Novel chlorinated dibenzofurans isolated from the cellular slime mold, Polysphondylium filamentosum, and their biological activities

Haruhisa Kikuchi, Yuzuru Kubohara, Van Hai Nguyen, Yasuhiro Katou, Yoshiteru Oshima

Research output: Contribution to journalArticlepeer-review

15 Citations (Scopus)

Abstract

Cellular slime molds are expected to have the huge potential for producing secondary metabolites including polyketides, and we have studied the diversity of secondary metabolites of cellular slime molds for their potential utilization as new biological resources for natural product chemistry. From the methanol extract of fruiting bodies of Polysphondylium filamentosum, we obtained new chlorinated benzofurans Pf-1 (4) and Pf-2 (5) which display multiple biological activities; these include stalk cell differentiation-inducing activity in the well-studied cellular slime mold, Dictyostelium discoideum, and inhibitory activities on cell proliferation in mammalian cells and gene expression in Drosophila melanogaster.

Original languageEnglish
Pages (from-to)4628-4633
Number of pages6
JournalBioorganic and Medicinal Chemistry
Volume21
Issue number15
DOIs
Publication statusPublished - 2013 Aug 1
Externally publishedYes

Keywords

  • Cellular slime molds
  • Dibenzofuran
  • Dictyostelium discoideum
  • Gene expression
  • Stalk cell differentiation

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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