Novel heterocyclic enediynes. Molecular design, chemical synthesis and DNA cleavage

Kazunobu Toshima; Kiyoshi Ohishi; Miho Tomishima; Shuichi Matsumura

doi:10.3987/COM-97-7777

Novel heterocyclic enediynes. Molecular design, chemical synthesis and DNA cleavage

Kazunobu Toshima, Kiyoshi Ohishi, Miho Tomishima, Shuichi Matsumura

Department of Applied Chemistry

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Abstract

The novel 10-membered oxaenediyne (4a) and azaenediynes (5a∼d) were designed and synthesized in a short procedure, and the azaenediynes (5a∼d) were found to effectively cleave DNA under both weakly acidic and basic conditions with no additive.

Original language	English
Pages (from-to)	851-855
Number of pages	5
Journal	Heterocycles
Volume	45
Issue number	5
DOIs	https://doi.org/10.3987/COM-97-7777
Publication status	Published - 1997 Jan 1

ASJC Scopus subject areas

Analytical Chemistry
Pharmacology
Organic Chemistry

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abstract = "The novel 10-membered oxaenediyne (4a) and azaenediynes (5a∼d) were designed and synthesized in a short procedure, and the azaenediynes (5a∼d) were found to effectively cleave DNA under both weakly acidic and basic conditions with no additive.",

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AU - Ohishi, Kiyoshi

AU - Tomishima, Miho

AU - Matsumura, Shuichi

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AB - The novel 10-membered oxaenediyne (4a) and azaenediynes (5a∼d) were designed and synthesized in a short procedure, and the azaenediynes (5a∼d) were found to effectively cleave DNA under both weakly acidic and basic conditions with no additive.

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Novel heterocyclic enediynes. Molecular design, chemical synthesis and DNA cleavage

Abstract

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