Novel oxidative pathway of para-substituted phenols in cytochrome P450 chemical model: Substituent elimination accompanying ipso-substitution by the oxygen atom of the active species1

Tomoyuki Ohe; Tadahiko Mashino; Masaaki Hirobe

doi:10.1016/0040-4039(95)01611-K

Novel oxidative pathway of para-substituted phenols in cytochrome P450 chemical model: Substituent elimination accompanying ipso-substitution by the oxygen atom of the active species¹

Tomoyuki Ohe, Tadahiko Mashino, Masaaki Hirobe

Research output: Contribution to journal › Article › peer-review

31 Citations (Scopus)

Abstract

The meso-telrakis(2,6-difluorophenyl)porpriinatoiron(III) chloride-mCPBA system, a chemical model of cytochrome P450, catalyzed substituent elimination from various para-substituted phenols. An experiment using [¹⁸O)mCPBA proved that these reactions are accompanied with ipso- substitution by the oxygen atom of the active species of the P450 model.

Original language	English
Pages (from-to)	7681-7684
Number of pages	4
Journal	Tetrahedron Letters
Volume	36
Issue number	42
DOIs	https://doi.org/10.1016/0040-4039(95)01611-K
Publication status	Published - 1995 Oct 16
Externally published	Yes

ASJC Scopus subject areas

Biochemistry
Drug Discovery
Organic Chemistry

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10.1016/0040-4039(95)01611-K

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Novel oxidative pathway of para-substituted phenols in cytochrome P450 chemical model : Substituent elimination accompanying ipso-substitution by the oxygen atom of the active species¹. / Ohe, Tomoyuki; Mashino, Tadahiko; Hirobe, Masaaki.

In: Tetrahedron Letters, Vol. 36, No. 42, 16.10.1995, p. 7681-7684.

Research output: Contribution to journal › Article › peer-review

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abstract = "The meso-telrakis(2,6-difluorophenyl)porpriinatoiron(III) chloride-mCPBA system, a chemical model of cytochrome P450, catalyzed substituent elimination from various para-substituted phenols. An experiment using [18O)mCPBA proved that these reactions are accompanied with ipso- substitution by the oxygen atom of the active species of the P450 model.",

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AU - Hirobe, Masaaki

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Novel oxidative pathway of para-substituted phenols in cytochrome P450 chemical model: Substituent elimination accompanying ipso-substitution by the oxygen atom of the active species¹

Abstract

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