Ocular complications in a child with acute graft-versus-host disease following cord blood stem cell transplantation: Therapeutic challenges

Miki Uchino, Yoko Ogawa, Masataka Kawai, Hiroyuki Shimada, Kaori Kameyama, Shinichiro Okamoto, Murat Dogru, Kazuo Tsubota

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

We present the first child case of pseudomembranous conjunctivitis accompanied by an extensive corneal ulcer with acute graft-versus-host disease (GVHD) after cord blood stem cell transplantation (CBSCT). The histopathology of the pseudomembrane and the ocular changes following its excision were investigated specifically. One week after the excision of pseudomembrane, the extensive corneal epithelial defects had totally disappeared. Pseudomembrane excision may be an effective method of treatment in corneal epithelial defects observed after GVHD.

Original languageEnglish
Pages (from-to)545-548
Number of pages4
JournalActa Ophthalmologica Scandinavica
Volume84
Issue number4
DOIs
Publication statusPublished - 2006 Aug

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Cord Blood Stem Cell Transplantation
Graft vs Host Disease
Corneal Ulcer
Conjunctivitis
Therapeutics

Keywords

  • Cord blood stem cell transplantation
  • Corneal ulcer
  • Graft-versus-host disease
  • Pseudomembrane

ASJC Scopus subject areas

  • Ophthalmology

Cite this

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abstract = "We present the first child case of pseudomembranous conjunctivitis accompanied by an extensive corneal ulcer with acute graft-versus-host disease (GVHD) after cord blood stem cell transplantation (CBSCT). The histopathology of the pseudomembrane and the ocular changes following its excision were investigated specifically. One week after the excision of pseudomembrane, the extensive corneal epithelial defects had totally disappeared. Pseudomembrane excision may be an effective method of treatment in corneal epithelial defects observed after GVHD.",
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AU - Uchino, Miki

AU - Ogawa, Yoko

AU - Kawai, Masataka

AU - Shimada, Hiroyuki

AU - Kameyama, Kaori

AU - Okamoto, Shinichiro

AU - Dogru, Murat

AU - Tsubota, Kazuo

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KW - Pseudomembrane

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