Observer variation study of the assessment and diagnosis of incidental colonic FDG uptake

Ryogo Minamimoto, Takashi Terauchi, Seishi Jinnouchi, Tsuyoshi Yoshida, Eriko Tsukamoto, Takuro Shimbo, Kimiteru Ito, Kimiichi Uno, Hitoshi Ohno, Kazuhiro Oguchi, Satoshi Kato, Koichiro Kaneko, Yoko Satoh, Tsuneo Tamaki, Tadaki Nakahara, Miyako Morooka, Tomio Inoue, Michio Senda

Research output: Contribution to journalArticle

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Abstract

Purpose: The aim of this study was to evaluate the interpretations of incidental colonic 18F-FDG uptake made by 10 experienced readers and to more clearly identify the pattern of suspicious colonic FDG uptake. The potential contributions of delayed FDG-PET scanning and of immune fecal occult blood testing (FOBT) in making a diagnosis were also analyzed. Materials and methods: Visual interpretations by 10 readers were made for 147 FDG uptake sites from 126 PET scans (cancer, 38 sites; adenoma, 43 sites; and no abnormality, 66 sites) with colonic FDG uptake. Assessments for the early FDG-PET images were (1) FDG uptake pattern, (2) FDG uptake degree, and (3) likelihood of malignancy. For the delayed images, the assessments were (1) change in the FDG uptake position, (2) change in FDG uptake degree, and (3) likelihood of malignancy. The results of FOBT were analyzed independently of the visual interpretations. Results: Interobserver agreement (κ) was 0.501 for assessing FDG uptake patterns, while agreement on assessing changes in uptake degree and changes in uptake position between early and delayed imaging were low (κ = 0.213-0.229). Logistic regression analysis indicated that 'FDG uptake patterns' and 'FDG uptake degree' were significantly related to decide on the suspicion of malignancy (p < 0.001) and the final result (p < 0.001). "Small localized" and "large irregular localized" types had a high probability of a lesion regardless of either (1) FDG uptake degree or (2) variation in the uptake between the early and the delayed image. The delayed image decreased false-positive cases for some FDG uptake patterns, but it had little impact on distinguishing clearly between "cancer or adenoma" and "normal". The addition of FOBT had little impact on the diagnosis. Conclusion: There was highest agreement among readers with respect to the recognition of specified colonic FDG uptake patterns, and this pattern recognition had the most influence on the diagnosis. "Small localized" and "large irregular localized" types had a high probability of a lesion. The addition of delayed imaging and of FOBT results to the early imaging did not have much impact on the diagnosis.

Original languageEnglish
Pages (from-to)468-477
Number of pages10
JournalAnnals of Nuclear Medicine
Volume27
Issue number5
DOIs
Publication statusPublished - 2013 Jun

Fingerprint

Observer Variation
Occult Blood
Neoplasms
Adenoma
Fluorodeoxyglucose F18
Positron-Emission Tomography
Logistic Models
Regression Analysis

Keywords

  • Colonic FDG uptake
  • Colorectal cancer
  • Dual-time-point PET
  • Fecal occult blood testing (FOBT)
  • Observer validation study
  • PET

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

Minamimoto, R., Terauchi, T., Jinnouchi, S., Yoshida, T., Tsukamoto, E., Shimbo, T., ... Senda, M. (2013). Observer variation study of the assessment and diagnosis of incidental colonic FDG uptake. Annals of Nuclear Medicine, 27(5), 468-477. https://doi.org/10.1007/s12149-013-0712-x

Observer variation study of the assessment and diagnosis of incidental colonic FDG uptake. / Minamimoto, Ryogo; Terauchi, Takashi; Jinnouchi, Seishi; Yoshida, Tsuyoshi; Tsukamoto, Eriko; Shimbo, Takuro; Ito, Kimiteru; Uno, Kimiichi; Ohno, Hitoshi; Oguchi, Kazuhiro; Kato, Satoshi; Kaneko, Koichiro; Satoh, Yoko; Tamaki, Tsuneo; Nakahara, Tadaki; Morooka, Miyako; Inoue, Tomio; Senda, Michio.

In: Annals of Nuclear Medicine, Vol. 27, No. 5, 06.2013, p. 468-477.

Research output: Contribution to journalArticle

Minamimoto, R, Terauchi, T, Jinnouchi, S, Yoshida, T, Tsukamoto, E, Shimbo, T, Ito, K, Uno, K, Ohno, H, Oguchi, K, Kato, S, Kaneko, K, Satoh, Y, Tamaki, T, Nakahara, T, Morooka, M, Inoue, T & Senda, M 2013, 'Observer variation study of the assessment and diagnosis of incidental colonic FDG uptake', Annals of Nuclear Medicine, vol. 27, no. 5, pp. 468-477. https://doi.org/10.1007/s12149-013-0712-x
Minamimoto R, Terauchi T, Jinnouchi S, Yoshida T, Tsukamoto E, Shimbo T et al. Observer variation study of the assessment and diagnosis of incidental colonic FDG uptake. Annals of Nuclear Medicine. 2013 Jun;27(5):468-477. https://doi.org/10.1007/s12149-013-0712-x
Minamimoto, Ryogo ; Terauchi, Takashi ; Jinnouchi, Seishi ; Yoshida, Tsuyoshi ; Tsukamoto, Eriko ; Shimbo, Takuro ; Ito, Kimiteru ; Uno, Kimiichi ; Ohno, Hitoshi ; Oguchi, Kazuhiro ; Kato, Satoshi ; Kaneko, Koichiro ; Satoh, Yoko ; Tamaki, Tsuneo ; Nakahara, Tadaki ; Morooka, Miyako ; Inoue, Tomio ; Senda, Michio. / Observer variation study of the assessment and diagnosis of incidental colonic FDG uptake. In: Annals of Nuclear Medicine. 2013 ; Vol. 27, No. 5. pp. 468-477.
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T1 - Observer variation study of the assessment and diagnosis of incidental colonic FDG uptake

AU - Minamimoto, Ryogo

AU - Terauchi, Takashi

AU - Jinnouchi, Seishi

AU - Yoshida, Tsuyoshi

AU - Tsukamoto, Eriko

AU - Shimbo, Takuro

AU - Ito, Kimiteru

AU - Uno, Kimiichi

AU - Ohno, Hitoshi

AU - Oguchi, Kazuhiro

AU - Kato, Satoshi

AU - Kaneko, Koichiro

AU - Satoh, Yoko

AU - Tamaki, Tsuneo

AU - Nakahara, Tadaki

AU - Morooka, Miyako

AU - Inoue, Tomio

AU - Senda, Michio

PY - 2013/6

Y1 - 2013/6

N2 - Purpose: The aim of this study was to evaluate the interpretations of incidental colonic 18F-FDG uptake made by 10 experienced readers and to more clearly identify the pattern of suspicious colonic FDG uptake. The potential contributions of delayed FDG-PET scanning and of immune fecal occult blood testing (FOBT) in making a diagnosis were also analyzed. Materials and methods: Visual interpretations by 10 readers were made for 147 FDG uptake sites from 126 PET scans (cancer, 38 sites; adenoma, 43 sites; and no abnormality, 66 sites) with colonic FDG uptake. Assessments for the early FDG-PET images were (1) FDG uptake pattern, (2) FDG uptake degree, and (3) likelihood of malignancy. For the delayed images, the assessments were (1) change in the FDG uptake position, (2) change in FDG uptake degree, and (3) likelihood of malignancy. The results of FOBT were analyzed independently of the visual interpretations. Results: Interobserver agreement (κ) was 0.501 for assessing FDG uptake patterns, while agreement on assessing changes in uptake degree and changes in uptake position between early and delayed imaging were low (κ = 0.213-0.229). Logistic regression analysis indicated that 'FDG uptake patterns' and 'FDG uptake degree' were significantly related to decide on the suspicion of malignancy (p < 0.001) and the final result (p < 0.001). "Small localized" and "large irregular localized" types had a high probability of a lesion regardless of either (1) FDG uptake degree or (2) variation in the uptake between the early and the delayed image. The delayed image decreased false-positive cases for some FDG uptake patterns, but it had little impact on distinguishing clearly between "cancer or adenoma" and "normal". The addition of FOBT had little impact on the diagnosis. Conclusion: There was highest agreement among readers with respect to the recognition of specified colonic FDG uptake patterns, and this pattern recognition had the most influence on the diagnosis. "Small localized" and "large irregular localized" types had a high probability of a lesion. The addition of delayed imaging and of FOBT results to the early imaging did not have much impact on the diagnosis.

AB - Purpose: The aim of this study was to evaluate the interpretations of incidental colonic 18F-FDG uptake made by 10 experienced readers and to more clearly identify the pattern of suspicious colonic FDG uptake. The potential contributions of delayed FDG-PET scanning and of immune fecal occult blood testing (FOBT) in making a diagnosis were also analyzed. Materials and methods: Visual interpretations by 10 readers were made for 147 FDG uptake sites from 126 PET scans (cancer, 38 sites; adenoma, 43 sites; and no abnormality, 66 sites) with colonic FDG uptake. Assessments for the early FDG-PET images were (1) FDG uptake pattern, (2) FDG uptake degree, and (3) likelihood of malignancy. For the delayed images, the assessments were (1) change in the FDG uptake position, (2) change in FDG uptake degree, and (3) likelihood of malignancy. The results of FOBT were analyzed independently of the visual interpretations. Results: Interobserver agreement (κ) was 0.501 for assessing FDG uptake patterns, while agreement on assessing changes in uptake degree and changes in uptake position between early and delayed imaging were low (κ = 0.213-0.229). Logistic regression analysis indicated that 'FDG uptake patterns' and 'FDG uptake degree' were significantly related to decide on the suspicion of malignancy (p < 0.001) and the final result (p < 0.001). "Small localized" and "large irregular localized" types had a high probability of a lesion regardless of either (1) FDG uptake degree or (2) variation in the uptake between the early and the delayed image. The delayed image decreased false-positive cases for some FDG uptake patterns, but it had little impact on distinguishing clearly between "cancer or adenoma" and "normal". The addition of FOBT had little impact on the diagnosis. Conclusion: There was highest agreement among readers with respect to the recognition of specified colonic FDG uptake patterns, and this pattern recognition had the most influence on the diagnosis. "Small localized" and "large irregular localized" types had a high probability of a lesion. The addition of delayed imaging and of FOBT results to the early imaging did not have much impact on the diagnosis.

KW - Colonic FDG uptake

KW - Colorectal cancer

KW - Dual-time-point PET

KW - Fecal occult blood testing (FOBT)

KW - Observer validation study

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