Novel tubular–glomerular interplay in diabetic kidney disease mediated by sirtuin 1, nicotinamide mononucleotide, and nicotinamide adenine dinucleotide Oshima Award Address 2017

Kazuhiro Hasegawa

Research output: Contribution to journalReview article

3 Citations (Scopus)

Abstract

Tubules interact with glomeruli, which are composed of podocytes, parietal epithelial cells, mesangial cells, and glomerular endothelial cells. Glomerular–tubular balance and tubuloglomerular feedback are the two components of the tubular–glomerular interplay, which has been demonstrated to play roles in physiological renal function and in diabetic kidney disease (DKD), in which proteins leaking from glomeruli arrive at tubular regions, leading to further tubular injury caused by the accumulation of proteinuria-inducing reactive oxygens species and various cytokines. In the current review, we present our recent work identifying a novel tubular–glomerular interplay in DKD mediated by sirtuin 1 and nicotinamide mononucleotide.

Original languageEnglish
JournalClinical and experimental nephrology
DOIs
Publication statusPublished - 2019 Jan 1

Keywords

  • Diabetic kidney disease
  • Nicotinamide mononucleotide
  • Sirtuin 1
  • Tubuloglomerular feedback

ASJC Scopus subject areas

  • Physiology
  • Nephrology
  • Physiology (medical)

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