Occlusal force is correlated with cognitive function directly as well as indirectly via food intake in community-dwelling older Japanese

From the SONIC study

Kazunori Ikebe, Yasuyuki Gondo, Kei Kamide, Yukie Masui, Taturo Ishizaki, Yasumichi Arai, Hiroki Inagaki, Takeshi Nakagawa, Mai Kabayama, Hirochika Ryuno, Hitomi Okubo, Hajime Takeshita, Chisato Inomata, Yuko Kurushima, Yusuke Mihara, Kohdai Hatta, Motoyoshi Fukutake, Kaori Enoki, Taiji Ogawa, Ken ichi Matsuda & 10 others Ken Sugimoto, Ryosuke Oguro, Yoichi Takami, Norihisa Itoh, Yasushi Takeya, Koichi Yamamoto, Hiromi Rakugi, Shinya Murakami, Masahiro Kitamura, Yoshinobu Maeda

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Background Growing evidence suggests that oral health may be an important factor associated with cognitive function in aged populations. However, many previous studies on this topic used insensitive oral indicators or did not include certain essential covariates. Thus, we examined the association between occlusal force and cognitive function in a large sample of older adults, controlling for dietary intake, vascular risk factors, inflammatory biomarkers, depression, and genetic factors. Methods In this cross-sectional study of older community-dwelling Japanese adults, we examined data collected from 994 persons aged 70 years and 968 persons aged 80 years. Cognitive function was measured using the Japanese version of the Montreal Cognitive Assessment (MoCA-J). Oral status and function were evaluated according to the number of remaining teeth, periodontal pocket depth, and maximal occlusal force. Associations between MoCA-J scores and occlusal force were investigated via bivariate and multivariate analyses. Results Education level, financial status, depression score, and intake of green and yellow vegetables, as well as number of teeth and occlusal force, were significantly correlated with MoCA-J scores in both age groups. Among individuals aged 80 years, CRP and periodontal status were weakly but significantly associated with MoCA-J score. After controlling for all significant variables via bivariate analyses, the correlation between maximal occlusal force and cognitive function persisted. A path analysis confirmed the hypothesis that cognitive function is associated with occlusal force directly as well as indirectly via food intake. Conclusions After controlling for possible factors, maximal occlusal force was positively associated with cognitive function directly as well as indirectly through dietary intake.

Original languageEnglish
Article numbere0190741
JournalPLoS One
Volume13
Issue number1
DOIs
Publication statusPublished - 2018 Jan 1

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Bite Force
Independent Living
cognition
Cognition
food intake
Eating
mouth
Tooth
teeth
Depression
Periodontal Pocket
Oral Health
Vegetables
educational status
Biomarkers
blood vessels
cross-sectional studies
biomarkers
risk factors
Multivariate Analysis

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

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Occlusal force is correlated with cognitive function directly as well as indirectly via food intake in community-dwelling older Japanese : From the SONIC study. / Ikebe, Kazunori; Gondo, Yasuyuki; Kamide, Kei; Masui, Yukie; Ishizaki, Taturo; Arai, Yasumichi; Inagaki, Hiroki; Nakagawa, Takeshi; Kabayama, Mai; Ryuno, Hirochika; Okubo, Hitomi; Takeshita, Hajime; Inomata, Chisato; Kurushima, Yuko; Mihara, Yusuke; Hatta, Kohdai; Fukutake, Motoyoshi; Enoki, Kaori; Ogawa, Taiji; Matsuda, Ken ichi; Sugimoto, Ken; Oguro, Ryosuke; Takami, Yoichi; Itoh, Norihisa; Takeya, Yasushi; Yamamoto, Koichi; Rakugi, Hiromi; Murakami, Shinya; Kitamura, Masahiro; Maeda, Yoshinobu.

In: PLoS One, Vol. 13, No. 1, e0190741, 01.01.2018.

Research output: Contribution to journalArticle

Ikebe, K, Gondo, Y, Kamide, K, Masui, Y, Ishizaki, T, Arai, Y, Inagaki, H, Nakagawa, T, Kabayama, M, Ryuno, H, Okubo, H, Takeshita, H, Inomata, C, Kurushima, Y, Mihara, Y, Hatta, K, Fukutake, M, Enoki, K, Ogawa, T, Matsuda, KI, Sugimoto, K, Oguro, R, Takami, Y, Itoh, N, Takeya, Y, Yamamoto, K, Rakugi, H, Murakami, S, Kitamura, M & Maeda, Y 2018, 'Occlusal force is correlated with cognitive function directly as well as indirectly via food intake in community-dwelling older Japanese: From the SONIC study', PLoS One, vol. 13, no. 1, e0190741. https://doi.org/10.1371/journal.pone.0190741
Ikebe, Kazunori ; Gondo, Yasuyuki ; Kamide, Kei ; Masui, Yukie ; Ishizaki, Taturo ; Arai, Yasumichi ; Inagaki, Hiroki ; Nakagawa, Takeshi ; Kabayama, Mai ; Ryuno, Hirochika ; Okubo, Hitomi ; Takeshita, Hajime ; Inomata, Chisato ; Kurushima, Yuko ; Mihara, Yusuke ; Hatta, Kohdai ; Fukutake, Motoyoshi ; Enoki, Kaori ; Ogawa, Taiji ; Matsuda, Ken ichi ; Sugimoto, Ken ; Oguro, Ryosuke ; Takami, Yoichi ; Itoh, Norihisa ; Takeya, Yasushi ; Yamamoto, Koichi ; Rakugi, Hiromi ; Murakami, Shinya ; Kitamura, Masahiro ; Maeda, Yoshinobu. / Occlusal force is correlated with cognitive function directly as well as indirectly via food intake in community-dwelling older Japanese : From the SONIC study. In: PLoS One. 2018 ; Vol. 13, No. 1.
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abstract = "Background Growing evidence suggests that oral health may be an important factor associated with cognitive function in aged populations. However, many previous studies on this topic used insensitive oral indicators or did not include certain essential covariates. Thus, we examined the association between occlusal force and cognitive function in a large sample of older adults, controlling for dietary intake, vascular risk factors, inflammatory biomarkers, depression, and genetic factors. Methods In this cross-sectional study of older community-dwelling Japanese adults, we examined data collected from 994 persons aged 70 years and 968 persons aged 80 years. Cognitive function was measured using the Japanese version of the Montreal Cognitive Assessment (MoCA-J). Oral status and function were evaluated according to the number of remaining teeth, periodontal pocket depth, and maximal occlusal force. Associations between MoCA-J scores and occlusal force were investigated via bivariate and multivariate analyses. Results Education level, financial status, depression score, and intake of green and yellow vegetables, as well as number of teeth and occlusal force, were significantly correlated with MoCA-J scores in both age groups. Among individuals aged 80 years, CRP and periodontal status were weakly but significantly associated with MoCA-J score. After controlling for all significant variables via bivariate analyses, the correlation between maximal occlusal force and cognitive function persisted. A path analysis confirmed the hypothesis that cognitive function is associated with occlusal force directly as well as indirectly via food intake. Conclusions After controlling for possible factors, maximal occlusal force was positively associated with cognitive function directly as well as indirectly through dietary intake.",
author = "Kazunori Ikebe and Yasuyuki Gondo and Kei Kamide and Yukie Masui and Taturo Ishizaki and Yasumichi Arai and Hiroki Inagaki and Takeshi Nakagawa and Mai Kabayama and Hirochika Ryuno and Hitomi Okubo and Hajime Takeshita and Chisato Inomata and Yuko Kurushima and Yusuke Mihara and Kohdai Hatta and Motoyoshi Fukutake and Kaori Enoki and Taiji Ogawa and Matsuda, {Ken ichi} and Ken Sugimoto and Ryosuke Oguro and Yoichi Takami and Norihisa Itoh and Yasushi Takeya and Koichi Yamamoto and Hiromi Rakugi and Shinya Murakami and Masahiro Kitamura and Yoshinobu Maeda",
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T1 - Occlusal force is correlated with cognitive function directly as well as indirectly via food intake in community-dwelling older Japanese

T2 - From the SONIC study

AU - Ikebe, Kazunori

AU - Gondo, Yasuyuki

AU - Kamide, Kei

AU - Masui, Yukie

AU - Ishizaki, Taturo

AU - Arai, Yasumichi

AU - Inagaki, Hiroki

AU - Nakagawa, Takeshi

AU - Kabayama, Mai

AU - Ryuno, Hirochika

AU - Okubo, Hitomi

AU - Takeshita, Hajime

AU - Inomata, Chisato

AU - Kurushima, Yuko

AU - Mihara, Yusuke

AU - Hatta, Kohdai

AU - Fukutake, Motoyoshi

AU - Enoki, Kaori

AU - Ogawa, Taiji

AU - Matsuda, Ken ichi

AU - Sugimoto, Ken

AU - Oguro, Ryosuke

AU - Takami, Yoichi

AU - Itoh, Norihisa

AU - Takeya, Yasushi

AU - Yamamoto, Koichi

AU - Rakugi, Hiromi

AU - Murakami, Shinya

AU - Kitamura, Masahiro

AU - Maeda, Yoshinobu

PY - 2018/1/1

Y1 - 2018/1/1

N2 - Background Growing evidence suggests that oral health may be an important factor associated with cognitive function in aged populations. However, many previous studies on this topic used insensitive oral indicators or did not include certain essential covariates. Thus, we examined the association between occlusal force and cognitive function in a large sample of older adults, controlling for dietary intake, vascular risk factors, inflammatory biomarkers, depression, and genetic factors. Methods In this cross-sectional study of older community-dwelling Japanese adults, we examined data collected from 994 persons aged 70 years and 968 persons aged 80 years. Cognitive function was measured using the Japanese version of the Montreal Cognitive Assessment (MoCA-J). Oral status and function were evaluated according to the number of remaining teeth, periodontal pocket depth, and maximal occlusal force. Associations between MoCA-J scores and occlusal force were investigated via bivariate and multivariate analyses. Results Education level, financial status, depression score, and intake of green and yellow vegetables, as well as number of teeth and occlusal force, were significantly correlated with MoCA-J scores in both age groups. Among individuals aged 80 years, CRP and periodontal status were weakly but significantly associated with MoCA-J score. After controlling for all significant variables via bivariate analyses, the correlation between maximal occlusal force and cognitive function persisted. A path analysis confirmed the hypothesis that cognitive function is associated with occlusal force directly as well as indirectly via food intake. Conclusions After controlling for possible factors, maximal occlusal force was positively associated with cognitive function directly as well as indirectly through dietary intake.

AB - Background Growing evidence suggests that oral health may be an important factor associated with cognitive function in aged populations. However, many previous studies on this topic used insensitive oral indicators or did not include certain essential covariates. Thus, we examined the association between occlusal force and cognitive function in a large sample of older adults, controlling for dietary intake, vascular risk factors, inflammatory biomarkers, depression, and genetic factors. Methods In this cross-sectional study of older community-dwelling Japanese adults, we examined data collected from 994 persons aged 70 years and 968 persons aged 80 years. Cognitive function was measured using the Japanese version of the Montreal Cognitive Assessment (MoCA-J). Oral status and function were evaluated according to the number of remaining teeth, periodontal pocket depth, and maximal occlusal force. Associations between MoCA-J scores and occlusal force were investigated via bivariate and multivariate analyses. Results Education level, financial status, depression score, and intake of green and yellow vegetables, as well as number of teeth and occlusal force, were significantly correlated with MoCA-J scores in both age groups. Among individuals aged 80 years, CRP and periodontal status were weakly but significantly associated with MoCA-J score. After controlling for all significant variables via bivariate analyses, the correlation between maximal occlusal force and cognitive function persisted. A path analysis confirmed the hypothesis that cognitive function is associated with occlusal force directly as well as indirectly via food intake. Conclusions After controlling for possible factors, maximal occlusal force was positively associated with cognitive function directly as well as indirectly through dietary intake.

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