Novel lipase-catalyzed ring-opening copolymerization of lactide and trimethylene carbonate forming poly(ester carbonate)s

Shuichi Matsumura, Keisuke Tsukada, Kazunobu Toshima

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Abstract

Poly(lactide-co-trimethylene carbonate)s were prepared by the lipase- catalyzed ring-opening copolymerization of lactide and trimethylene carbonate having carbonate content from 0 to 100%. Their thermal properties and enzymatic degradability were measured. The L,L-, D,D- and D,L-lactides were copolymerized with trimethylene carbonate by porcine pancreatic lipase to produce random copolymers having molecular weights of up to 21 000. The glass transition temperature (T(g)) of the copolymer was dependent on the carbonate content and the T(g) values linearly decreased from 35°C (polylactide) to - 8°C [poly(trimethylene carbonate)]. Among the lipases tested, the porcine pancreatic lipase and proteinase K showed biodegradability towards poly(ester-carbonate)s.

Original languageEnglish
Pages (from-to)161-167
Number of pages7
JournalInternational Journal of Biological Macromolecules
Volume25
Issue number1-3
DOIs
Publication statusPublished - 1999 Jun

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Keywords

  • Enzymatic copolymerization
  • Poly(ester-carbonate)
  • Polylactide

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology

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