Ocular surface changes with applanation contact lens and coupling fluid use after argon laser photocoagulation in noninsulin-dependent diabetes mellitus

Murat Dogru, Berkant Kaderli, Oner Gelisken, Ali Yücel, Remzi Avci, Eiki Goto, Shigeto Shimmura, Jun Shimazaki, Kazuo Tsubota

Research output: Contribution to journalArticle

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Abstract

Purpose To describe the effect of coupling solutions used during laser photocoagulation on the ocular surface of patients with noninsulin-dependent diabetes mellitus (NIDDM). Design A prospective case-controlled study. Methods Ninety-two eyes of 46 NIDDM patients with clinically significant macular edema, poor metabolic control of diabetes, and peripheral neuropathy and 100 eyes of 50 normal control subjects were studied. The patients' eyes were assigned to argon green focal/grid laser photocoagulation using an applanation contact lens and one of the coupling fluids; 2% methocel, Thilo-Tears Gel, 1.4% sodium hyaluronate, or 0.9% simple saline. The control subjects received time-matched three-mirror contact lens fundus examinations. All subjects underwent corneal sensitivity measurements, Schirmer test, tear film breakup time, and corneal fluorescein staining before as well as 3 and 8 days after the laser procedures and contact lens examinations. Patients with corneal problems persisting after 8 days were followed longer. Results Diabetic eyes assigned to 2% methocel and 1.4% sodium hyaluronate had significantly lower mean corneal sensitivities and break-up time values as well as significantly higher mean fluorescein staining scores at all examination points after laser photocoagulation. All diabetic eyes with aqueous deficiency assigned to 2% methocel and 1.4% sodium hyaluronate developed delayed corneal epithelial healing. Conclusion The use of viscous coupling solutions during applanation contact lens-aided laser procedures may be detrimental for the corneal epithelium in poorly controlled NIDDM patients with peripheral neuropathy and coexisting aqueous deficiency.

Original languageEnglish
Pages (from-to)381-388
Number of pages8
JournalAmerican Journal of Ophthalmology
Volume138
Issue number3
DOIs
Publication statusPublished - 2004 Sep
Externally publishedYes

Fingerprint

Light Coagulation
Argon
Contact Lenses
Type 2 Diabetes Mellitus
Lasers
Methylcellulose
Hyaluronic Acid
Peripheral Nervous System Diseases
Fluorescein
Tears
Staining and Labeling
Corneal Epithelium
Macular Edema
Gels

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Ocular surface changes with applanation contact lens and coupling fluid use after argon laser photocoagulation in noninsulin-dependent diabetes mellitus. / Dogru, Murat; Kaderli, Berkant; Gelisken, Oner; Yücel, Ali; Avci, Remzi; Goto, Eiki; Shimmura, Shigeto; Shimazaki, Jun; Tsubota, Kazuo.

In: American Journal of Ophthalmology, Vol. 138, No. 3, 09.2004, p. 381-388.

Research output: Contribution to journalArticle

Dogru, Murat ; Kaderli, Berkant ; Gelisken, Oner ; Yücel, Ali ; Avci, Remzi ; Goto, Eiki ; Shimmura, Shigeto ; Shimazaki, Jun ; Tsubota, Kazuo. / Ocular surface changes with applanation contact lens and coupling fluid use after argon laser photocoagulation in noninsulin-dependent diabetes mellitus. In: American Journal of Ophthalmology. 2004 ; Vol. 138, No. 3. pp. 381-388.
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abstract = "Purpose To describe the effect of coupling solutions used during laser photocoagulation on the ocular surface of patients with noninsulin-dependent diabetes mellitus (NIDDM). Design A prospective case-controlled study. Methods Ninety-two eyes of 46 NIDDM patients with clinically significant macular edema, poor metabolic control of diabetes, and peripheral neuropathy and 100 eyes of 50 normal control subjects were studied. The patients' eyes were assigned to argon green focal/grid laser photocoagulation using an applanation contact lens and one of the coupling fluids; 2{\%} methocel, Thilo-Tears Gel, 1.4{\%} sodium hyaluronate, or 0.9{\%} simple saline. The control subjects received time-matched three-mirror contact lens fundus examinations. All subjects underwent corneal sensitivity measurements, Schirmer test, tear film breakup time, and corneal fluorescein staining before as well as 3 and 8 days after the laser procedures and contact lens examinations. Patients with corneal problems persisting after 8 days were followed longer. Results Diabetic eyes assigned to 2{\%} methocel and 1.4{\%} sodium hyaluronate had significantly lower mean corneal sensitivities and break-up time values as well as significantly higher mean fluorescein staining scores at all examination points after laser photocoagulation. All diabetic eyes with aqueous deficiency assigned to 2{\%} methocel and 1.4{\%} sodium hyaluronate developed delayed corneal epithelial healing. Conclusion The use of viscous coupling solutions during applanation contact lens-aided laser procedures may be detrimental for the corneal epithelium in poorly controlled NIDDM patients with peripheral neuropathy and coexisting aqueous deficiency.",
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N2 - Purpose To describe the effect of coupling solutions used during laser photocoagulation on the ocular surface of patients with noninsulin-dependent diabetes mellitus (NIDDM). Design A prospective case-controlled study. Methods Ninety-two eyes of 46 NIDDM patients with clinically significant macular edema, poor metabolic control of diabetes, and peripheral neuropathy and 100 eyes of 50 normal control subjects were studied. The patients' eyes were assigned to argon green focal/grid laser photocoagulation using an applanation contact lens and one of the coupling fluids; 2% methocel, Thilo-Tears Gel, 1.4% sodium hyaluronate, or 0.9% simple saline. The control subjects received time-matched three-mirror contact lens fundus examinations. All subjects underwent corneal sensitivity measurements, Schirmer test, tear film breakup time, and corneal fluorescein staining before as well as 3 and 8 days after the laser procedures and contact lens examinations. Patients with corneal problems persisting after 8 days were followed longer. Results Diabetic eyes assigned to 2% methocel and 1.4% sodium hyaluronate had significantly lower mean corneal sensitivities and break-up time values as well as significantly higher mean fluorescein staining scores at all examination points after laser photocoagulation. All diabetic eyes with aqueous deficiency assigned to 2% methocel and 1.4% sodium hyaluronate developed delayed corneal epithelial healing. Conclusion The use of viscous coupling solutions during applanation contact lens-aided laser procedures may be detrimental for the corneal epithelium in poorly controlled NIDDM patients with peripheral neuropathy and coexisting aqueous deficiency.

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