Novel hemagglutinin-binding sulfated oligofucosides and their effect on influenza virus infection

Shuhei Kosono; Akihiro Kasai; Sumika Komaba; Teruhiko Matsubara; Toshinori Sato; Daisuke Takahashi; Kazunobu Toshima

doi:10.1039/c8cc03865a

Novel hemagglutinin-binding sulfated oligofucosides and their effect on influenza virus infection

Shuhei Kosono, Akihiro Kasai, Sumika Komaba, Teruhiko Matsubara, Toshinori Sato, Daisuke Takahashi, Kazunobu Toshima

Research output: Contribution to journal › Article › peer-review

9 Citations (Scopus)

Abstract

Among a series of chemically synthesized fucoidan derivatives (1-9), 5 was found for the first time to bind to influenza virus hemagglutinins (HAs) and inhibit hemagglutination activity. In addition, a designed C₃-symmetric tripodal ligand 10, synthesized with three sulfated oligofucoside moieties of 5, exhibited much greater hemagglutination inhibition activity than 5. A plaque assay using MDCK cells demonstrated that 10 effectively inhibited influenza virus infection.

Original language	English
Pages (from-to)	7467-7470
Number of pages	4
Journal	Chemical Communications
Volume	54
Issue number	54
DOIs	https://doi.org/10.1039/c8cc03865a
Publication status	Published - 2018

ASJC Scopus subject areas

Catalysis
Electronic, Optical and Magnetic Materials
Ceramics and Composites
Chemistry(all)
Surfaces, Coatings and Films
Metals and Alloys
Materials Chemistry

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10.1039/c8cc03865a

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abstract = "Among a series of chemically synthesized fucoidan derivatives (1-9), 5 was found for the first time to bind to influenza virus hemagglutinins (HAs) and inhibit hemagglutination activity. In addition, a designed C3-symmetric tripodal ligand 10, synthesized with three sulfated oligofucoside moieties of 5, exhibited much greater hemagglutination inhibition activity than 5. A plaque assay using MDCK cells demonstrated that 10 effectively inhibited influenza virus infection.",

author = "Shuhei Kosono and Akihiro Kasai and Sumika Komaba and Teruhiko Matsubara and Toshinori Sato and Daisuke Takahashi and Kazunobu Toshima",

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T1 - Novel hemagglutinin-binding sulfated oligofucosides and their effect on influenza virus infection

AU - Kosono, Shuhei

AU - Kasai, Akihiro

AU - Komaba, Sumika

AU - Matsubara, Teruhiko

AU - Sato, Toshinori

AU - Takahashi, Daisuke

AU - Toshima, Kazunobu

N1 - Funding Information: This research was supported in part by the JSPS KAKENHI Grant Number JP16H01161 in the Middle Molecular Strategy and Keio Gijuku Academic Development Funds. Publisher Copyright: © 2018 The Royal Society of Chemistry.

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Y1 - 2018

N2 - Among a series of chemically synthesized fucoidan derivatives (1-9), 5 was found for the first time to bind to influenza virus hemagglutinins (HAs) and inhibit hemagglutination activity. In addition, a designed C3-symmetric tripodal ligand 10, synthesized with three sulfated oligofucoside moieties of 5, exhibited much greater hemagglutination inhibition activity than 5. A plaque assay using MDCK cells demonstrated that 10 effectively inhibited influenza virus infection.

AB - Among a series of chemically synthesized fucoidan derivatives (1-9), 5 was found for the first time to bind to influenza virus hemagglutinins (HAs) and inhibit hemagglutination activity. In addition, a designed C3-symmetric tripodal ligand 10, synthesized with three sulfated oligofucoside moieties of 5, exhibited much greater hemagglutination inhibition activity than 5. A plaque assay using MDCK cells demonstrated that 10 effectively inhibited influenza virus infection.

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Novel hemagglutinin-binding sulfated oligofucosides and their effect on influenza virus infection

Abstract

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