Olfactory cells via nasal biopsy reflect the developing brain in gene expression profiles: Utility and limitation of the surrogate tissues in research for brain disorders

Yasue Horiuchi, Shin ichi Kano, Koko Ishizuka, Nicola G. Cascella, Seiji Ishii, C. Conover Talbot, Andrew E. Jaffe, Hideyuki Okano, Jonathan Pevsner, Carlo Colantuoni, Akira Sawa

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

Human olfactory cells obtained by rapid nasal biopsy have been suggested to be a good surrogate system to address brain disease-associated molecular changes. Nonetheless, whether use of this experimental strategy is justified remains unclear. Here we compared expression profiles of olfactory cells systematically with those from the brain tissues and other cells. Principal component analysis indicated that the expression profiles of olfactory cells are very different from those of blood cells, but are closer to those of stem cells, in particular mesenchymal stem cells, that can be differentiated into the cells of the central nervous system.

Original languageEnglish
Pages (from-to)247-250
Number of pages4
JournalNeuroscience Research
Volume77
Issue number4
DOIs
Publication statusPublished - 2013 Dec

Fingerprint

Brain Diseases
Transcriptome
Nose
Biopsy
Brain
Research
Principal Component Analysis
Mesenchymal Stromal Cells
Blood Cells
Stem Cells
Central Nervous System

Keywords

  • Bipolar disorder
  • Gene expression profile
  • Lymphoblasts
  • Olfactory cells
  • Schizophrenia
  • Stem cells

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Olfactory cells via nasal biopsy reflect the developing brain in gene expression profiles : Utility and limitation of the surrogate tissues in research for brain disorders. / Horiuchi, Yasue; Kano, Shin ichi; Ishizuka, Koko; Cascella, Nicola G.; Ishii, Seiji; Talbot, C. Conover; Jaffe, Andrew E.; Okano, Hideyuki; Pevsner, Jonathan; Colantuoni, Carlo; Sawa, Akira.

In: Neuroscience Research, Vol. 77, No. 4, 12.2013, p. 247-250.

Research output: Contribution to journalArticle

Horiuchi, Yasue ; Kano, Shin ichi ; Ishizuka, Koko ; Cascella, Nicola G. ; Ishii, Seiji ; Talbot, C. Conover ; Jaffe, Andrew E. ; Okano, Hideyuki ; Pevsner, Jonathan ; Colantuoni, Carlo ; Sawa, Akira. / Olfactory cells via nasal biopsy reflect the developing brain in gene expression profiles : Utility and limitation of the surrogate tissues in research for brain disorders. In: Neuroscience Research. 2013 ; Vol. 77, No. 4. pp. 247-250.
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