Olfactory neuroblastoma. A clinical analysis of 31 cases

Mariko Sekimizu, Wataru Shimbashi, Kazuyoshi Kawabata, Hiroki Mitani, Hiroyuki Yonekawa, Hirofumi Fukushima, Tohru Sasaki, Akira Seto, Mutsukazu Kitano, Yu Koizumi, Ryosuke Kamiyama, Aya Ebina, Mitsutaka Adachi, Yukiko Sato, Shunji Takahashi

Research output: Contribution to journalArticle

Abstract

Olfactory neuroblastoma (ONB) is a rare nasal malignancy. Because of its rarity, established treatments are lacking. The present retrospective study investigated the efficacy of CADO-CVP against ONB in 31 patients initially treated in the Department of Head and Neck at the Cancer Institute Hospital between 1992 and 2012. We have previously administered CADO-CVP as induction chemotherapy, achieving a high response rate. Fiveyear overall and disease-free survival rates were 82% and 53%, respectively. Disease-free survival rates differed significantly between the groups with and without induction chemotherapy. Four patients showed recurrence at over 5 years after initial treatment. We therefore consider that long-term follow-up is important for patients with ONB.

Original languageEnglish
Pages (from-to)8-12
Number of pages5
JournalJapanese Journal of Head and Neck Cancer
Volume43
Issue number1
DOIs
Publication statusPublished - 2017
Externally publishedYes

Keywords

  • CADO-CVP
  • Induction chemotherapy
  • Olfactory neuroblastoma

ASJC Scopus subject areas

  • Otorhinolaryngology
  • Oncology

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  • Cite this

    Sekimizu, M., Shimbashi, W., Kawabata, K., Mitani, H., Yonekawa, H., Fukushima, H., Sasaki, T., Seto, A., Kitano, M., Koizumi, Y., Kamiyama, R., Ebina, A., Adachi, M., Sato, Y., & Takahashi, S. (2017). Olfactory neuroblastoma. A clinical analysis of 31 cases. Japanese Journal of Head and Neck Cancer, 43(1), 8-12. https://doi.org/10.5981/jjhnc.43.8