Occurrence of tris(4-chlorophenyl)methane, tris(4-chlorophenyl)methanol, and some other persistent organochlorines in Japanese human adipose tissue

Tu Binh Minh, Mafumi Watanabe, Shinsuke Tanabe, Taketo Yamada, Jun Ichi Hata, Shaw Watanabe

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Tris(4-chlorophenyl)methane (TCPMe) and tris(4-chlorophenyl)methanol (TCPMOH) are among the most recently identified environmental contaminants. Despite their widespread contamination in the marine environment, human exposure to these compounds remains relatively unknown. We determined the concentrations of TCPMe, TCPMOH, and other-persistent organochlorines such as polychlorinated biphenyls (PCBs), DDT and its metabolites, hexachloro-cyclohexane isomers, hexachlorobenzene, and chlordane compounds (CHLs) in human adipose tissue from Japan. TCPMe and TCPMOH were detected in all of the adipose samples analyzed; the concentrations ranged from 2.5-21 and 1.1-18 ng/g lipid weight, respectively. Concentration of TCPMe and TCPMOH in humans were less than those reported in marine mammals, suggesting the possibility of metabolism and elimination of these compounds by humans. Significant correlation between TCPMe and TCPMOH with concentrations of DDT and its metabolites in human adipose tissues suggested that exposure to DDT is the source of TCPMe and TCPMOH in humans. The age- and sex-dependent accumulation of TCPMe and TCPMOH as well as other organochlorines was less pronounced. Results for other organochlorines indicated that recent contamination status of PCBs in human samples from Japan was higher than that in developing countries, whereas DDT contamination is lower. Greater concentrations continuous monitoring of CHLs in humans in Japan is necessary. To our knowledge, this is the first study on the accumulation of TCPMe and TCPMOH in human adipose tissue.

Original languageEnglish
Pages (from-to)599-603
Number of pages5
JournalEnvironmental Health Perspectives
Volume108
Issue number7
Publication statusPublished - 2000

Fingerprint

organochlorine
methanol
Adipose Tissue
methane
Tissue
DDT
Contamination
Polychlorinated Biphenyls
Japan
Metabolites
PCB
metabolite
Chlordan
Hexachlorobenzene
Mammals
chlordane
tissue
tris(4-chlorophenyl)methane
tris(4-chlorophenyl)methanol
hexachlorobenzene

Keywords

  • Humans
  • Metabolic capacity
  • Organochlorines
  • Tris(4-chlorophenyl)methane
  • Tris(4-chlorophenyl)methanol

ASJC Scopus subject areas

  • Environmental Science(all)
  • Environmental Chemistry
  • Public Health, Environmental and Occupational Health

Cite this

Occurrence of tris(4-chlorophenyl)methane, tris(4-chlorophenyl)methanol, and some other persistent organochlorines in Japanese human adipose tissue. / Minh, Tu Binh; Watanabe, Mafumi; Tanabe, Shinsuke; Yamada, Taketo; Hata, Jun Ichi; Watanabe, Shaw.

In: Environmental Health Perspectives, Vol. 108, No. 7, 2000, p. 599-603.

Research output: Contribution to journalArticle

Minh, Tu Binh ; Watanabe, Mafumi ; Tanabe, Shinsuke ; Yamada, Taketo ; Hata, Jun Ichi ; Watanabe, Shaw. / Occurrence of tris(4-chlorophenyl)methane, tris(4-chlorophenyl)methanol, and some other persistent organochlorines in Japanese human adipose tissue. In: Environmental Health Perspectives. 2000 ; Vol. 108, No. 7. pp. 599-603.
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AU - Minh, Tu Binh

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AU - Yamada, Taketo

AU - Hata, Jun Ichi

AU - Watanabe, Shaw

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AB - Tris(4-chlorophenyl)methane (TCPMe) and tris(4-chlorophenyl)methanol (TCPMOH) are among the most recently identified environmental contaminants. Despite their widespread contamination in the marine environment, human exposure to these compounds remains relatively unknown. We determined the concentrations of TCPMe, TCPMOH, and other-persistent organochlorines such as polychlorinated biphenyls (PCBs), DDT and its metabolites, hexachloro-cyclohexane isomers, hexachlorobenzene, and chlordane compounds (CHLs) in human adipose tissue from Japan. TCPMe and TCPMOH were detected in all of the adipose samples analyzed; the concentrations ranged from 2.5-21 and 1.1-18 ng/g lipid weight, respectively. Concentration of TCPMe and TCPMOH in humans were less than those reported in marine mammals, suggesting the possibility of metabolism and elimination of these compounds by humans. Significant correlation between TCPMe and TCPMOH with concentrations of DDT and its metabolites in human adipose tissues suggested that exposure to DDT is the source of TCPMe and TCPMOH in humans. The age- and sex-dependent accumulation of TCPMe and TCPMOH as well as other organochlorines was less pronounced. Results for other organochlorines indicated that recent contamination status of PCBs in human samples from Japan was higher than that in developing countries, whereas DDT contamination is lower. Greater concentrations continuous monitoring of CHLs in humans in Japan is necessary. To our knowledge, this is the first study on the accumulation of TCPMe and TCPMOH in human adipose tissue.

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