Abstract
Purpose Obesity contributes to the technical difficulty of rectal surgery and is considered to be a risk factor for postoperative complications. The impact of obesity on the long-term outcomes of rectal cancer surgery remains unclear. Methods A total of 263 consecutive rectal cancer patients who underwent surgery were categorized into two groups according to the body mass index (BMI) based on the Asian BMI classification: non-obese (BMI <25 kg/m2) and obese (BMI ≥25 kg/m2). The postoperative survival and recurrence rates and oncological surgical quality indicators were compared between groups using the univariate and multivariate analyses. The differences in recurrence patterns were assessed by a competing risk regression analysis. Results 64 (24 %) patients were included in the obese group. The number of retrieved lymph nodes was significantly greater in the non-obese group than in the obese group (22.4 vs. 16.0, P < 0.01). The 5-year disease-free survival (DFS) rates were 86.5 and 68.8 % in the obese and non-obese groups, respectively (P = 0.01). The multivariate analysis demonstrated that obesity significantly decreased the postoperative recurrence rate (P = 0.04). Moreover, the BMI was significantly associated with distant metastasis (P = 0.04). Conclusions Obese rectal cancer patients have high DFS rates and a decreased incidence of distant metastases compared to non-obese patients. The BMI may be a key factor for predicting the postoperative prognosis and determination of an appropriate strategy for the treatment of rectal cancer patients.
| Original language | English |
|---|---|
| Journal | Surgery Today |
| DOIs | |
| Publication status | Accepted/In press - 2014 May 21 |
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Keywords
- Body mass index
- Obesity
- Postoperative recurrence
- Rectal cancer
ASJC Scopus subject areas
- Surgery
Cite this
Obesity was associated with a decreased postoperative recurrence of rectal cancer in a Japanese population. / Seishima, Ryo; Okabayashi, Koji; Hasegawa, Hirotoshi; Sugiyama, Daisuke; Ishii, Yoshiyuki; Tsuruta, Masashi; Takebayashi, Toru; Kitagawa, Yuukou.
In: Surgery Today, 21.05.2014.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Obesity was associated with a decreased postoperative recurrence of rectal cancer in a Japanese population
AU - Seishima, Ryo
AU - Okabayashi, Koji
AU - Hasegawa, Hirotoshi
AU - Sugiyama, Daisuke
AU - Ishii, Yoshiyuki
AU - Tsuruta, Masashi
AU - Takebayashi, Toru
AU - Kitagawa, Yuukou
PY - 2014/5/21
Y1 - 2014/5/21
N2 - Purpose Obesity contributes to the technical difficulty of rectal surgery and is considered to be a risk factor for postoperative complications. The impact of obesity on the long-term outcomes of rectal cancer surgery remains unclear. Methods A total of 263 consecutive rectal cancer patients who underwent surgery were categorized into two groups according to the body mass index (BMI) based on the Asian BMI classification: non-obese (BMI <25 kg/m2) and obese (BMI ≥25 kg/m2). The postoperative survival and recurrence rates and oncological surgical quality indicators were compared between groups using the univariate and multivariate analyses. The differences in recurrence patterns were assessed by a competing risk regression analysis. Results 64 (24 %) patients were included in the obese group. The number of retrieved lymph nodes was significantly greater in the non-obese group than in the obese group (22.4 vs. 16.0, P < 0.01). The 5-year disease-free survival (DFS) rates were 86.5 and 68.8 % in the obese and non-obese groups, respectively (P = 0.01). The multivariate analysis demonstrated that obesity significantly decreased the postoperative recurrence rate (P = 0.04). Moreover, the BMI was significantly associated with distant metastasis (P = 0.04). Conclusions Obese rectal cancer patients have high DFS rates and a decreased incidence of distant metastases compared to non-obese patients. The BMI may be a key factor for predicting the postoperative prognosis and determination of an appropriate strategy for the treatment of rectal cancer patients.
AB - Purpose Obesity contributes to the technical difficulty of rectal surgery and is considered to be a risk factor for postoperative complications. The impact of obesity on the long-term outcomes of rectal cancer surgery remains unclear. Methods A total of 263 consecutive rectal cancer patients who underwent surgery were categorized into two groups according to the body mass index (BMI) based on the Asian BMI classification: non-obese (BMI <25 kg/m2) and obese (BMI ≥25 kg/m2). The postoperative survival and recurrence rates and oncological surgical quality indicators were compared between groups using the univariate and multivariate analyses. The differences in recurrence patterns were assessed by a competing risk regression analysis. Results 64 (24 %) patients were included in the obese group. The number of retrieved lymph nodes was significantly greater in the non-obese group than in the obese group (22.4 vs. 16.0, P < 0.01). The 5-year disease-free survival (DFS) rates were 86.5 and 68.8 % in the obese and non-obese groups, respectively (P = 0.01). The multivariate analysis demonstrated that obesity significantly decreased the postoperative recurrence rate (P = 0.04). Moreover, the BMI was significantly associated with distant metastasis (P = 0.04). Conclusions Obese rectal cancer patients have high DFS rates and a decreased incidence of distant metastases compared to non-obese patients. The BMI may be a key factor for predicting the postoperative prognosis and determination of an appropriate strategy for the treatment of rectal cancer patients.
KW - Body mass index
KW - Obesity
KW - Postoperative recurrence
KW - Rectal cancer
UR - http://www.scopus.com/inward/record.url?scp=84901566692&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84901566692&partnerID=8YFLogxK
U2 - 10.1007/s00595-014-0899-z
DO - 10.1007/s00595-014-0899-z
M3 - Article
C2 - 24840399
AN - SCOPUS:84938881761
JO - Surgery Today
JF - Surgery Today
SN - 0941-1291
ER -