Novel trichothecanes, paecilomycine A, B, and C, isolated from entomopathogenic fungus, Paecilomyces tenuipes

Haruhisa Kikuchi; Yasuhiro Miyagawa; Yuko Sahashi; Satoshi Inatomi; Asami Haganuma; Norimichi Nakahata; Yoshiteru Oshima

doi:10.1016/j.tetlet.2004.06.107

Novel trichothecanes, paecilomycine A, B, and C, isolated from entomopathogenic fungus, Paecilomyces tenuipes

Haruhisa Kikuchi, Yasuhiro Miyagawa, Yuko Sahashi, Satoshi Inatomi, Asami Haganuma, Norimichi Nakahata, Yoshiteru Oshima

Research output: Contribution to journal › Article › peer-review

13 Citations (Scopus)

Abstract

Paecilomycine A (1), B (2), and C (3) were isolated from cultivated fruiting bodies of Paecilomyces tenuipes (Isaria japonica), which is a popular entomopathogenic fungus used in folk medicine and health foods in China, Korea, and Japan. The structures of 1â€"3 were deduced from their spectroscopic data and their absolute configurations were elucidated by preparing their MPA esters. Compound 1 showed activity in the neurotrophic factor biosynthesis in glial cells.

Original language	English
Pages (from-to)	6225-6228
Number of pages	4
Journal	Tetrahedron Letters
Volume	45
Issue number	33
DOIs	https://doi.org/10.1016/j.tetlet.2004.06.107
Publication status	Published - 2004 Aug 9
Externally published	Yes

Keywords

Glial cell
PC-12 cell
Paecilomyces tenuipes
Trichothecane

ASJC Scopus subject areas

Biochemistry
Drug Discovery
Organic Chemistry

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10.1016/j.tetlet.2004.06.107

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@article{9d3a6b8a7bed40a89485a929e6701b06,

title = "Novel trichothecanes, paecilomycine A, B, and C, isolated from entomopathogenic fungus, Paecilomyces tenuipes",

abstract = "Paecilomycine A (1), B (2), and C (3) were isolated from cultivated fruiting bodies of Paecilomyces tenuipes (Isaria japonica), which is a popular entomopathogenic fungus used in folk medicine and health foods in China, Korea, and Japan. The structures of 1{\^a}€{"}3 were deduced from their spectroscopic data and their absolute configurations were elucidated by preparing their MPA esters. Compound 1 showed activity in the neurotrophic factor biosynthesis in glial cells.",

keywords = "Glial cell, PC-12 cell, Paecilomyces tenuipes, Trichothecane",

author = "Haruhisa Kikuchi and Yasuhiro Miyagawa and Yuko Sahashi and Satoshi Inatomi and Asami Haganuma and Norimichi Nakahata and Yoshiteru Oshima",

note = "Funding Information: This work was supported in part by Grant-in-Aid for Scientific Research (No 13024208) from the Ministry of Education, Science, Sports and Culture of Japan, Shorai Foundation for Science and Technology, Hokuto Foundation for Biological Science, and Takeda Science Foundation.",

year = "2004",

month = aug,

day = "9",

doi = "10.1016/j.tetlet.2004.06.107",

language = "English",

volume = "45",

pages = "6225--6228",

journal = "Tetrahedron Letters",

issn = "0040-4039",

publisher = "Elsevier Limited",

number = "33",

}

TY - JOUR

T1 - Novel trichothecanes, paecilomycine A, B, and C, isolated from entomopathogenic fungus, Paecilomyces tenuipes

AU - Kikuchi, Haruhisa

AU - Miyagawa, Yasuhiro

AU - Sahashi, Yuko

AU - Inatomi, Satoshi

AU - Haganuma, Asami

AU - Nakahata, Norimichi

AU - Oshima, Yoshiteru

N1 - Funding Information: This work was supported in part by Grant-in-Aid for Scientific Research (No 13024208) from the Ministry of Education, Science, Sports and Culture of Japan, Shorai Foundation for Science and Technology, Hokuto Foundation for Biological Science, and Takeda Science Foundation.

PY - 2004/8/9

Y1 - 2004/8/9

N2 - Paecilomycine A (1), B (2), and C (3) were isolated from cultivated fruiting bodies of Paecilomyces tenuipes (Isaria japonica), which is a popular entomopathogenic fungus used in folk medicine and health foods in China, Korea, and Japan. The structures of 1â€"3 were deduced from their spectroscopic data and their absolute configurations were elucidated by preparing their MPA esters. Compound 1 showed activity in the neurotrophic factor biosynthesis in glial cells.

AB - Paecilomycine A (1), B (2), and C (3) were isolated from cultivated fruiting bodies of Paecilomyces tenuipes (Isaria japonica), which is a popular entomopathogenic fungus used in folk medicine and health foods in China, Korea, and Japan. The structures of 1â€"3 were deduced from their spectroscopic data and their absolute configurations were elucidated by preparing their MPA esters. Compound 1 showed activity in the neurotrophic factor biosynthesis in glial cells.

KW - Glial cell

KW - PC-12 cell

KW - Paecilomyces tenuipes

KW - Trichothecane

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DO - 10.1016/j.tetlet.2004.06.107

M3 - Article

AN - SCOPUS:3242795745

SN - 0040-4039

VL - 45

SP - 6225

EP - 6228

JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 33

ER -

Novel trichothecanes, paecilomycine A, B, and C, isolated from entomopathogenic fungus, Paecilomyces tenuipes

Abstract

Keywords

ASJC Scopus subject areas

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