Novel oxidative pathway of para-substituted phenols in cytochrome P450 chemical model: Substituent elimination accompanying ipso-substitution by the oxygen atom of the active species1

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Abstract

The meso-telrakis(2,6-difluorophenyl)porpriinatoiron(III) chloride-mCPBA system, a chemical model of cytochrome P450, catalyzed substituent elimination from various para-substituted phenols. An experiment using [18O)mCPBA proved that these reactions are accompanied with ipso- substitution by the oxygen atom of the active species of the P450 model.

Original languageEnglish
Pages (from-to)7681-7684
Number of pages4
JournalTetrahedron Letters
Volume36
Issue number42
DOIs
Publication statusPublished - 1995 Oct 16
Externally publishedYes

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ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry
  • Drug Discovery

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