Occlusal force predicted cognitive decline among 70- and 80-year-old Japanese: A 3-year prospective cohort study

Kodai Hatta, Yasuyuki Gondo, Kei Kamide, Yukie Masui, Hiroki Inagaki, Takeshi Nakagawa, Ken ichi Matsuda, Chisato Inomata, Hajime Takeshita, Yusuke Mihara, Motoyoshi Fukutake, Masahiro Kitamura, Shinya Murakami, Mai Kabayama, Tatsuro Ishizaki, Yasumichi Arai, Ken Sugimoto, Hiromi Rakugi, Yoshinobu Maeda, Kazunori Ikebe

Research output: Contribution to journalArticle

Abstract

Purpose: Dementia is a growing health problem for countries with aging populations, but few effective dementia treatments are available. However, there is increasing interest in oral health as a modifiable risk factor in interventions to prevent cognitive decline. This study aimed to investigate the impact of oral health on the decline of cognitive function over 3 years among Japanese people aged 70 and 80 years. Methods: Participants (n = 860) were community-dwelling older adults who participated in baseline and follow-up surveys (at baseline: 69–71 years n = 423; 79–81 years, n = 437). Registered dentists examined the number of teeth, number of functional teeth, number of periodontal teeth, and occlusal force. The Japanese version of the Montreal Cognitive Assessment was used to evaluate cognitive function. We also evaluated socioeconomic factors, medical history, drinking and smoking habits, physical performance, genetic factors, and C-reactive protein concentration in blood. A generalized estimating equation (GEE) was used to examine how oral health at baseline influenced cognitive decline over 3 years. Results: The GEE showed that the number of teeth (non-standardized coefficient: B = 0.031, p = 0.022) and occlusal force (B = 0.103, p = 0.004) at baseline were associated with cognitive function at follow-up, even after adjusting for other risk factors. Furthermore, maintaining more teeth (B = 0.009, p = 0.004) and a stronger occlusal force (B = 0.020, p = 0.040) buffered cognitive decline. Conclusions: Number of teeth and occlusal force predict cognitive decline over 3 subsequent years in Japanese older adults aged 70 and 80 years.

Original languageEnglish
JournalJournal of Prosthodontic Research
DOIs
Publication statusAccepted/In press - 2019 Jan 1

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Bite Force
Tooth
Cohort Studies
Prospective Studies
Oral Health
Cognition
Dementia
Independent Living
Dentists
C-Reactive Protein
Drinking
Habits
Cognitive Dysfunction
Smoking
Health
Population

Keywords

  • Cognitive decline
  • Cohort study
  • Gerodontology
  • Occlusal force

ASJC Scopus subject areas

  • Oral Surgery
  • Dentistry (miscellaneous)

Cite this

Occlusal force predicted cognitive decline among 70- and 80-year-old Japanese : A 3-year prospective cohort study. / Hatta, Kodai; Gondo, Yasuyuki; Kamide, Kei; Masui, Yukie; Inagaki, Hiroki; Nakagawa, Takeshi; Matsuda, Ken ichi; Inomata, Chisato; Takeshita, Hajime; Mihara, Yusuke; Fukutake, Motoyoshi; Kitamura, Masahiro; Murakami, Shinya; Kabayama, Mai; Ishizaki, Tatsuro; Arai, Yasumichi; Sugimoto, Ken; Rakugi, Hiromi; Maeda, Yoshinobu; Ikebe, Kazunori.

In: Journal of Prosthodontic Research, 01.01.2019.

Research output: Contribution to journalArticle

Hatta, K, Gondo, Y, Kamide, K, Masui, Y, Inagaki, H, Nakagawa, T, Matsuda, KI, Inomata, C, Takeshita, H, Mihara, Y, Fukutake, M, Kitamura, M, Murakami, S, Kabayama, M, Ishizaki, T, Arai, Y, Sugimoto, K, Rakugi, H, Maeda, Y & Ikebe, K 2019, 'Occlusal force predicted cognitive decline among 70- and 80-year-old Japanese: A 3-year prospective cohort study', Journal of Prosthodontic Research. https://doi.org/10.1016/j.jpor.2019.07.002
Hatta, Kodai ; Gondo, Yasuyuki ; Kamide, Kei ; Masui, Yukie ; Inagaki, Hiroki ; Nakagawa, Takeshi ; Matsuda, Ken ichi ; Inomata, Chisato ; Takeshita, Hajime ; Mihara, Yusuke ; Fukutake, Motoyoshi ; Kitamura, Masahiro ; Murakami, Shinya ; Kabayama, Mai ; Ishizaki, Tatsuro ; Arai, Yasumichi ; Sugimoto, Ken ; Rakugi, Hiromi ; Maeda, Yoshinobu ; Ikebe, Kazunori. / Occlusal force predicted cognitive decline among 70- and 80-year-old Japanese : A 3-year prospective cohort study. In: Journal of Prosthodontic Research. 2019.
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abstract = "Purpose: Dementia is a growing health problem for countries with aging populations, but few effective dementia treatments are available. However, there is increasing interest in oral health as a modifiable risk factor in interventions to prevent cognitive decline. This study aimed to investigate the impact of oral health on the decline of cognitive function over 3 years among Japanese people aged 70 and 80 years. Methods: Participants (n = 860) were community-dwelling older adults who participated in baseline and follow-up surveys (at baseline: 69–71 years n = 423; 79–81 years, n = 437). Registered dentists examined the number of teeth, number of functional teeth, number of periodontal teeth, and occlusal force. The Japanese version of the Montreal Cognitive Assessment was used to evaluate cognitive function. We also evaluated socioeconomic factors, medical history, drinking and smoking habits, physical performance, genetic factors, and C-reactive protein concentration in blood. A generalized estimating equation (GEE) was used to examine how oral health at baseline influenced cognitive decline over 3 years. Results: The GEE showed that the number of teeth (non-standardized coefficient: B = 0.031, p = 0.022) and occlusal force (B = 0.103, p = 0.004) at baseline were associated with cognitive function at follow-up, even after adjusting for other risk factors. Furthermore, maintaining more teeth (B = 0.009, p = 0.004) and a stronger occlusal force (B = 0.020, p = 0.040) buffered cognitive decline. Conclusions: Number of teeth and occlusal force predict cognitive decline over 3 subsequent years in Japanese older adults aged 70 and 80 years.",
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T1 - Occlusal force predicted cognitive decline among 70- and 80-year-old Japanese

T2 - A 3-year prospective cohort study

AU - Hatta, Kodai

AU - Gondo, Yasuyuki

AU - Kamide, Kei

AU - Masui, Yukie

AU - Inagaki, Hiroki

AU - Nakagawa, Takeshi

AU - Matsuda, Ken ichi

AU - Inomata, Chisato

AU - Takeshita, Hajime

AU - Mihara, Yusuke

AU - Fukutake, Motoyoshi

AU - Kitamura, Masahiro

AU - Murakami, Shinya

AU - Kabayama, Mai

AU - Ishizaki, Tatsuro

AU - Arai, Yasumichi

AU - Sugimoto, Ken

AU - Rakugi, Hiromi

AU - Maeda, Yoshinobu

AU - Ikebe, Kazunori

PY - 2019/1/1

Y1 - 2019/1/1

N2 - Purpose: Dementia is a growing health problem for countries with aging populations, but few effective dementia treatments are available. However, there is increasing interest in oral health as a modifiable risk factor in interventions to prevent cognitive decline. This study aimed to investigate the impact of oral health on the decline of cognitive function over 3 years among Japanese people aged 70 and 80 years. Methods: Participants (n = 860) were community-dwelling older adults who participated in baseline and follow-up surveys (at baseline: 69–71 years n = 423; 79–81 years, n = 437). Registered dentists examined the number of teeth, number of functional teeth, number of periodontal teeth, and occlusal force. The Japanese version of the Montreal Cognitive Assessment was used to evaluate cognitive function. We also evaluated socioeconomic factors, medical history, drinking and smoking habits, physical performance, genetic factors, and C-reactive protein concentration in blood. A generalized estimating equation (GEE) was used to examine how oral health at baseline influenced cognitive decline over 3 years. Results: The GEE showed that the number of teeth (non-standardized coefficient: B = 0.031, p = 0.022) and occlusal force (B = 0.103, p = 0.004) at baseline were associated with cognitive function at follow-up, even after adjusting for other risk factors. Furthermore, maintaining more teeth (B = 0.009, p = 0.004) and a stronger occlusal force (B = 0.020, p = 0.040) buffered cognitive decline. Conclusions: Number of teeth and occlusal force predict cognitive decline over 3 subsequent years in Japanese older adults aged 70 and 80 years.

AB - Purpose: Dementia is a growing health problem for countries with aging populations, but few effective dementia treatments are available. However, there is increasing interest in oral health as a modifiable risk factor in interventions to prevent cognitive decline. This study aimed to investigate the impact of oral health on the decline of cognitive function over 3 years among Japanese people aged 70 and 80 years. Methods: Participants (n = 860) were community-dwelling older adults who participated in baseline and follow-up surveys (at baseline: 69–71 years n = 423; 79–81 years, n = 437). Registered dentists examined the number of teeth, number of functional teeth, number of periodontal teeth, and occlusal force. The Japanese version of the Montreal Cognitive Assessment was used to evaluate cognitive function. We also evaluated socioeconomic factors, medical history, drinking and smoking habits, physical performance, genetic factors, and C-reactive protein concentration in blood. A generalized estimating equation (GEE) was used to examine how oral health at baseline influenced cognitive decline over 3 years. Results: The GEE showed that the number of teeth (non-standardized coefficient: B = 0.031, p = 0.022) and occlusal force (B = 0.103, p = 0.004) at baseline were associated with cognitive function at follow-up, even after adjusting for other risk factors. Furthermore, maintaining more teeth (B = 0.009, p = 0.004) and a stronger occlusal force (B = 0.020, p = 0.040) buffered cognitive decline. Conclusions: Number of teeth and occlusal force predict cognitive decline over 3 subsequent years in Japanese older adults aged 70 and 80 years.

KW - Cognitive decline

KW - Cohort study

KW - Gerodontology

KW - Occlusal force

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