Novel hemagglutinin-binding sulfated oligofucosides and their effect on influenza virus infection

Shuhei Kosono, Akihiro Kasai, Sumika Komaba, Teruhiko Matsubara, Toshinori Sato, Daisuke Takahashi, Kazunobu Toshima

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Among a series of chemically synthesized fucoidan derivatives (1-9), 5 was found for the first time to bind to influenza virus hemagglutinins (HAs) and inhibit hemagglutination activity. In addition, a designed C3-symmetric tripodal ligand 10, synthesized with three sulfated oligofucoside moieties of 5, exhibited much greater hemagglutination inhibition activity than 5. A plaque assay using MDCK cells demonstrated that 10 effectively inhibited influenza virus infection.

Original languageEnglish
Pages (from-to)7467-7470
Number of pages4
JournalChemical Communications
Volume54
Issue number54
DOIs
Publication statusPublished - 2018 Jan 1

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Hemagglutinins
Viruses
Assays
Ligands
Derivatives
fucoidan

ASJC Scopus subject areas

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Chemistry(all)
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry

Cite this

Novel hemagglutinin-binding sulfated oligofucosides and their effect on influenza virus infection. / Kosono, Shuhei; Kasai, Akihiro; Komaba, Sumika; Matsubara, Teruhiko; Sato, Toshinori; Takahashi, Daisuke; Toshima, Kazunobu.

In: Chemical Communications, Vol. 54, No. 54, 01.01.2018, p. 7467-7470.

Research output: Contribution to journalArticle

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