Novel short-duration heating balloon dilatation with uniform temperature distribution

The heating conditions to suppress neo-intimal hyperplasia

M. Kunio, N. Shimazaki, Tsunenori Arai, M. Sakurada

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

We investigate the relation between the influences on smooth muscle cells and the chronic performances of our novel short-duration heating balloon dilatation to reveal the heating conditions which can suppress the neo-intimal hyperplasia after our heating dilatations. The temperature of prototype balloon catheter surface was measured during short-duration heating balloon dilatation ex vivo. There existed 2C temperature variations in the long direction of prototype balloon catheter at a maximum. The neo-intimal hyperplasia occupancy rate after our short-duration heating dilatations were measured in vivo porcine study. The neo-intimal hyperplasia was suppressed most at 75C in balloon peak temperature in vivo. The estimated dead rate of smooth muscle cells at this condition was about 13% by the Arrhenius equation. We think that the suppression of neo-intimal hyperplasia was obtained after our short-duration heating dilatation due to the proper decrease of smooth muscle cells by heating and no thermal damages to the adventitia and surrounding tissues.

Original languageEnglish
Title of host publicationProceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS
Pages349-352
Number of pages4
DOIs
Publication statusPublished - 2011
Event33rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS 2011 - Boston, MA, United States
Duration: 2011 Aug 302011 Sep 3

Other

Other33rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS 2011
CountryUnited States
CityBoston, MA
Period11/8/3011/9/3

Fingerprint

Tunica Intima
Balloons
Heating
Hyperplasia
Dilatation
Temperature distribution
Temperature
Smooth Muscle Myocytes
Muscle
Catheters
Cells
Adventitia
Swine
Hot Temperature
Tissue

ASJC Scopus subject areas

  • Computer Vision and Pattern Recognition
  • Signal Processing
  • Biomedical Engineering
  • Health Informatics

Cite this

Kunio, M., Shimazaki, N., Arai, T., & Sakurada, M. (2011). Novel short-duration heating balloon dilatation with uniform temperature distribution: The heating conditions to suppress neo-intimal hyperplasia. In Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS (pp. 349-352). [6090115] https://doi.org/10.1109/IEMBS.2011.6090115

Novel short-duration heating balloon dilatation with uniform temperature distribution : The heating conditions to suppress neo-intimal hyperplasia. / Kunio, M.; Shimazaki, N.; Arai, Tsunenori; Sakurada, M.

Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS. 2011. p. 349-352 6090115.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Kunio, M, Shimazaki, N, Arai, T & Sakurada, M 2011, Novel short-duration heating balloon dilatation with uniform temperature distribution: The heating conditions to suppress neo-intimal hyperplasia. in Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS., 6090115, pp. 349-352, 33rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS 2011, Boston, MA, United States, 11/8/30. https://doi.org/10.1109/IEMBS.2011.6090115
Kunio M, Shimazaki N, Arai T, Sakurada M. Novel short-duration heating balloon dilatation with uniform temperature distribution: The heating conditions to suppress neo-intimal hyperplasia. In Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS. 2011. p. 349-352. 6090115 https://doi.org/10.1109/IEMBS.2011.6090115
Kunio, M. ; Shimazaki, N. ; Arai, Tsunenori ; Sakurada, M. / Novel short-duration heating balloon dilatation with uniform temperature distribution : The heating conditions to suppress neo-intimal hyperplasia. Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS. 2011. pp. 349-352
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