Octreotide acetate successfully treated a bowel obstruction caused by peritoneally disseminated gastric cancer, thereby enabling the subsequent use of oral S-1 chemotherapy

Koshi Kumagai, Yoshirou Saikawa, Kazumasa Fukuda, Ryo Ito, Takahiro Igarashi, Shinichi Tsuwano, Rieko Nakamura, Tsunehiro Takahashi, Hiroya Takeuchi, Yuko Kitagawa

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

A 68-year-old woman presented with severe bowel obstruction and was subsequently diagnosed with stage IV gastric cancer with peritoneal dissemination. She was immediately stabilized in the hospital with the placement of a nasointestinal tube. Abdominal computed tomography showed multiple intraperitoneal nodules consistent with peritoneal dissemination of the gastric cancer. The patient's inability to tolerate oral intake was a contraindication to using S-1 chemotherapy, currently one of the most effective medications used for gastric cancer in Japan. Therefore, she was initially treated with octreotide acetate (OA). Her bowel obstruction was sufficiently attenuated on the seventh day after the initiation of treatment with OA to permit the initiation of oral S-1, along with low-dose cisplatin (CDDP) and radiation. S-1 was orally administered at a dose of 100 mg/day per body (80 mg/m2 per day) on days 1-28, and CDDP was infused at a dose of 7.8 mg/day per body (6 mg/m2 per day) on days 1-5, 8-12, and 15-19. Radiation therapy (2 Gy/day for 5 days/week) was performed with the chemotherapy. Despite no change being shown on her imaging findings with the chemotherapy, the patient's bowel obstruction resolved and she was able to tolerate both liquids and solid food orally. She was discharged 2 months after admission. Seven months after beginning the chemotherapy, she was still doing well on outpatient chemotherapy with S-1 and CDDP, and had no decline in her quality of life or progression of her disease.

Original languageEnglish
Pages (from-to)372-375
Number of pages4
JournalInternational Journal of Clinical Oncology
Volume14
Issue number4
DOIs
Publication statusPublished - 2009 Aug

Keywords

  • Chemoradiotherapy
  • Gastric cancer
  • Malignant bowel obstruction
  • Octreotide acetate
  • S-1

ASJC Scopus subject areas

  • Surgery
  • Hematology
  • Oncology

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