Obesity, insulin resistance and the implication of thiazolidinediones

Yuko Oguma, K. Kataoka

Research output: Contribution to journalArticle

Abstract

The mechanism of insulin resistance in obesity is not fully understood. In muscle cells, the number of insulin receptor, the function of glucose transporter 4 and the activity of tyrosine kinase decrease. The rink of body fat accumulation and insulin resistance in muscle is thought through free fatty acid and tumor necrosis factor alpha secreted in adipose tissue. Thiazolidinediones (TZDs) are useful to reduce insulin resistance especially in obesity. TZDs seem to cause small weight gain, but to reduce visceral fat in 12-24 weeks. In longer period, it hasn't been studied very much. There are some unsolved problems. So now, targets of TZDs are obese diabetes failed in other medicines. When using TZDs, be cautious of excess eating and physical inactivity.

Original languageEnglish
Pages (from-to)411-415
Number of pages5
JournalNippon rinsho. Japanese journal of clinical medicine
Volume58
Issue number2
Publication statusPublished - 2000

Fingerprint

Thiazolidinediones
Insulin Resistance
Obesity
Adipose Tissue
Intra-Abdominal Fat
Facilitative Glucose Transport Proteins
Lipoma
Insulin Receptor
Nonesterified Fatty Acids
Protein-Tyrosine Kinases
Muscle Cells
Weight Gain
Tumor Necrosis Factor-alpha
Cell Count
Eating
Muscles

Cite this

Obesity, insulin resistance and the implication of thiazolidinediones. / Oguma, Yuko; Kataoka, K.

In: Nippon rinsho. Japanese journal of clinical medicine, Vol. 58, No. 2, 2000, p. 411-415.

Research output: Contribution to journalArticle

@article{e6edccde56f443fea694b16fa665fa63,
title = "Obesity, insulin resistance and the implication of thiazolidinediones",
abstract = "The mechanism of insulin resistance in obesity is not fully understood. In muscle cells, the number of insulin receptor, the function of glucose transporter 4 and the activity of tyrosine kinase decrease. The rink of body fat accumulation and insulin resistance in muscle is thought through free fatty acid and tumor necrosis factor alpha secreted in adipose tissue. Thiazolidinediones (TZDs) are useful to reduce insulin resistance especially in obesity. TZDs seem to cause small weight gain, but to reduce visceral fat in 12-24 weeks. In longer period, it hasn't been studied very much. There are some unsolved problems. So now, targets of TZDs are obese diabetes failed in other medicines. When using TZDs, be cautious of excess eating and physical inactivity.",
author = "Yuko Oguma and K. Kataoka",
year = "2000",
language = "English",
volume = "58",
pages = "411--415",
journal = "Nihon rinsho. Japanese journal of clinical medicine",
issn = "0047-1852",
publisher = "Nipponrinsho Co., Inc.",
number = "2",

}

TY - JOUR

T1 - Obesity, insulin resistance and the implication of thiazolidinediones

AU - Oguma, Yuko

AU - Kataoka, K.

PY - 2000

Y1 - 2000

N2 - The mechanism of insulin resistance in obesity is not fully understood. In muscle cells, the number of insulin receptor, the function of glucose transporter 4 and the activity of tyrosine kinase decrease. The rink of body fat accumulation and insulin resistance in muscle is thought through free fatty acid and tumor necrosis factor alpha secreted in adipose tissue. Thiazolidinediones (TZDs) are useful to reduce insulin resistance especially in obesity. TZDs seem to cause small weight gain, but to reduce visceral fat in 12-24 weeks. In longer period, it hasn't been studied very much. There are some unsolved problems. So now, targets of TZDs are obese diabetes failed in other medicines. When using TZDs, be cautious of excess eating and physical inactivity.

AB - The mechanism of insulin resistance in obesity is not fully understood. In muscle cells, the number of insulin receptor, the function of glucose transporter 4 and the activity of tyrosine kinase decrease. The rink of body fat accumulation and insulin resistance in muscle is thought through free fatty acid and tumor necrosis factor alpha secreted in adipose tissue. Thiazolidinediones (TZDs) are useful to reduce insulin resistance especially in obesity. TZDs seem to cause small weight gain, but to reduce visceral fat in 12-24 weeks. In longer period, it hasn't been studied very much. There are some unsolved problems. So now, targets of TZDs are obese diabetes failed in other medicines. When using TZDs, be cautious of excess eating and physical inactivity.

UR - http://www.scopus.com/inward/record.url?scp=0034133421&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0034133421&partnerID=8YFLogxK

M3 - Article

C2 - 10707567

AN - SCOPUS:0034133421

VL - 58

SP - 411

EP - 415

JO - Nihon rinsho. Japanese journal of clinical medicine

JF - Nihon rinsho. Japanese journal of clinical medicine

SN - 0047-1852

IS - 2

ER -