Ocular surface reconstruction for thermal burns caused by fireworks

Jun Shimazaki, Kenji Konomi, Shigeto Shimmura, Kazuo Tsubota

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Purpose: To describe 6 eyes with severe firework-related ocular surface injuries that were treated by limbal stem cell transplantation combined with amniotic membrane transplantation (AMT). Methods: Six eyes of 6 patients with firework-related ocular injuries were retrospectively studied. All subjects were men, with age ranging from 9 to 26 years. All patients were in chronic stage of thermal injury, and all had total limbal stem cell dysfunction and subsequent conjunctival fibrosis. They had limbal stem cell transplantation (1 had an allograft and 5 had autograft transplantation) combined with AMT to restore vision. Mitomycin C was used in 1 eye intraoperatively. Results: After ocular surface reconstruction using limbal stem cell transplantation combined with AMT, corneal epithelialization was achieved in 4 eyes after a mean duration of 20.8 ± 12.2 days (range, 4-33 days). After a mean follow-up period of 36 months (range, 5-87 months), marked reduction of fibrosis was noted in all eyes. At last examination, the corneal surface was covered by corneal-phenotype epithelium in 4 eyes, and the remaining 2 eyes had conjunctivalization. The cornea was optically clear in 3 eyes, with corrected visual acuity of 20/100 in these 3 eyes. Both eyes that developed conjunctivalization had massive fibrosis preoperatively and severe eyelid deformities. Conclusion: Although severe firework-related ocular surface injuries were difficult to treat, limbal stem cell transplantation combined with AMT enable some success in cosmetic and visual outcome. Management of eyelid abnormalities and ocular surface fibrosis seemed to be a key to success in visual rehabilitation.

Original languageEnglish
Pages (from-to)139-145
Number of pages7
JournalCornea
Volume25
Issue number2
DOIs
Publication statusPublished - 2006 Feb

Fingerprint

Burns
Hot Temperature
Amnion
Stem Cell Transplantation
Eye Injuries
Fibrosis
Transplantation
Eyelids
Corneal Epithelium
Corneal Transplantation
Autografts
Mitomycin
Cosmetics
Cornea
Visual Acuity
Allografts
Stem Cells
Rehabilitation
Phenotype

Keywords

  • Amniotic membrane
  • Cornea
  • Limbal stem cells
  • Thermal burn
  • Transplantation

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Ocular surface reconstruction for thermal burns caused by fireworks. / Shimazaki, Jun; Konomi, Kenji; Shimmura, Shigeto; Tsubota, Kazuo.

In: Cornea, Vol. 25, No. 2, 02.2006, p. 139-145.

Research output: Contribution to journalArticle

Shimazaki, Jun ; Konomi, Kenji ; Shimmura, Shigeto ; Tsubota, Kazuo. / Ocular surface reconstruction for thermal burns caused by fireworks. In: Cornea. 2006 ; Vol. 25, No. 2. pp. 139-145.
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