Novel glycosylation methods and their application to natural products synthesis

Kazunobu Toshima

doi:10.1016/j.carres.2006.03.012

Novel glycosylation methods and their application to natural products synthesis

Kazunobu Toshima

Department of Applied Chemistry

Research output: Contribution to journal › Short survey › peer-review

67 Citations (Scopus)

Abstract

In this short review article, several glycosylation methods that were developed in our laboratories, including stereocontrolled glycosylation using 2,6-anhydro-2,6-dideoxy-2,6-dithio sugars for obtaining 2,6-dideoxy glycosides, C-glycosylation employing unprotected sugars, environmentally benign glycosylation utilizing heterogeneous solid acids and ionic liquids, are recounted. In addition, representative and significant applications of these methods to the synthesis of complex natural products are described.

Original language	English
Pages (from-to)	1282-1297
Number of pages	16
Journal	Carbohydrate Research
Volume	341
Issue number	10
DOIs	https://doi.org/10.1016/j.carres.2006.03.012
Publication status	Published - 2006 Jul 24

Keywords

Carbohydrate
Glycomolecule
Glycoside
Glycosylation
Natural product

ASJC Scopus subject areas

Analytical Chemistry
Biochemistry
Organic Chemistry

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AB - In this short review article, several glycosylation methods that were developed in our laboratories, including stereocontrolled glycosylation using 2,6-anhydro-2,6-dideoxy-2,6-dithio sugars for obtaining 2,6-dideoxy glycosides, C-glycosylation employing unprotected sugars, environmentally benign glycosylation utilizing heterogeneous solid acids and ionic liquids, are recounted. In addition, representative and significant applications of these methods to the synthesis of complex natural products are described.

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KW - Glycomolecule

KW - Glycoside

KW - Glycosylation

KW - Natural product

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