Novel method of tetramic acid synthesis

Silver-catalyzed carbon dioxide incorporation into propargylic amine and intramolecular rearrangement

Tomonobu Ishida, Ryo Kobayashi, Tohru Yamada

Research output: Contribution to journalArticle

46 Citations (Scopus)

Abstract

Tetramic acid derivatives have been studied as biologically active heterocycle structures for pharmaceutical or agricultural chemicals. Conventional preparative approaches often require highly functionalized starting materials and harsh heating conditions in basic media. The present report provides a conceptually new synthetic strategy for the synthesis of tetramic acid derivatives from easily available propargylic amines and carbon dioxide with a silver salt and DBU under mild reaction conditions.

Original languageEnglish
Pages (from-to)2430-2433
Number of pages4
JournalOrganic Letters
Volume16
Issue number9
DOIs
Publication statusPublished - 2014 May 2

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Silver
Carbon Dioxide
Amines
carbon dioxide
amines
silver
Agrochemicals
Derivatives
acids
synthesis
dioxides
Heating
Salts
salts
heating
Pharmaceutical Preparations
tetramic acid

ASJC Scopus subject areas

  • Organic Chemistry
  • Physical and Theoretical Chemistry
  • Biochemistry

Cite this

Novel method of tetramic acid synthesis : Silver-catalyzed carbon dioxide incorporation into propargylic amine and intramolecular rearrangement. / Ishida, Tomonobu; Kobayashi, Ryo; Yamada, Tohru.

In: Organic Letters, Vol. 16, No. 9, 02.05.2014, p. 2430-2433.

Research output: Contribution to journalArticle

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