Ocular Behçet's disease is less complicated with allergic disorders. A nationwide survey in Japan

Yukihiro Horie, Nobuyoshi Kitaichi, Kuniaki Hijioka, Koh Hei Sonoda, Yoshitsugu Saishin, Takeshi Kezuka, Hiroshi Goto, Masaru Takeuchi, Satoshi Nakamura, Takashi Kimoto, Machiko Shimakawa, Mihori Kita, Sunao Sugita, Manabu Mochizuki, Junko Hori, Mitsuhiro Iwata, Jun Shoji, Masahide Fukuda, Toshikatsu Kaburaki, Jiro NumagaHidetoshi Kawashima, Astuki Fukushima, Takeshi Joko, Nanae Takai, Yoko Ozawa, Akira Meguro, Nobuhisa Mizuki, Kenichi Namba, Susumu Ishida, Shigeaki Ohno

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Objective. Behçet's disease (BD) is a systemic inflammatory disorder polarised to the Th1 and Th17 immune systems. Allergic diseases are polarised to the Th2 immune system. The aim of the present study is to investigate the prevalence of allergic diseases in patients who have BD. Methods. The study involved a largescale interview survey of Japanese patients with BD at 21 institutes of ophthalmology; 353 patients (255 males and 98 females) were recruited for this study. We analysed the history of allergic diseases such as atopic dermatitis (AD), allergic rhinitis (AR), bronchial asthma (BA) and drug/food allergies (FA). Results. Oral aphthous ulcers, ocular lesions, skin lesions, genital ulcers, arthritis, neurological lesions, intestinal lesions, deep vein thrombosis and epididymitis were reported in 95.8%, 98.6%, 72.5%, 44.8%, 13.9%, 6.8%, 6.2%, 3.7% and 1.4% of the patients, respectively. It was also reported that 73 patients (20.7%) had histories of allergic diseases: AD (5 cases, 1.4%), AR (36 cases, 10.2%), BA (19 cases, 5.4%) and FA (30 cases, 8.5%). This percentage was significantly lower than in a survey that Japan's Ministry of Health, Labour and Welfare conducted for healthy population (47.6%) (odds ratio = 0.29, 95% confidence interval = 0.22-0.38, p=4.9×10-22). Frequencies of posterior/pan-uveitis, relatively severe ocular findings, and visual prognosis were not affected by a history of allergic diseases in BD. Conclusion. Patients with BD had fewer complications from allergic diseases than did the entire population of Japan.

Original languageEnglish
Pages (from-to)111-114
Number of pages4
JournalClinical and Experimental Rheumatology
Volume34
Publication statusPublished - 2016

Fingerprint

Eye Diseases
Japan
Food Hypersensitivity
Immune System
Surveys and Questionnaires
Asthma
Posterior Uveitis
Oral Ulcer
Epididymitis
Aphthous Stomatitis
Drug Hypersensitivity
Ophthalmology
Atopic Dermatitis
Venous Thrombosis
Population
Ulcer
Arthritis
History
Odds Ratio
Confidence Intervals

Keywords

  • Allergic diseases
  • Behçet's disease
  • Silk Road disease
  • Th1
  • Th2

ASJC Scopus subject areas

  • Immunology and Allergy
  • Rheumatology
  • Immunology

Cite this

Horie, Y., Kitaichi, N., Hijioka, K., Sonoda, K. H., Saishin, Y., Kezuka, T., ... Ohno, S. (2016). Ocular Behçet's disease is less complicated with allergic disorders. A nationwide survey in Japan. Clinical and Experimental Rheumatology, 34, 111-114.

Ocular Behçet's disease is less complicated with allergic disorders. A nationwide survey in Japan. / Horie, Yukihiro; Kitaichi, Nobuyoshi; Hijioka, Kuniaki; Sonoda, Koh Hei; Saishin, Yoshitsugu; Kezuka, Takeshi; Goto, Hiroshi; Takeuchi, Masaru; Nakamura, Satoshi; Kimoto, Takashi; Shimakawa, Machiko; Kita, Mihori; Sugita, Sunao; Mochizuki, Manabu; Hori, Junko; Iwata, Mitsuhiro; Shoji, Jun; Fukuda, Masahide; Kaburaki, Toshikatsu; Numaga, Jiro; Kawashima, Hidetoshi; Fukushima, Astuki; Joko, Takeshi; Takai, Nanae; Ozawa, Yoko; Meguro, Akira; Mizuki, Nobuhisa; Namba, Kenichi; Ishida, Susumu; Ohno, Shigeaki.

In: Clinical and Experimental Rheumatology, Vol. 34, 2016, p. 111-114.

Research output: Contribution to journalArticle

Horie, Y, Kitaichi, N, Hijioka, K, Sonoda, KH, Saishin, Y, Kezuka, T, Goto, H, Takeuchi, M, Nakamura, S, Kimoto, T, Shimakawa, M, Kita, M, Sugita, S, Mochizuki, M, Hori, J, Iwata, M, Shoji, J, Fukuda, M, Kaburaki, T, Numaga, J, Kawashima, H, Fukushima, A, Joko, T, Takai, N, Ozawa, Y, Meguro, A, Mizuki, N, Namba, K, Ishida, S & Ohno, S 2016, 'Ocular Behçet's disease is less complicated with allergic disorders. A nationwide survey in Japan', Clinical and Experimental Rheumatology, vol. 34, pp. 111-114.
Horie, Yukihiro ; Kitaichi, Nobuyoshi ; Hijioka, Kuniaki ; Sonoda, Koh Hei ; Saishin, Yoshitsugu ; Kezuka, Takeshi ; Goto, Hiroshi ; Takeuchi, Masaru ; Nakamura, Satoshi ; Kimoto, Takashi ; Shimakawa, Machiko ; Kita, Mihori ; Sugita, Sunao ; Mochizuki, Manabu ; Hori, Junko ; Iwata, Mitsuhiro ; Shoji, Jun ; Fukuda, Masahide ; Kaburaki, Toshikatsu ; Numaga, Jiro ; Kawashima, Hidetoshi ; Fukushima, Astuki ; Joko, Takeshi ; Takai, Nanae ; Ozawa, Yoko ; Meguro, Akira ; Mizuki, Nobuhisa ; Namba, Kenichi ; Ishida, Susumu ; Ohno, Shigeaki. / Ocular Behçet's disease is less complicated with allergic disorders. A nationwide survey in Japan. In: Clinical and Experimental Rheumatology. 2016 ; Vol. 34. pp. 111-114.
@article{627a6ee401474524aa7376ca4d4446df,
title = "Ocular Beh{\cc}et's disease is less complicated with allergic disorders. A nationwide survey in Japan",
abstract = "Objective. Beh{\cc}et's disease (BD) is a systemic inflammatory disorder polarised to the Th1 and Th17 immune systems. Allergic diseases are polarised to the Th2 immune system. The aim of the present study is to investigate the prevalence of allergic diseases in patients who have BD. Methods. The study involved a largescale interview survey of Japanese patients with BD at 21 institutes of ophthalmology; 353 patients (255 males and 98 females) were recruited for this study. We analysed the history of allergic diseases such as atopic dermatitis (AD), allergic rhinitis (AR), bronchial asthma (BA) and drug/food allergies (FA). Results. Oral aphthous ulcers, ocular lesions, skin lesions, genital ulcers, arthritis, neurological lesions, intestinal lesions, deep vein thrombosis and epididymitis were reported in 95.8{\%}, 98.6{\%}, 72.5{\%}, 44.8{\%}, 13.9{\%}, 6.8{\%}, 6.2{\%}, 3.7{\%} and 1.4{\%} of the patients, respectively. It was also reported that 73 patients (20.7{\%}) had histories of allergic diseases: AD (5 cases, 1.4{\%}), AR (36 cases, 10.2{\%}), BA (19 cases, 5.4{\%}) and FA (30 cases, 8.5{\%}). This percentage was significantly lower than in a survey that Japan's Ministry of Health, Labour and Welfare conducted for healthy population (47.6{\%}) (odds ratio = 0.29, 95{\%} confidence interval = 0.22-0.38, p=4.9×10-22). Frequencies of posterior/pan-uveitis, relatively severe ocular findings, and visual prognosis were not affected by a history of allergic diseases in BD. Conclusion. Patients with BD had fewer complications from allergic diseases than did the entire population of Japan.",
keywords = "Allergic diseases, Beh{\cc}et's disease, Silk Road disease, Th1, Th2",
author = "Yukihiro Horie and Nobuyoshi Kitaichi and Kuniaki Hijioka and Sonoda, {Koh Hei} and Yoshitsugu Saishin and Takeshi Kezuka and Hiroshi Goto and Masaru Takeuchi and Satoshi Nakamura and Takashi Kimoto and Machiko Shimakawa and Mihori Kita and Sunao Sugita and Manabu Mochizuki and Junko Hori and Mitsuhiro Iwata and Jun Shoji and Masahide Fukuda and Toshikatsu Kaburaki and Jiro Numaga and Hidetoshi Kawashima and Astuki Fukushima and Takeshi Joko and Nanae Takai and Yoko Ozawa and Akira Meguro and Nobuhisa Mizuki and Kenichi Namba and Susumu Ishida and Shigeaki Ohno",
year = "2016",
language = "English",
volume = "34",
pages = "111--114",
journal = "Clinical and Experimental Rheumatology",
issn = "0392-856X",
publisher = "Clinical and Experimental Rheumatology S.A.S.",

}

TY - JOUR

T1 - Ocular Behçet's disease is less complicated with allergic disorders. A nationwide survey in Japan

AU - Horie, Yukihiro

AU - Kitaichi, Nobuyoshi

AU - Hijioka, Kuniaki

AU - Sonoda, Koh Hei

AU - Saishin, Yoshitsugu

AU - Kezuka, Takeshi

AU - Goto, Hiroshi

AU - Takeuchi, Masaru

AU - Nakamura, Satoshi

AU - Kimoto, Takashi

AU - Shimakawa, Machiko

AU - Kita, Mihori

AU - Sugita, Sunao

AU - Mochizuki, Manabu

AU - Hori, Junko

AU - Iwata, Mitsuhiro

AU - Shoji, Jun

AU - Fukuda, Masahide

AU - Kaburaki, Toshikatsu

AU - Numaga, Jiro

AU - Kawashima, Hidetoshi

AU - Fukushima, Astuki

AU - Joko, Takeshi

AU - Takai, Nanae

AU - Ozawa, Yoko

AU - Meguro, Akira

AU - Mizuki, Nobuhisa

AU - Namba, Kenichi

AU - Ishida, Susumu

AU - Ohno, Shigeaki

PY - 2016

Y1 - 2016

N2 - Objective. Behçet's disease (BD) is a systemic inflammatory disorder polarised to the Th1 and Th17 immune systems. Allergic diseases are polarised to the Th2 immune system. The aim of the present study is to investigate the prevalence of allergic diseases in patients who have BD. Methods. The study involved a largescale interview survey of Japanese patients with BD at 21 institutes of ophthalmology; 353 patients (255 males and 98 females) were recruited for this study. We analysed the history of allergic diseases such as atopic dermatitis (AD), allergic rhinitis (AR), bronchial asthma (BA) and drug/food allergies (FA). Results. Oral aphthous ulcers, ocular lesions, skin lesions, genital ulcers, arthritis, neurological lesions, intestinal lesions, deep vein thrombosis and epididymitis were reported in 95.8%, 98.6%, 72.5%, 44.8%, 13.9%, 6.8%, 6.2%, 3.7% and 1.4% of the patients, respectively. It was also reported that 73 patients (20.7%) had histories of allergic diseases: AD (5 cases, 1.4%), AR (36 cases, 10.2%), BA (19 cases, 5.4%) and FA (30 cases, 8.5%). This percentage was significantly lower than in a survey that Japan's Ministry of Health, Labour and Welfare conducted for healthy population (47.6%) (odds ratio = 0.29, 95% confidence interval = 0.22-0.38, p=4.9×10-22). Frequencies of posterior/pan-uveitis, relatively severe ocular findings, and visual prognosis were not affected by a history of allergic diseases in BD. Conclusion. Patients with BD had fewer complications from allergic diseases than did the entire population of Japan.

AB - Objective. Behçet's disease (BD) is a systemic inflammatory disorder polarised to the Th1 and Th17 immune systems. Allergic diseases are polarised to the Th2 immune system. The aim of the present study is to investigate the prevalence of allergic diseases in patients who have BD. Methods. The study involved a largescale interview survey of Japanese patients with BD at 21 institutes of ophthalmology; 353 patients (255 males and 98 females) were recruited for this study. We analysed the history of allergic diseases such as atopic dermatitis (AD), allergic rhinitis (AR), bronchial asthma (BA) and drug/food allergies (FA). Results. Oral aphthous ulcers, ocular lesions, skin lesions, genital ulcers, arthritis, neurological lesions, intestinal lesions, deep vein thrombosis and epididymitis were reported in 95.8%, 98.6%, 72.5%, 44.8%, 13.9%, 6.8%, 6.2%, 3.7% and 1.4% of the patients, respectively. It was also reported that 73 patients (20.7%) had histories of allergic diseases: AD (5 cases, 1.4%), AR (36 cases, 10.2%), BA (19 cases, 5.4%) and FA (30 cases, 8.5%). This percentage was significantly lower than in a survey that Japan's Ministry of Health, Labour and Welfare conducted for healthy population (47.6%) (odds ratio = 0.29, 95% confidence interval = 0.22-0.38, p=4.9×10-22). Frequencies of posterior/pan-uveitis, relatively severe ocular findings, and visual prognosis were not affected by a history of allergic diseases in BD. Conclusion. Patients with BD had fewer complications from allergic diseases than did the entire population of Japan.

KW - Allergic diseases

KW - Behçet's disease

KW - Silk Road disease

KW - Th1

KW - Th2

UR - http://www.scopus.com/inward/record.url?scp=85012860883&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85012860883&partnerID=8YFLogxK

M3 - Article

C2 - 27791954

AN - SCOPUS:85012860883

VL - 34

SP - 111

EP - 114

JO - Clinical and Experimental Rheumatology

JF - Clinical and Experimental Rheumatology

SN - 0392-856X

ER -