Nuclear receptor mediated gene regulation through chromatin remodeling and histone modifications

Masahiko Kishimoto, Ryoji Fujiki, Shinichiro Takezawa, Yasumasa Sasaki, Takashi Nakamura, Kazuyoshi Yamaoka, Hirochika Kitagawa, Shigeaki Kato

Research output: Contribution to journalReview article

61 Citations (Scopus)

Abstract

Nuclear steroid/thyroid vitamin A/D receptor genes form a gene superfamily and encode DNA-binding transcription factors that control the transcription of target genes in a ligand-dependent manner. It has become clear that chromatin remodeling and the modification of histones, the main components of chromatin, play crucial roles in gene transcription, and many distinct classes of NR-interacting co-regulators have been identified that perform significant roles in gene transcription. Since NR dysfunction can lead to the onset or progression of endocrine disease, elucidation of the mechanisms of gene regulation mediated by NRs, as well as the identification and characterization of co-regulator complexes (especially chromatin remodeling and histone-modifying complexes), is essential not only for better understanding of NR ligand function, but also for pathophysiological studies and the development of therapeutic interventions in humans.

Original languageEnglish
Pages (from-to)157-172
Number of pages16
JournalEndocrine Journal
Volume53
Issue number2
DOIs
Publication statusPublished - 2006
Externally publishedYes

ASJC Scopus subject areas

  • Endocrinology

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  • Cite this

    Kishimoto, M., Fujiki, R., Takezawa, S., Sasaki, Y., Nakamura, T., Yamaoka, K., Kitagawa, H., & Kato, S. (2006). Nuclear receptor mediated gene regulation through chromatin remodeling and histone modifications. Endocrine Journal, 53(2), 157-172. https://doi.org/10.1507/endocrj.53.157