Numerical simulation of near-field fluorescence correlation spectroscopy using a fiber probe

Kazuo Kasahara, Toshiharu Saiki

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1 Citation (Scopus)

Abstract

Numerical simulation of fluorescence correlation spectroscopy (FCS) based on near-field scanning optical microscopy (NSOM) was performed. A finite-difference time-domain method was employed to calculate the electric field distribution in the vicinity of the NSOM aperture and the Brownian motion of nanoparticles was reproduced by a Monte Carlo simulation. The physical validity of the simulation result was confirmed by comparing it with a theoretical calculation using a Gaussian observation volume, which is applied to FCS based on conventional optical microscopy.

Original languageEnglish
Article number043502
JournalJournal of Nanophotonics
Volume4
Issue number1
DOIs
Publication statusPublished - 2010 Feb 15

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Keywords

  • Brownian motion
  • Fluorescence spectroscopy
  • Near-field scanning optical microscopy
  • Optical correlation

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics

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