Novel heterocyclic enediynes. Molecular design, chemical synthesis and DNA cleavage

Kazunobu Toshima, Kiyoshi Ohishi, Miho Tomishima, Shuichi Matsumura

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

The novel 10-membered oxaenediyne (4a) and azaenediynes (5a∼d) were designed and synthesized in a short procedure, and the azaenediynes (5a∼d) were found to effectively cleave DNA under both weakly acidic and basic conditions with no additive.

Original languageEnglish
Pages (from-to)851-855
Number of pages5
JournalHeterocycles
Volume45
Issue number5
Publication statusPublished - 1997

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Enediynes
DNA Cleavage
DNA

ASJC Scopus subject areas

  • Organic Chemistry

Cite this

Toshima, K., Ohishi, K., Tomishima, M., & Matsumura, S. (1997). Novel heterocyclic enediynes. Molecular design, chemical synthesis and DNA cleavage. Heterocycles, 45(5), 851-855.

Novel heterocyclic enediynes. Molecular design, chemical synthesis and DNA cleavage. / Toshima, Kazunobu; Ohishi, Kiyoshi; Tomishima, Miho; Matsumura, Shuichi.

In: Heterocycles, Vol. 45, No. 5, 1997, p. 851-855.

Research output: Contribution to journalArticle

Toshima, K, Ohishi, K, Tomishima, M & Matsumura, S 1997, 'Novel heterocyclic enediynes. Molecular design, chemical synthesis and DNA cleavage', Heterocycles, vol. 45, no. 5, pp. 851-855.
Toshima, Kazunobu ; Ohishi, Kiyoshi ; Tomishima, Miho ; Matsumura, Shuichi. / Novel heterocyclic enediynes. Molecular design, chemical synthesis and DNA cleavage. In: Heterocycles. 1997 ; Vol. 45, No. 5. pp. 851-855.
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