Occurrence of a community with high morbidity associated with Schistosoma mansoni infection regardless of low infection intensity in north-east Brazil

Masanobu Tanabe, José Felip Gonçalves, Fernando José Gonçalves, Seiki Tateno, Tsutomu Takeuchi

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

To establish the relationship between schistosome-associated morbidity and infection intensity in northeast Brazil, a parasitological and ultrasonographical study was carried out on 484 inhabitants of 4 villages (I, II, III and IV) in Sao Lourenco da Mata, Pernambuco, Brazil, where schistosomiasis is endemic. Quantitative stool examination using Knight's method demonstrated a high prevalence and moderate intensity of Schistosoma mansoni infection, and also that the subjects in village IV had a significantly lower prevalence and intensity of infection than those of the other villages. By ultrasonography, periportal fibrosis (PPF) and splenomegaly were found in 52% of the 299 infected subjects and 66% of the 146 infected subjects aged over 16 years old, respectively; 32% and 31% of the 299 infected subjects had abnormally high values of total bile acid (TBA) and alkaline phosphatase (ALP) activity, respectively. Liver and spleen size, PPF, and serum level of TBA and ALP were not correlated with infection intensity. There was no significant difference in the morbidity assessed by liver and spleen size, PPF, and serum analysis between the subjects in village IV and the other villages. These findings suggest the occurrence of a community with high morbidity associated with schistosomiasis regardless of low infection intensity.

Original languageEnglish
Pages (from-to)144-149
Number of pages6
JournalTransactions of the Royal Society of Tropical Medicine and Hygiene
Volume91
Issue number2
Publication statusPublished - 1997

Fingerprint

Schistosomiasis mansoni
Brazil
Morbidity
Fibrosis
Schistosomiasis
Acid Phosphatase
Infection
Bile Acids and Salts
Alkaline Phosphatase
Spleen
Liver
Splenomegaly
Serum
Ultrasonography

Keywords

  • Infection intensity
  • Morbidity
  • Periportal fibrosis
  • Schistosoma mansoni
  • Schistosomiasis
  • Ultrasonography

ASJC Scopus subject areas

  • Parasitology
  • Medicine(all)

Cite this

Occurrence of a community with high morbidity associated with Schistosoma mansoni infection regardless of low infection intensity in north-east Brazil. / Tanabe, Masanobu; Gonçalves, José Felip; Gonçalves, Fernando José; Tateno, Seiki; Takeuchi, Tsutomu.

In: Transactions of the Royal Society of Tropical Medicine and Hygiene, Vol. 91, No. 2, 1997, p. 144-149.

Research output: Contribution to journalArticle

Tanabe, Masanobu ; Gonçalves, José Felip ; Gonçalves, Fernando José ; Tateno, Seiki ; Takeuchi, Tsutomu. / Occurrence of a community with high morbidity associated with Schistosoma mansoni infection regardless of low infection intensity in north-east Brazil. In: Transactions of the Royal Society of Tropical Medicine and Hygiene. 1997 ; Vol. 91, No. 2. pp. 144-149.
@article{7874c9dd290f410cb220298aff46edd5,
title = "Occurrence of a community with high morbidity associated with Schistosoma mansoni infection regardless of low infection intensity in north-east Brazil",
abstract = "To establish the relationship between schistosome-associated morbidity and infection intensity in northeast Brazil, a parasitological and ultrasonographical study was carried out on 484 inhabitants of 4 villages (I, II, III and IV) in Sao Lourenco da Mata, Pernambuco, Brazil, where schistosomiasis is endemic. Quantitative stool examination using Knight's method demonstrated a high prevalence and moderate intensity of Schistosoma mansoni infection, and also that the subjects in village IV had a significantly lower prevalence and intensity of infection than those of the other villages. By ultrasonography, periportal fibrosis (PPF) and splenomegaly were found in 52{\%} of the 299 infected subjects and 66{\%} of the 146 infected subjects aged over 16 years old, respectively; 32{\%} and 31{\%} of the 299 infected subjects had abnormally high values of total bile acid (TBA) and alkaline phosphatase (ALP) activity, respectively. Liver and spleen size, PPF, and serum level of TBA and ALP were not correlated with infection intensity. There was no significant difference in the morbidity assessed by liver and spleen size, PPF, and serum analysis between the subjects in village IV and the other villages. These findings suggest the occurrence of a community with high morbidity associated with schistosomiasis regardless of low infection intensity.",
keywords = "Infection intensity, Morbidity, Periportal fibrosis, Schistosoma mansoni, Schistosomiasis, Ultrasonography",
author = "Masanobu Tanabe and Gon{\cc}alves, {Jos{\'e} Felip} and Gon{\cc}alves, {Fernando Jos{\'e}} and Seiki Tateno and Tsutomu Takeuchi",
year = "1997",
language = "English",
volume = "91",
pages = "144--149",
journal = "Transactions of the Royal Society of Tropical Medicine and Hygiene",
issn = "0035-9203",
publisher = "Elsevier",
number = "2",

}

TY - JOUR

T1 - Occurrence of a community with high morbidity associated with Schistosoma mansoni infection regardless of low infection intensity in north-east Brazil

AU - Tanabe, Masanobu

AU - Gonçalves, José Felip

AU - Gonçalves, Fernando José

AU - Tateno, Seiki

AU - Takeuchi, Tsutomu

PY - 1997

Y1 - 1997

N2 - To establish the relationship between schistosome-associated morbidity and infection intensity in northeast Brazil, a parasitological and ultrasonographical study was carried out on 484 inhabitants of 4 villages (I, II, III and IV) in Sao Lourenco da Mata, Pernambuco, Brazil, where schistosomiasis is endemic. Quantitative stool examination using Knight's method demonstrated a high prevalence and moderate intensity of Schistosoma mansoni infection, and also that the subjects in village IV had a significantly lower prevalence and intensity of infection than those of the other villages. By ultrasonography, periportal fibrosis (PPF) and splenomegaly were found in 52% of the 299 infected subjects and 66% of the 146 infected subjects aged over 16 years old, respectively; 32% and 31% of the 299 infected subjects had abnormally high values of total bile acid (TBA) and alkaline phosphatase (ALP) activity, respectively. Liver and spleen size, PPF, and serum level of TBA and ALP were not correlated with infection intensity. There was no significant difference in the morbidity assessed by liver and spleen size, PPF, and serum analysis between the subjects in village IV and the other villages. These findings suggest the occurrence of a community with high morbidity associated with schistosomiasis regardless of low infection intensity.

AB - To establish the relationship between schistosome-associated morbidity and infection intensity in northeast Brazil, a parasitological and ultrasonographical study was carried out on 484 inhabitants of 4 villages (I, II, III and IV) in Sao Lourenco da Mata, Pernambuco, Brazil, where schistosomiasis is endemic. Quantitative stool examination using Knight's method demonstrated a high prevalence and moderate intensity of Schistosoma mansoni infection, and also that the subjects in village IV had a significantly lower prevalence and intensity of infection than those of the other villages. By ultrasonography, periportal fibrosis (PPF) and splenomegaly were found in 52% of the 299 infected subjects and 66% of the 146 infected subjects aged over 16 years old, respectively; 32% and 31% of the 299 infected subjects had abnormally high values of total bile acid (TBA) and alkaline phosphatase (ALP) activity, respectively. Liver and spleen size, PPF, and serum level of TBA and ALP were not correlated with infection intensity. There was no significant difference in the morbidity assessed by liver and spleen size, PPF, and serum analysis between the subjects in village IV and the other villages. These findings suggest the occurrence of a community with high morbidity associated with schistosomiasis regardless of low infection intensity.

KW - Infection intensity

KW - Morbidity

KW - Periportal fibrosis

KW - Schistosoma mansoni

KW - Schistosomiasis

KW - Ultrasonography

UR - http://www.scopus.com/inward/record.url?scp=0030946614&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0030946614&partnerID=8YFLogxK

M3 - Article

VL - 91

SP - 144

EP - 149

JO - Transactions of the Royal Society of Tropical Medicine and Hygiene

JF - Transactions of the Royal Society of Tropical Medicine and Hygiene

SN - 0035-9203

IS - 2

ER -