Novel metabolic pathway of estrone and 17β-estradiol catalyzed by cytochrome P-450

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Abstract

We have already reported that the quinol formation from some para- alkylphenols, which is a novel metabolic pathway catalyzed by cytochrome P- 450, occurs in a rat liver microsomal system (Ohe et al., 1997). In the present study, we investigated whether estrone and 17β-estadiol, each of which contains a p-alkylphenol moiety, are also oxidized into the corresponding quinols by cytochrome P-450. Six recombinant human cytochrome P-450 enzymes, CYP1A1, CYP1A2, CYP2B6, CYP2C9, CYP2E1, and CYP3A4, were tested. The results show that estrone and 17β-estadiol were converted into the corresponding quinols by CYP1A1, CYP2B6, and CYP2E1.

Original languageEnglish
Pages (from-to)110-112
Number of pages3
JournalDrug Metabolism and Disposition
Volume28
Issue number2
Publication statusPublished - 2000 Feb 9

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ASJC Scopus subject areas

  • Pharmacology
  • Pharmaceutical Science

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