TY - JOUR
T1 - Odobromoamide, a terminal alkynyl bromide-containing cyclodepsipeptide from the marine cyanobacterium okeania sp.
AU - Sueyoshi, Kosuke
AU - Kudo, Takafumi
AU - Yamano, Aki
AU - Sumimoto, Shimpei
AU - Iwasaki, Arihiro
AU - Suenaga, Kiyotake
AU - Teruya, Toshiaki
N1 - Publisher Copyright:
© 2017 The Chemical Society of Japan.
PY - 2017
Y1 - 2017
N2 - The bioassay-guided fractionation of the Okinawan marine cyanobacterium Okeania sp. led to the isolation of the novel cyclodepsipeptide odobromoamide (1). The gross structure of 1 was determined by spectroscopic analyses, and its absolute stereochemistry was determined using a variety of different methods, including chemical derivatization and degradation followed by HPLC analysis. In addition, odobromoamide (1) exhibited broad-spectrum cytotoxicity against a human cancer cell line panel.
AB - The bioassay-guided fractionation of the Okinawan marine cyanobacterium Okeania sp. led to the isolation of the novel cyclodepsipeptide odobromoamide (1). The gross structure of 1 was determined by spectroscopic analyses, and its absolute stereochemistry was determined using a variety of different methods, including chemical derivatization and degradation followed by HPLC analysis. In addition, odobromoamide (1) exhibited broad-spectrum cytotoxicity against a human cancer cell line panel.
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U2 - 10.1246/bcsj.20160417
DO - 10.1246/bcsj.20160417
M3 - Article
AN - SCOPUS:85020377306
SN - 0009-2673
VL - 90
SP - 436
EP - 440
JO - Bulletin of the Chemical Society of Japan
JF - Bulletin of the Chemical Society of Japan
IS - 4
ER -
