal muscle-specific antigens by immunoprecipitation assay, using rhabdomyosarcoma and leukemia cell lines. Eleven of 61 MG sera immunoprecipitated a rhabdomyosarcoma-specific 70-kDa protein, which was identified as the voltage-gated K+ channel 1.4 (KV1.4). This antibody specificity was not detected in 30 patients with polymyositis/dermatomyositis, 9 with thymoma alone, or 30 healthy controls. Clinical features associated with anti-KV1.4 antibody included bulbar involvement, myasthenic crisis, thymoma, myocarditis, and QT prolongation on electrocardiogram. These findings suggest that anti-KV1.4 antibody is a novel autoantibody associated with a severe MG subset and thymoma.

Original languageEnglish
Pages (from-to)141-149
Number of pages9
JournalJournal of Neuroimmunology
Volume170
Issue number1-2
DOIs
Publication statusPublished - 2005 Dec 30

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Voltage-Gated Potassium Channels
Thymoma
Myasthenia Gravis
Autoantibodies
Rhabdomyosarcoma
Anti-Idiotypic Antibodies
Dermatomyositis
Antibody Specificity
Muscle Weakness
Myocarditis
Serum
Immunoprecipitation
Electrocardiography
Leukemia
Skeletal Muscle
Antigens
Cell Line
Proteins

Keywords

  • Autoantibodies
  • Immunoprecipitation
  • Myasthenia gravis
  • Voltage-gated potassium channel

ASJC Scopus subject areas

  • Immunology
  • Clinical Neurology
  • Immunology and Allergy
  • Neurology

Cite this

Novel autoantibodies to a voltage-gated potassium channel KV1.4 in a severe form of myasthenia gravis. / Suzuki, Shigeaki; Satoh, Takashi; Yasuoka, Hidekata; Hamaguchi, Yasuhito; Tanaka, Kortaro; Kawakami, Yutaka; Suzuki, Norihiro; Kuwana, Masataka.

In: Journal of Neuroimmunology, Vol. 170, No. 1-2, 30.12.2005, p. 141-149.

Research output: Contribution to journalArticle

Suzuki, S, Satoh, T, Yasuoka, H, Hamaguchi, Y, Tanaka, K, Kawakami, Y, Suzuki, N & Kuwana, M 2005, 'Novel autoantibodies to a voltage-gated potassium channel KV1.4 in a severe form of myasthenia gravis', Journal of Neuroimmunology, vol. 170, no. 1-2, pp. 141-149. https://doi.org/10.1016/j.jneuroim.2005.08.017
Suzuki, Shigeaki ; Satoh, Takashi ; Yasuoka, Hidekata ; Hamaguchi, Yasuhito ; Tanaka, Kortaro ; Kawakami, Yutaka ; Suzuki, Norihiro ; Kuwana, Masataka. / Novel autoantibodies to a voltage-gated potassium channel KV1.4 in a severe form of myasthenia gravis. In: Journal of Neuroimmunology. 2005 ; Vol. 170, No. 1-2. pp. 141-149.
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