Novel heterocyclic enediynes. Molecular design, chemical synthesis and DNA cleavage

Kazunobu Toshima, Kiyoshi Ohishi, Miho Tomishima, Shuichi Matsumura

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

The novel 10-membered oxaenediyne (4a) and azaenediynes (5a∼d) were designed and synthesized in a short procedure, and the azaenediynes (5a∼d) were found to effectively cleave DNA under both weakly acidic and basic conditions with no additive.

Original languageEnglish
Pages (from-to)851-855
Number of pages5
JournalHeterocycles
Volume45
Issue number5
DOIs
Publication statusPublished - 1997 Jan 1

ASJC Scopus subject areas

  • Analytical Chemistry
  • Pharmacology
  • Organic Chemistry

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