Novel prenylated and geranylated aromatic compounds isolated from Polysphondylium cellular slime molds

Haruhisa Kikuchi, Shinya Ishiko, Koji Nakamura, Yuzuru Kubohara, Yoshiteru Oshima

Research output: Contribution to journalArticlepeer-review

17 Citations (Scopus)

Abstract

We have studied the diversity of secondary metabolites of cellular slime molds to utilize them as new biological resources for natural product chemistry. From the methanol extract of fruiting bodies of Polysphondylium tenuissimum, we obtained five prenylated and geranylated aromatic compounds, Pt-1-5 (1-5). An additional aromatic compound, Ppc-1 (6), was isolated from Polysphondylium pseudo-candidum. The structures of these compounds were determined by spectral analysis, and synthetic routes to 4, 5, and 6 were developed. Compound 5 showed the glucose consumption-promotive activity on 3T3-L1 cells.

Original languageEnglish
Pages (from-to)6000-6007
Number of pages8
JournalTetrahedron
Volume66
Issue number32
DOIs
Publication statusPublished - 2010 Aug 7
Externally publishedYes

Keywords

  • Cellular slime molds
  • Geranylated aromatic compounds
  • Glucose consumption
  • Polysphondylium tenuissimum
  • Prenylated aromatic compounds

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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